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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:48984
Term: 8-methylquinoline
Definition: A methylquinoline carrying a methyl substituent at position 8.
Chemical ID: MESH:C057609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTD8-methylquinoline results in increased activity of ESR1 proteinPMID:30896932
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD8-methylquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; Hydralazine inhibits the reaction [8-methylquinoline results in increased activity of ESR1 protein]PMID:30896932
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