Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rincreases phosphorylationISOIGF1R (Homo sapiens)6480464CTDfulvestrant results in increased phosphorylation of IGF1R proteinPMID:19815064
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of IGF1R mRNA]PMID:23261820
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of IGF1R gene; AG 1879 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]; Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]; Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]; tyrphostin AG 1024 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]PMID:19815064 PMID:19879930 PMID:23810794 PMID:31601247
Go Back to source page   Continue to Ontology report