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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDAtrazine results in increased expression of HMOX1 mRNAPMID:27957240 PMID:30360616 PMID:36216167
Hmox1multiple interactionsEXP 6480464CTDLycopene inhibits the reaction [Atrazine results in increased expression of HMOX1 mRNA]PMID:30360616 PMID:36216167
Hmox1increases activityISOHmox1 (Rattus norvegicus)6480464CTDAtrazine results in increased activity of HMOX1 proteinPMID:24863870
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDAtrazine results in increased expression of HMOX1 mRNAPMID:27102619 PMID:33715114
Hmox1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; lycopene promotes the reaction [Atrazine results in increased expression of HMOX1 mRNA]PMID:24863870 PMID:27102619
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