| WKY |
blood glucose level |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
blood glucose amount |
male |
days
| 16 |
317.0 |
mg/dl |
19.0 |
76.0 |
machine read blood glucose test strip |
0.0 |
unx |
168 |
days |
|
99974 |
2378 |
| WKY |
glomerular filtration rate to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 16 |
0.67 |
ml/min/100g |
0.02 |
0.08 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99984 |
2378 |
| WKY |
renal plasma flow to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney plasma flow trait |
male |
days
| 16 |
3.19 |
ml/min/100g |
0.13 |
0.52 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99994 |
2378 |
| WKY |
renal plasma flow to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney plasma flow trait |
male |
days
| 6 |
2.42 |
ml/min/100g |
0.09 |
0.22 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99954 |
2378 |
| WKY |
timed urine volume |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
urine output |
male |
days
| 8 |
38.02 |
ml/d |
5.33 |
15.07 |
metabolic cage urine volume measurement method |
0.0 |
unx |
28 |
days |
|
99967 |
2378 |
| WKY |
kidney glomerular surface area |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney glomerulus size trait |
male |
days
| 16 |
16.4 |
x 10E3 um2 |
4.1 |
16.4 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
150 |
days |
kidney glomerulus surface area (CMO:0003488) |
107464 |
2378 |
| WKY |
renal filtration fraction |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 16 |
0.21 |
null |
0.01 |
0.03 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99989 |
2378 |
| WKY |
renal plasma flow to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney plasma flow trait |
male |
days
| 17 |
3.3 |
ml/min/100g |
0.11 |
0.45 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99992 |
2378 |
| WKY |
timed urine volume |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
urine output |
male |
days
| 16 |
49.25 |
ml/d |
5.18 |
20.74 |
metabolic cage urine volume measurement method |
0.0 |
unx |
168 |
days |
|
100004 |
2378 |
| WKY |
blood glucose level |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
blood glucose amount |
male |
days
| 6 |
367.0 |
mg/dl |
12.0 |
29.39 |
machine read blood glucose test strip |
0.0 |
unx |
28 |
days |
|
99944 |
2378 |
| WKY |
glomerular filtration rate to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 8 |
0.52 |
ml/min/100g |
0.03 |
0.07 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99947 |
2378 |
| WKY |
glomerular filtration rate to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 6 |
0.5 |
ml/min/100g |
0.02 |
0.06 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99949 |
2378 |
| WKY |
renal vascular resistance |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
arterial blood pressure trait |
male |
days
| 8 |
8.8 |
mmHg/ml/min |
0.5 |
1.41 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99962 |
2378 |
| WKY |
renal vascular resistance |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
arterial blood pressure trait |
male |
days
| 6 |
8.8 |
mmHg/ml/min |
0.5 |
1.22 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99964 |
2378 |
| WKY |
timed urine volume |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
urine output |
male |
days
| 6 |
44.93 |
ml/d |
8.78 |
21.52 |
metabolic cage urine volume measurement method |
0.0 |
unx |
28 |
days |
|
99969 |
2378 |
| WKY |
body weight |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
body mass |
male |
days
| 17 |
274.0 |
g |
6.0 |
24.74 |
body weighing method |
0.0 |
unx |
150 |
days |
|
107447 |
2378 |
| WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
days
| 16 |
8.3 |
mg/g |
0.2 |
0.8 |
post excision weight measurement |
0.0 |
unx |
150 |
days |
|
107459 |
2378 |
| WKY |
hematocrit |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
erythrocyte quantity |
male |
days
| 17 |
45.6 |
% |
0.3 |
1.24 |
hematocrit analysis |
0.0 |
unx |
168 |
days |
|
99977 |
2378 |
| WKY |
timed urine volume |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
urine output |
male |
days
| 17 |
41.47 |
ml/d |
4.46 |
18.41 |
metabolic cage urine volume measurement method |
0.0 |
unx |
168 |
days |
|
100002 |
2378 |
| WKY |
