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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:4998
Term: fenarimol
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union.
Chemical ID: MESH:C033789
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases expressionEXP 6480464CTDfenarimol results in increased expression of ESR2 mRNAPMID:21722721
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDfenarimol results in increased activity of ESR2 proteinPMID:15064155 PMID:26812056
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDfenarimol results in increased expression of ESR2 mRNAPMID:15261991
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDfenarimol binds to and results in increased activity of ESR2 protein; fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]PMID:15261991 PMID:33049310
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