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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11440
Species: Mus musculus
RGD Object: Gene
Symbol: Trp53
Name: transformation related protein 53
Acc ID: CHEBI:67272
Term: perifosine
Definition: A phospholipid consisting of 1,1-dimethylpiperidinium-4-yl hydrogen phosphate in which the hydrogen is replaced by a stearyl (octadecyl) group.
Chemical ID: MESH:C105905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDperifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]PMID:30265530
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