renal filtration fraction |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 6 |
0.21 |
null |
0.01 |
0.03 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99959 |
2378 |
| WKY |
body weight |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
body mass |
male |
days
| 16 |
267.0 |
g |
9.0 |
36.0 |
body weighing method |
0.0 |
unx |
150 |
days |
|
107449 |
2378 |
| WKY |
kidney glomerular tuft surface area |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney glomerulus size trait |
male |
days
| 17 |
11.8 |
x 10E3 um2 |
2.9 |
11.96 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
150 |
days |
kidney glomerulus surface area (CMO:0003488) |
107512 |
2378 |
| WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
days
| 16 |
3.1 |
g/kg |
0.1 |
0.4 |
post excision weight measurement |
0.0 |
unx |
150 |
days |
|
107454 |
2378 |
| WKY |
blood glucose level |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
blood glucose amount |
male |
days
| 17 |
312.0 |
mg/dl |
24.0 |
98.95 |
machine read blood glucose test strip |
0.0 |
unx |
168 |
days |
|
99972 |
2378 |
| WKY |
glomerular filtration rate to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 17 |
0.69 |
ml/min/100g |
0.03 |
0.13 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99982 |
2378 |
| WKY |
hematocrit |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
erythrocyte quantity |
male |
days
| 16 |
44.5 |
% |
0.6 |
2.4 |
hematocrit analysis |
0.0 |
unx |
168 |
days |
|
99979 |
2378 |
| WKY |
renal filtration fraction |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 17 |
0.21 |
null |
0.01 |
0.05 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99987 |
2378 |
| WKY |
renal vascular resistance |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
arterial blood pressure trait |
male |
days
| 16 |
6.8 |
mmHg/ml/min |
0.3 |
1.2 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99999 |
2378 |
| WKY |
renal vascular resistance |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
arterial blood pressure trait |
male |
days
| 17 |
6.6 |
mmHg/ml/min |
0.3 |
1.24 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
168 |
days |
|
99997 |
2378 |
| WKY |
body weight |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
body mass |
male |
days
| 6 |
229.0 |
g |
6.0 |
14.7 |
body weighing method |
0.0 |
unx |
28 |
days |
|
99939 |
2378 |
| WKY |
renal plasma flow to body weight ratio |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney plasma flow trait |
male |
days
| 8 |
2.33 |
ml/min/100g |
0.09 |
0.25 |
p-aminohippurate analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99952 |
2378 |
| WKY |
renal filtration fraction |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
glomerular filtration trait |
male |
days
| 8 |
0.23 |
null |
0.12 |
0.34 |
inulin analysis by liquid phase colorimetry |
0.0 |
unx |
28 |
days |
|
99957 |
2378 |
| WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
days
| 17 |
3.2 |
g/kg |
0.1 |
0.41 |
post excision weight measurement |
0.0 |
unx |
150 |
days |
|
107452 |
2378 |
| WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
days
| 17 |
8.2 |
mg/g |
0.2 |
0.82 |
post excision weight measurement |
0.0 |
unx |
150 |
days |
|
107457 |
2378 |
| WKY |
body weight |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
body mass |
male |
days
| 8 |
236.0 |
g |
7.0 |
19.8 |
body weighing method |
0.0 |
unx |
28 |
days |
|
99937 |
2378 |
| WKY |
blood glucose level |
unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
blood glucose amount |
male |
days
| 8 |
352.0 |
mg/dl |
17.0 |
48.08 |
machine read blood glucose test strip |
0.0 |
unx |
28 |
days |
|
99942 |
2378 |
| WKY |
kidney glomerular tuft surface area |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney glomerulus size trait |
male |
days
| 16 |
11.7 |
x 10E3 um2 |
2.9 |
11.6 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
150 |
days |
|
107514 |
2378 |
| WKY |
kidney glomerular surface area |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney glomerulus size trait |
male |
days
| 17 |
17.0 |
x 10E3 um2 |
4.1 |
16.9 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
150 |
days |
kidney glomerulus surface area (CMO:0003488) |
107462 |
2378 |