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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10430
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Acc ID: CHEBI:5778
Term: hydrochlorothiazide
Definition: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:D006852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b2increases expressionISOCyp11b3 (Rattus norvegicus)6480464CTDHydrochlorothiazide results in increased expression of CYP11B2 mRNAPMID:18796534
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