Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDnickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B proteinPMID:11751209 PMID:16166746 PMID:25957741
Il1bmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]PMID:25957741
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in decreased expression of IL1B mRNAPMID:29594315
Il1bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDnickel sulfate results in increased expression of IL1B mRNAPMID:11114790
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B proteinPMID:16314067 PMID:16780908 PMID:19702435 PMID:20713136 PMID:21697260 PMID:25673294 PMID:30842373
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in increased secretion of IL1B proteinPMID:11033066 PMID:14650623
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL1B protein; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IL1B protein]PMID:14650623 PMID:24964617
Go Back to source page   Continue to Ontology report