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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11379
Species: Mus musculus
RGD Object: Gene
Symbol: Tac1
Name: tachykinin 1
Acc ID: CHEBI:70773
Term: capsazepine
Definition: A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist.
Chemical ID: MESH:C071423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tac1multiple interactionsEXP 6480464CTDcapsazepine inhibits the reaction [[Ovalbumin co-treated with Formaldehyde] results in increased expression of TAC1 protein]; capsazepine inhibits the reaction [Acids results in increased secretion of TAC1 protein]PMID:16091555 PMID:23671638
Tac1multiple interactionsISOTac1 (Rattus norvegicus)6480464CTDcapsazepine inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]; capsazepine inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; capsazepine inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein]PMID:15750287 PMID:18809416 PMID:22198006 PMID:30583000
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