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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:7507
Term: neomycin
Definition: A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections.
Chemical ID: MESH:D009355
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects cleavageEXP 6480464CTDNeomycin affects the cleavage of CASP3 proteinPMID:23429292
Casp3increases expressionEXP 6480464CTDNeomycin results in increased expression of CASP3 mRNA; Neomycin results in increased expression of CASP3 protein modified formPMID:29292089
Casp3multiple interactionsEXP 6480464CTDBIX 01294 affects the reaction [Neomycin affects the cleavage of CASP3 protein]; peoniflorin inhibits the reaction [Neomycin results in increased expression of CASP3 mRNA]; peoniflorin inhibits the reaction [Neomycin results in increased expression of CASP3 protein modified form]PMID:23429292 PMID:29292089
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