GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc2 | affects secretion | ISO | Abcc2 (Rattus norvegicus) | 6480464 | CTD | ABCC2 protein affects the secretion of Rosuvastatin Calcium | PMID:19853032 | Abcc2 | increases expression | ISO | Abcc2 (Rattus norvegicus) | 6480464 | CTD | Rosuvastatin Calcium results in increased expression of ABCC2 protein | PMID:24909372 | Abcc2 | multiple interactions | ISO | Abcc2 (Rattus norvegicus) | 6480464 | CTD | [Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein] | PMID:19853032 PMID:23562342 PMID:24909372 | Abcc2 | multiple interactions | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein] | PMID:23562342 | | ||||||||||||||||||||||
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