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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDglyceryl 2-arachidonate results in decreased expression of TNF mRNAPMID:16364651
Tnfmultiple interactionsEXP 6480464CTDglyceryl 2-arachidonate inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]; glyceryl 2-arachidonate inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of TNF protein]PMID:30611738 PMID:30769029
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDglyceryl 2-arachidonate inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]PMID:12509806
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