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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:7772
Term: omeprazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityEXP 6480464CTDOmeprazole results in decreased activity of CYP1B1 proteinPMID:18420780
Cyp1b1affects expressionISOCYP1B1 (Homo sapiens)6480464CTDOmeprazole affects the expression of CYP1B1 mRNAPMID:25826687
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDOmeprazole results in increased expression of CYP1B1 mRNAPMID:12040753 PMID:12623754 PMID:21703235
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTDOmeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]PMID:21703235
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