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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11280
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl12decreases expressionEXP 6480464CTDNickel results in decreased expression of CXCL12 mRNAPMID:12540486
Cxcl12multiple interactionsEXP 6480464CTD[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA]PMID:23503329
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