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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11415
Species: Mus musculus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thradecreases expressionEXP 6480464CTDEstradiol results in decreased expression of THRA mRNAPMID:25575267
Thradecreases expressionISOThra (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of THRA mRNAPMID:7684602
Thraincreases expressionISOTHRA (Homo sapiens)6480464CTDEstradiol results in increased expression of THRA mRNAPMID:19027819 PMID:32030086
Thramultiple interactionsISOThra (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of THRA mRNA; Estradiol promotes the reaction [bisphenol A results in decreased expression of THRA mRNA]; Estradiol promotes the reaction [bisphenol AF results in decreased expression of THRA mRNA]PMID:27993100 PMID:30099086
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