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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11215
Species: Mus musculus
RGD Object: Gene
Symbol: Raf1
Name: v-raf-leukemia viral oncogene 1
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1increases phosphorylationISORaf1 (Rattus norvegicus)6480464CTDzinc chloride results in increased phosphorylation of RAF1 proteinPMID:21575692
Raf1multiple interactionsISORaf1 (Rattus norvegicus)6480464CTD1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]PMID:21575692
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