Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10811
Species: Mus musculus
RGD Object: Gene
Symbol: Ins1
Name: insulin I
Acc ID: CHEBI:28073
Term: chromium atom
Definition: A chromium group element atom that has atomic number 24.
Chemical ID: MESH:D002857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins1decreases expressionEXP 6480464CTDChromium results in decreased expression of INS1 proteinPMID:16933788
Ins1multiple interactionsEXP 6480464CTD[Chromium co-treated with Vanadates] promotes the reaction [INS1 protein results in increased uptake of Glucose]; [Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of INS1 protein; [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA; [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein; Chromium promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]; Chromium promotes the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]; Chromium promotes the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]; Chromium promotes the reaction [INS1 protein results in increased uptake of Glucose]PMID:15516700 PMID:16842748 PMID:16933788 PMID:20108212
Ins1increases secretionISOIns1 (Rattus norvegicus)6480464CTDChromium deficiency results in increased secretion of INS1 proteinPMID:7476291
Ins1multiple interactionsISOIns1 (Rattus norvegicus)6480464CTDChromium affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; Chromium promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; INS1 protein affects the reaction [Chromium affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; INS1 protein promotes the reaction [TF protein results in increased transport of Chromium]PMID:11472024 PMID:16424121 PMID:9446840
Go Back to source page   Continue to Ontology report