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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11379
Species: Mus musculus
RGD Object: Gene
Symbol: Tac1
Name: tachykinin 1
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tac1decreases expressionISOTac1 (Rattus norvegicus)6480464CTDnimesulide results in decreased expression of TAC1 mRNAPMID:21811393
Tac1multiple interactionsISOTac1 (Rattus norvegicus)6480464CTDnimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [NGF protein results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [NGF results in increased expression of TAC1 mRNA]PMID:21811393
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