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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11340
Species: Mus musculus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:60579
Term: calcium oxalate
Definition: The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).
Chemical ID: MESH:D002129
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1decreases expressionISOSpp1 (Rattus norvegicus)6480464CTDCalcium Oxalate results in decreased expression of SPP1 proteinPMID:37454925
Spp1multiple interactionsISOSpp1 (Rattus norvegicus)6480464CTD2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]PMID:37414240 PMID:37454925
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