Phenominer Database Results (59 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
COP liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male  days 10 83.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70203 1302
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male  days 10 19.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70204 1302
BN ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified  days 1.55 % 0.09 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 84780 1603
BDIX/OrlCrl subsequent liver tumorous lesion volume to precedent liver tumorous lesion volume ratio DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 1516.0 % 377.0 1305.97 magnetic resonance imaging liver 0.0 17-31 days after tumor cell injection 70% hepatectomy group POD 24 111003 3191
BDIX/OrlCrl calculated liver tumorous lesion volume measurement DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (between 17 and 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 2.32 cm3 0.59 2.04 magnetic resonance imaging liver 0.0 31 days 30% hepatectomy group POD24 30% hepatectomy group POD24 110987 3191
BDIX/OrlCrl calculated liver tumorous lesion volume measurement DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 0.7 cm3 0.12 0.42 magnetic resonance imaging liver 0.0 24 days 30% hepatectomy group POD17 30% hepatectomy group POD17 110822 3191
WAG/RijCrl number of medium-sized metastatic liver tumors S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. liver integrity trait male 87.0 days 10 12.8 null 3.7 11.7 ex vivo caliper method 0.0 S4MH injection 21 days metastatic liver tumor count by size 108157 3119
WAG/RijCrl number of large metastatic liver tumors S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. liver integrity trait male 87.0 days 10 9.3 null 2.9 9.17 ex vivo caliper method 0.0 S4MH injection 21 days metastatic liver tumor count by size 108158 3119
WAG/RijCrl metastatic lung tumor number S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. lung integrity trait male 87.0 days 10 99.2 null 0.54 1.71 ex vivo visual assessment 0.0 S4MH injection 21 days 108163 3119
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 9 13.8 % 0.8 2.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days remodeling/total ratio 69145 950
F344/NHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 12 126820.0 null 9698.0 33594.86 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68349 912
F344/NHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 12 84.18 % 3.64 12.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68353 912
BN/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 13.69 % 1.99 8.9 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67758 789
F344/NRrrc liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female  days 3 1424.0 null 242.0 419.16 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68617 950
BN/SsNHsd percentage of study population developing hepatocellular carcinoma during a period of time N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 10 10.0 % necropsy 0.0 N-nitrosodiethylamine 490 days CMO:0001068 96758 912
BN ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified  days 2.08 % 0.18 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 84783 1603
BDIX/OrlCrl increase in liver tumorous lesion volume between two points in time DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 0.52 cm3 0.14 0.48 magnetic resonance imaging liver 0.0 17-24 days after tumor cell injection 70% hepatectomy group POD 17 110990 3191
WAG/RijCrl lung wet weight S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. lung mass male 87.0 days 10 1.5 g 0.05 0.16 post excision weight measurement 0.0 S4MH injection 21 days 108161 3119
BN liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 5 180.0 % 4.0 8.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69144 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 3 19.2 % 2.8 4.85 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69148 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 5 15.1 % 1.1 2.46 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69147 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 3 40.6 % 5.4 9.35 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69149 950
F344/NRrrc benign liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 16 22.3 null 2.0 8.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days 69151 950
BN/SsNHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 7 19.83 % 2.09 5.53 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68354 912
F344/NHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 9 3.5 null 0.23 0.69 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68391 912
F344/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 3.26 cm3 x 10000 0.33 1.48 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67731 789
F344/NRrrc volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female  days 3 8.92 % 2.85 4.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68619 950
BDIX/OrlCrl subsequent liver tumorous lesion volume to precedent liver tumorous lesion volume ratio DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 548.0 % 118.0 408.76 magnetic resonance imaging liver 0.0 17-24 days after tumor cell injection 30% hepatectomy group POD17 110999 3191
BDIX/OrlCrl subsequent liver tumorous lesion volume to precedent liver tumorous lesion volume ratio DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 472.0 % 127.0 439.94 magnetic resonance imaging liver 0.0 17-24 days after tumor cell injection 70% hepatectomy group POD 17 110998 3191
BDIX/OrlCrl subsequent liver tumorous lesion volume to precedent liver tumorous lesion volume ratio DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (for 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 2039.0 % 562.0 1946.83 magnetic resonance imaging liver 0.0 17-31 days after tumor cell injection 30% hepatectomy group POD24 111004 3191
BDIX/OrlCrl calculated liver tumorous lesion volume measurement DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (between 17 and 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 1.78 cm3 0.38 1.32 magnetic resonance imaging liver 0.0 31 days 70% hepatectomy group POD24 70% hepatectomy group POD 24 110986 3191
