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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrochlorothiazide
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Accession:CHEBI:5778 term browser browse the term
Definition:A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Esidrix (TN);   Formula=C7H8ClN3O4S2;   InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13);   InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl;   hidroclorotiazida;   hydrochlorothiazidum
 xref: CAS:58-93-5 "ChemIDplus";   CAS:58-93-5 "KEGG COMPOUND";   CAS:58-93-5 "NIST Chemistry WebBook";   DrugBank:DB00999;   Drug_Central:1385 "DrugCentral";   HMDB:HMDB0001928;   KEGG:C07041;   KEGG:D00340;   LINCS:LSM-5308
 xref_mesh: MESH:D006852
 xref: PDBeChem:HCZ;   PMID:24055851 "Europe PMC";   PMID:24657333 "Europe PMC";   PMID:24849193 "Europe PMC";   Reaxys:625101 "Reaxys";   Wikipedia:Hydrochlorothiazide


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hydrochlorothiazide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 JBrowse link 14 118,482,692 118,707,856 RGD:6480464
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Acta1 actin, alpha 1, skeletal muscle JBrowse link 8 123,891,758 123,894,775 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 16 23,146,536 23,157,968 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 13 30,336,356 30,382,867 RGD:6480464
G Aqp2 aquaporin 2 JBrowse link 15 99,579,056 99,584,545 RGD:6480464
G Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 JBrowse link 6 83,743,017 83,758,855 RGD:6480464
G Avp arginine vasopressin JBrowse link 2 130,580,620 130,582,588 RGD:6480464
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 73,891,765 73,894,428 RGD:6480464
G Bdkrb1 bradykinin receptor, beta 1 JBrowse link 12 105,604,091 105,605,511 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:6480464
G Cma1 chymase 1, mast cell JBrowse link 14 55,941,451 55,944,675 RGD:6480464
G Cyba cytochrome b-245, alpha polypeptide JBrowse link 8 122,424,771 122,432,940 RGD:6480464
G Cybb cytochrome b-245, beta polypeptide JBrowse link X 9,435,252 9,487,766 RGD:6480464
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 JBrowse link 15 74,834,892 74,841,643 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Flt1 FMS-like tyrosine kinase 1 JBrowse link 5 147,561,604 147,726,438 RGD:6480464
G H2-Eb1 histocompatibility 2, class II antigen E beta JBrowse link 17 34,305,867 34,316,674 RGD:6480464
G H2-Pa histocompatibility 2, P region alpha locus JBrowse link 17 34,084,613 34,085,852 RGD:6480464
G H2-T23 histocompatibility 2, T region locus 23 JBrowse link 17 36,029,977 36,032,701 RGD:6480464
G Klk1 kallikrein 1 JBrowse link 7 44,225,360 44,229,622 RGD:6480464
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:6480464
G Mr1 major histocompatibility complex, class I-related JBrowse link 1 155,127,874 155,146,814 RGD:6480464
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta JBrowse link 14 54,970,684 54,994,626 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Nox1 NADPH oxidase 1 JBrowse link X 134,086,421 134,137,711 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 7 87,244,430 87,398,710 RGD:6480464
G Nppb natriuretic peptide type B JBrowse link 4 147,985,786 147,987,205 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 8 76,898,083 77,245,012 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Ramp2 receptor (calcitonin) activity modifying protein 2 JBrowse link 11 101,246,334 101,248,250 RGD:6480464
G Ramp3 receptor (calcitonin) activity modifying protein 3 JBrowse link 11 6,658,506 6,677,478 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 JBrowse link 19 8,617,996 8,628,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20752
    role 20730
      biological role 20729
        xenobiotic 18727
          hydrochlorothiazide 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 20752
    subatomic particle 20745
      composite particle 20745
        hadron 20745
          baryon 20745
            nucleon 20745
              atomic nucleus 20745
                atom 20745
                  main group element atom 20665
                    p-block element atom 20665
                      chalcogen 19873
                        oxygen atom 19861
                          oxygen molecular entity 19861
                            hydroxides 19606
                              oxoacid 18960
                                chalcogen oxoacid 11731
                                  sulfur oxoacid 11319
                                    sulfonic acid 7350
                                      sulfonic acid derivative 7350
                                        sulfonamide 3157
                                          hydrochlorothiazide 39
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.