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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10799
Species: Mus musculus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:6076
Term: itraconazole
Definition: An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
Chemical ID: MESH:D017964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5decreases expressionISOIL5 (Homo sapiens)6480464CTDItraconazole results in decreased expression of IL5 mRNAPMID:11886533 PMID:15284827
Il5decreases secretionISOIL5 (Homo sapiens)6480464CTDItraconazole results in decreased secretion of IL5 proteinPMID:11886533 PMID:15284827
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]PMID:11886533
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