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GENE - TERM ANNOTATION REPORT

2 Annotations Found.

An association has been curated linking Kcnj11 and altered insulin secretion pathway in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
  • The annotation has been inferred from sequence orthology with KCNJ11 (Homo sapiens) [(IMP) inferred from mutant phenotype]
  • 17 additional annotations were made from Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
  • 2 RGD objects have been annotated to altered insulin secretion pathway  (PW:0000677)
  • 73 papers in RGD have been used to annotate Kcnj11
  • Curation Notes: DNA:missense mutation::p.E23K (human)


    • An association has been curated linking Kcnj11 and altered insulin secretion pathway in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
  • The annotation has been inferred from sequence orthology with KCNJ11 (Homo sapiens) [(TAS) traceable author statement]
  • 8 additional annotations were made from Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
  • 2 RGD objects have been annotated to altered insulin secretion pathway  (PW:0000677)
  • 73 papers in RGD have been used to annotate Kcnj11
  • Curation Notes: polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population


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