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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11379
Species: Mus musculus
RGD Object: Gene
Symbol: Tac1
Name: tachykinin 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tac1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of TAC1 mRNA; Lipopolysaccharides results in increased expression of TAC1 proteinPMID:17291600 PMID:21294877
Tac1increases response to substanceEXP 6480464CTDTAC1 results in increased susceptibility to LipopolysaccharidesPMID:21294877
Tac1multiple interactionsEXP 6480464CTDresiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 protein]PMID:17291600
Tac1increases expressionISOTac1 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of TAC1 mRNA; Lipopolysaccharides results in increased expression of TAC1 proteinPMID:12738685 PMID:21570423
Tac1multiple interactionsISOTac1 (Rattus norvegicus)6480464CTD1,3-dimethylthiourea inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 mRNA]PMID:12738685
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