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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:38957
Term: 4,4'-thiodiphenol
Definition: A phenol that has formula C12H10O2S.
Chemical ID: MESH:C586730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDbis(4-oxyphenyl)sulfide binds to ESR1 proteinPMID:31836225
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDbis(4-oxyphenyl)sulfide results in increased expression of ESR1 proteinPMID:27880919
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]PMID:27880919
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