WAG/RijCrl metastatic liver tumor number S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. liver integrity trait male 87.0 days 10 28.7 null 7.3 23.08 ex vivo caliper method 0.0 S4MH injection 21 days metastatic liver tumor count by size 108159 3119
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 5 1070.0 % 143.0 319.76 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69143 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 5 30.4 % 2.7 6.04 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 105 days remodeling/total ratio 69146 950
F344/NRrrc percentage of study population developing benign liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days benign liver tumor incidence 69150 950
BN/SsNHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 7 0.12 cm3 x 10000 0.03 0.07 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68352 912
BN/SsNHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 10 1.3 null 0.13 0.41 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68389 912
F344/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 7875.0 /cm3 624.0 2790.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight need to update double congenicstrain 67713 789
BN/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 0.09 cm3 x 10000 0.02 0.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67736 789
F344/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 80.11 % 6.33 28.32 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67755 789
BN liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female  days 3 1717.0 null 227.0 393.18 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68618 950
F344/NHsd percentage of study population developing hepatocellular carcinoma during a period of time N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 9 89.0 % necropsy 0.0 N-nitrosodiethylamine 490 days CMO:0001068 96757 912
BDIX/OrlCrl increase in liver tumorous lesion volume between two points in time DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 0.59 cm3 0.12 0.42 magnetic resonance imaging liver 0.0 17-24 days after tumor cell injection 30% hepatectomy group POD17 110991 3191
BDIX/OrlCrl increase in liver tumorous lesion volume between two points in time DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (between 17 and 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 1.67 cm3 0.38 1.32 magnetic resonance imaging liver 0.0 17-31 days after tumor cell injection 70% hepatectomy group POD 24 110994 3191
BDIX/OrlCrl ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 30 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 55.2 % 6.0 20.78 ex vivo light microscopy with immunohistochemistry liver 0.0 37 days 70% hepatectomy group POD30 70% hepatectomy group POD 30 110817 3191
BDIX/OrlCrl ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (for 30 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 54.7 % 4.5 15.59 ex vivo light microscopy with immunohistochemistry liver 0.0 37 days 30% hepatectomy group POD30 30% hepatectomy group POD30 110818 3191
BDIX/OrlCrl liver volume after excision and regeneration DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 10 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver size trait male  days 12 8.7 cm3 0.83 2.88 magnetic resonance imaging liver 0.0 10 days 10 days after tumor cell injection 70% hepatectomy group POD 10 110813 3191
WAG/RijCrl number of small metastatic liver tumors S4MH cells (250 X 10E3) (for 21 days) then partial hepatectomy (for 11 days) Garc?a-Alonso I, et al., J Surg Res. 2008 Aug;148(2):185-90. doi: 10.1016/j.jss.2007.06.026. Epub 2007 Aug 2. liver integrity trait male 87.0 days 10 6.5 null 1.2 3.79 ex vivo caliper method 0.0 S4MH injection 21 days metastatic liver tumor count by size 108156 3119
F344/NRrrc malignant liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 16 2.2 null 0.2 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69153 950
F344/NRrrc percentage of study population developing malignant liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male  days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69152 950
BN/SsNHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 7 155800.0 null 19408.0 51348.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68350 912
F344/NHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified  days 12 2.95 cm3 x 10000 0.35 312.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68351 912
BN/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified  days 20 11142.0 /cm3 930.0 4159.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight update term and unit 67721 789
BN volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female  days 3 1.61 % 0.46 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68620 950
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified  days 5 1.25 % 0.05 0.11 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 84785 1603
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified  days 5 1.51 % 0.07 0.16 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 84787 1603
BDIX/OrlCrl increase in liver tumorous lesion volume between two points in time DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (30 %) (between 17 and 31 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 2.21 cm3 0.58 2.01 magnetic resonance imaging liver 0.0 17-31 days after tumor cell injection 30% hepatectomy group POD24 110995 3191
BDIX/OrlCrl calculated liver tumorous lesion volume measurement DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 17 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver integrity trait male  days 12 0.63 cm3 0.14 0.48 magnetic resonance imaging liver 0.0 24 days 70% hepatectomy group POD17 70% hepatectomy group POD 17 110821 3191
BDIX/OrlCrl post excision/regeneration liver volume to original liver volume ratio DHD/K12/TRb cells (1.5 x 10E6 cells) (for 7 days) and DHD/K12/TRb cells (1 x 10E6 cells) (for 7 days) then partial hepatectomy (70 %) (for 10 days) Schwarz L, etal., HPB (Oxford). 2020 Oct;22(10):1480-1489. doi: 10.1016/j.hpb.2020.02.008. Epub 2020 Mar 7. liver size trait male  days 12 237.0 % 19.6 67.9 magnetic resonance imaging liver 0.0 10 days 10 days after tumor cell injection 70% hepatectomy group POD 10 110815 3191