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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10865
Species: Mus musculus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepraffects response to substanceEXP 6480464CTDLEPR protein affects the susceptibility to IsoproterenolPMID:36776448
Leprincreases expressionISOLepr (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of LEPR mRNA; Isoproterenol results in increased expression of LEPR proteinPMID:20307649
Leprmultiple interactionsISOLepr (Rattus norvegicus)6480464CTDCPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR protein]PMID:20307649
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