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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDochratoxin A results in increased expression of HMOX1 mRNA; ochratoxin A results in increased expression of HMOX1 proteinPMID:30291945
Hmox1multiple interactionsEXP 6480464CTDochratoxin A affects the reaction [NFE2L2 protein affects the expression of HMOX1 mRNA]PMID:28710020
Hmox1affects expressionISOHMOX1 (Homo sapiens)6480464CTDochratoxin A affects the expression of HMOX1 mRNAPMID:30008028
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of HMOX1 mRNA; ochratoxin A results in decreased expression of HMOX1 proteinPMID:17316727 PMID:26260164 PMID:30559759 PMID:32905824
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of HMOX1 mRNA; ochratoxin A results in increased expression of HMOX1 proteinPMID:15994020 PMID:16251485 PMID:19414514 PMID:23358140
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDochratoxin A results in increased expression of HMOX1 mRNA; ochratoxin A results in increased expression of HMOX1 proteinPMID:30291945
Hmox1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [ochratoxin A results in increased expression of HMOX1 mRNA]; ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]PMID:15994020
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDAHR protein affects the reaction [ochratoxin A results in increased expression of HMOX1 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of HMOX1 mRNA]PMID:30291945
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