GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases cleavage | EXP | | 6480464 | CTD | Dextran Sulfate results in increased cleavage of IL1B protein | PMID:37001609 | Il1b | increases expression | EXP | | 6480464 | CTD | Dextran Sulfate results in increased expression of IL1B mRNA; Dextran Sulfate results in increased expression of IL1B protein | PMID:15652231 PMID:16774945 PMID:19285099 PMID:19645018 PMID:19940103 PMID:20079348 PMID:20132809 PMID:20423518 PMID:20824662 PMID:21724996 PMID:23568217 PMID:23894361 PMID:24038091 PMID:24384223 PMID:24548422 PMID:25231984 PMID:25448682 PMID:25472953 PMID:25837923 PMID:26190278 PMID:26631293 PMID:26973525 PMID:27125760 PMID:27920257 PMID:27995407 PMID:28421826 PMID:29672155 PMID:30611738 PMID:31715269 PMID:31737179 PMID:31926917 PMID:32033881 PMID:32272095 PMID:33130971 PMID:34964214 PMID:34998820 PMID:35670535 PMID:36135333 PMID:36281492 PMID:37209277 PMID:37263316 PMID:37263555 PMID:38437956 PMID:38583725 PMID:38648921 | Il1b | increases secretion | EXP | | 6480464 | CTD | Dextran Sulfate results in increased secretion of IL1B protein | PMID:30270565 PMID:30972795 PMID:36543318 PMID:37001609 | Il1b | multiple interactions | EXP | | 6480464 | CTD | 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; 3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein]; 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; 7-hydroxyl-1-methylindole-3-acetonitrile inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein; [Dextran Sulfate co-treated with Azoxymethane] results in increased expression of IL1B protein; [Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of IL1B protein; [HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein; [IL17A protein affects the susceptibility to Dextran Sulfate] which affects the expression of IL1B protein; [Streptozocin co-treated with Dextran Sulfate] results in increased expression of IL1B protein; [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IL1B mRNA; [TNFRSF8 protein affects the susceptibility to Dextran Sulfate] which affects the expression of IL1B protein; [TNFSF8 protein affects the susceptibility to Dextran Sulfate] which affects the expression of IL1B protein; ADAM17 protein affects the reaction [Dextran Sulfate results in increased expression of IL1B protein]; AHR gene mutant form promotes the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; apigenin-6,8-di-C-glycopyranoside inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; ATG5 protein affects the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]]; BCL6 protein inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein]; Benzo(a)pyrene inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; CEP 33779 inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of IL1B protein]; CNR2 protein affects the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein]; CNR2 protein affects the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Dexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein]; dorsomorphin inhibits the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]]; Erianin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; fraxinellone inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; gingerenone A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GW 506033X inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; HU 211 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein]; HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; IRF4 protein inhibits the reaction [BCL6 protein inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein]]; IRF4 protein promotes the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; ligustilide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; ligustilide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased cleavage of IL1B protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; phenethyl isothiocyanate inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Quercetin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; thiamet G promotes the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; TLR4 protein affects the reaction [HU 211 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein] | PMID:15652231 PMID:19285099 PMID:19940103 PMID:20132809 PMID:20423518 PMID:21068411 PMID:21724996 PMID:22334590 PMID:23568217 PMID:24038091 PMID:24384223 PMID:24548422 PMID:25231984 PMID:25448682 PMID:25472953 PMID:26190278 PMID:26631293 PMID:26973525 PMID:27125760 PMID:27611972 PMID:27920257 PMID:27995407 PMID:28421826 PMID:29496522 PMID:29672155 PMID:29950665 PMID:30270565 PMID:30611738 PMID:30972795 PMID:31715269 PMID:31737179 PMID:31926917 PMID:32033881 PMID:32272095 PMID:33130971 PMID:34273909 PMID:34964214 PMID:34998820 PMID:36135333 PMID:36265525 PMID:36519841 PMID:36543318 PMID:37001609 PMID:37209277 PMID:37263555 PMID:38164749 PMID:38437956 PMID:38583725 PMID:38648921 | Il1b | increases expression | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | Dextran Sulfate results in increased expression of IL1B mRNA; Dextran Sulfate results in increased expression of IL1B protein | PMID:20881082 PMID:21893696 PMID:25777935 PMID:28438436 PMID:32470352 PMID:36806191 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Dextran Sulfate results in increased expression of IL1B mRNA | PMID:38423481 | Il1b | multiple interactions | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein; banxia xiexin decoction inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; kappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; palmatine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] | PMID:19028472 PMID:20881082 PMID:32470352 PMID:36806191 | | ||||||||||||||||||||||
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