GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il10 | decreases expression | EXP | | 6480464 | CTD | Dextran Sulfate results in decreased expression of IL10 mRNA; Dextran Sulfate results in decreased expression of IL10 protein | PMID:20132809 PMID:21724996 PMID:24384223 PMID:25231984 PMID:26074695 PMID:31926917 PMID:33974900 PMID:38583725 PMID:38648921 | Il10 | increases expression | EXP | | 6480464 | CTD | Dextran Sulfate results in increased expression of IL10 mRNA; Dextran Sulfate results in increased expression of IL10 protein | PMID:21359540 PMID:26973525 PMID:29672155 PMID:31442584 PMID:31807802 PMID:37263316 PMID:38437956 | Il10 | multiple interactions | EXP | | 6480464 | CTD | 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester promotes the reaction [Dextran Sulfate results in increased expression of IL10 protein]; [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein; [TNFRSF8 protein affects the susceptibility to Dextran Sulfate] which affects the secretion of IL10 protein; [TNFSF8 protein affects the susceptibility to Dextran Sulfate] which affects the secretion of IL10 protein; asperuloside inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; BCL6 protein inhibits the reaction [Dextran Sulfate results in decreased expression of and results in decreased secretion of IL10 protein]; biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; celastrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; Chlorpyrifos inhibits the reaction [Dextran Sulfate results in increased expression of IL10 mRNA]; Cholecalciferol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; Coumarins inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; Dextran Sulfate results in decreased expression of and results in decreased secretion of IL10 protein; flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 mRNA]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL10 protein]; huanglian-jie-du decoction inhibits the reaction [Dextran Sulfate results in increased expression of IL10 mRNA]; IRF4 protein inhibits the reaction [BCL6 protein inhibits the reaction [Dextran Sulfate results in decreased expression of and results in decreased secretion of IL10 protein]]; IRF4 protein promotes the reaction [Dextran Sulfate results in decreased expression of and results in decreased secretion of IL10 protein]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein]; Lipopolysaccharides affects the reaction [Dextran Sulfate results in increased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; Resveratrol promotes the reaction [Dextran Sulfate results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]; thiamet G promotes the reaction [Dextran Sulfate results in increased expression of IL10 mRNA] | PMID:20132809 PMID:21068411 PMID:21359540 PMID:24384223 PMID:25026504 PMID:25231984 PMID:26074695 PMID:26973525 PMID:29672155 PMID:31807802 PMID:31926917 PMID:33974900 PMID:37263316 PMID:38164749 PMID:38437956 PMID:38583725 PMID:38648921 | Il10 | increases expression | ISO | Il10 (Rattus norvegicus) | 6480464 | CTD | Dextran Sulfate results in increased expression of IL10 mRNA; Dextran Sulfate results in increased expression of IL10 protein | PMID:20881082 PMID:25777935 PMID:28438436 | Il10 | multiple interactions | ISO | Il10 (Rattus norvegicus) | 6480464 | CTD | kappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of IL10 mRNA] | PMID:20881082 | | ||||||||||||||||||||||
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