GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alad | affects abundance | ISO | ALAD (Homo sapiens) | 6480464 | CTD | ALAD gene SNP affects the abundance of Lead | PMID:16341691 PMID:30025905 | Alad | affects response to substance | ISO | ALAD (Homo sapiens) | 6480464 | CTD | ALAD gene polymorphism affects the susceptibility to Lead; ALAD gene SNP affects the susceptibility to Lead; ALAD polymorphism affects the susceptibility to Lead; ALAD protein affects the susceptibility to Lead | PMID:11049814 PMID:16487505 PMID:17823382 PMID:20123609 PMID:21439310 PMID:21799727 PMID:22101007 PMID:23792432 PMID:24500903 PMID:25963508 PMID:30025905 | Alad | decreases activity | ISO | Alad (Rattus norvegicus) | 6480464 | CTD | Lead results in decreased activity of ALAD protein | PMID:21034764 PMID:21402136 PMID:2748540 | Alad | decreases activity | ISO | ALAD (Homo sapiens) | 6480464 | CTD | Lead results in decreased activity of ALAD protein | PMID:16140629 PMID:17366816 PMID:21241821 PMID:21910133 PMID:30025905 | Alad | decreases expression | ISO | Alad (Rattus norvegicus) | 6480464 | CTD | Lead results in decreased expression of ALAD protein | PMID:15452883 | Alad | decreases expression | ISO | ALAD (Homo sapiens) | 6480464 | CTD | Lead results in decreased expression of ALAD mRNA; Lead results in decreased expression of ALAD protein | PMID:19921347 PMID:19938001 PMID:21396434 | Alad | increases methylation | ISO | ALAD (Homo sapiens) | 6480464 | CTD | Lead results in increased methylation of ALAD promoter | PMID:21396434 | Alad | increases response to substance | ISO | ALAD (Homo sapiens) | 6480464 | CTD | ALAD gene polymorphism results in increased susceptibility to Lead; ALAD gene SNP results in increased susceptibility to Lead; ALAD protein results in increased susceptibility to Lead | PMID:16341691 PMID:21439310 PMID:22101007 | Alad | multiple interactions | ISO | Alad (Rattus norvegicus) | 6480464 | CTD | [Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein; [Arsenic co-treated with Lead] results in decreased activity of ALAD protein; [Disulfiram co-treated with Lead] results in decreased activity of ALAD protein; [Lead co-treated with Cadmium] results in decreased activity of ALAD protein; Gallic Acid inhibits the reaction [Lead results in decreased activity of ALAD protein] | PMID:21034764 PMID:21402136 PMID:22354675 PMID:2748540 | Alad | multiple interactions | ISO | ALAD (Homo sapiens) | 6480464 | CTD | [ALAD gene SNP affects the susceptibility to [Opium co-treated with Lead]] which affects the abundance of Lead; [VDR gene polymorphism co-treated with ALAD gene polymorphism] affects the abundance of Lead; [Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; ALAD gene polymorphism affects the abundance of and affects the susceptibility to Lead; ALAD gene polymorphism affects the susceptibility to and affects the abundance of Lead; ALAD gene SNP affects the susceptibility to [Opium co-treated with Lead]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] | PMID:16263504 PMID:17366816 PMID:19515364 PMID:20510440 PMID:21910133 PMID:30081045 | | ||||||||||||||||||||||
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