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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11379
Species: Mus musculus
RGD Object: Gene
Symbol: Tac1
Name: tachykinin 1
Acc ID: CHEBI:32588
Term: potassium chloride
Definition: A metal chloride salt with a K(+) counterion.
Chemical ID: MESH:D011189
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tac1increases expressionEXP 6480464CTDPotassium Chloride results in increased expression of TAC1 mRNAPMID:21294877
Tac1increases secretionEXP 6480464CTDPotassium Chloride results in increased secretion of TAC1 protein alternative formPMID:18845912
Tac1multiple interactionsEXP 6480464CTDSCN10A protein affects the reaction [Potassium Chloride results in increased secretion of TAC1 protein alternative form]PMID:18845912
Tac1increases secretionISOTac1 (Rattus norvegicus)6480464CTDPotassium Chloride results in increased secretion of TAC1 proteinPMID:16039053 PMID:16696851
Tac1multiple interactionsISOTac1 (Rattus norvegicus)6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; 2-aminoethyl diphenylborinate inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]; 2-aminoethyl diphenylborinate promotes the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA; [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; Iloprost promotes the reaction [Potassium Chloride results in increased secretion of TAC1 protein]; KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]PMID:16039053 PMID:16696851 PMID:21811393
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