Phenominer Database Results (385 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 14 serial mean 395.0 beats/min 7.0 26.19 vascular indwelling catheter method left femoral artery 0 65468 151
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -96.57 beats/min 21.74 57.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51715 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -112.51 beats/min 21.22 60.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51716 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -13.09 beats/min 24.31 64.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51729 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 13.05 mmHg 2.64 7.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51874 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 11.63 mEq/d 1.0 3.17 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51893 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 8 32.25 mg/d 4.9 13.87 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52134 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 18 112.49 mmHg 2.77 11.74 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52875 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 7 1.61 ng/ml/h 0.88 2.33 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52919 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 15 0.35 mg/dl 0.02 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52236 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 8 1.01 ng/ml/h 0.15 0.43 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52480 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 8 394.19 beats/min 16.08 45.49 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52525 482
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 2.63 mmHg 2.19 4.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50609 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.7 mmHg 0.63 1.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50610 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 0.28 beats/min 13.27 39.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50624 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -26.25 beats/min 11.9 23.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50623 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 392.72 beats/min 8.3 16.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50890 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 3.95 mmHg 4.82 9.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50936 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 109.15 mmHg 2.9 7.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50950 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 33.35 mmHg 3.43 9.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50973 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -5.24 beats/min 10.35 20.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50989 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 3 1.39 ml/min 0.23 0.41 urine creatinine analysis Moms and pups used in studies were fed Teklad 51063 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 8.96 mmHg 2.29 4.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51110 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.6 mmHg 0.68 1.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51111 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 107.04 mmHg 4.18 12.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51152 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 18.33 mmHg 3.71 10.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51196 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -16.65 beats/min 19.02 57.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51210 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -61.89 beats/min 17.82 47.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51229 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 3 388.81 beats/min 6.13 10.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51255 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 3 0.29 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51321 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -19.96 beats/min 18.9 50.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51360 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 0.75 beats/min 17.84 35.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51377 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 364.17 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51587 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 107.88 mmHg 3.52 7.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51637 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 3 0.28 mg/dl 0.03 0.05 radioimmunoassay Moms and pups used in studies were fed Teklad 51655 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 435.45 beats/min 18.67 37.34 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50331 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -34.84 beats/min 18.09 51.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50362 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 11.73 mmHg 3.99 10.55 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50377 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -3.15 beats/min 20.75 41.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50428 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 20 8.6 mg/d 2.2 9.84 urine total protein analysis 0 66151 151
BN/NHsdMcwi kidney glomerulus diameter controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney glomerulus size trait female 97.0 days-101.0 days 22 95.0 um 1.2 5.63 ex vivo light microscopy 0.0 plasma creatinine analysis 67285 151
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart left ventricle mass female 97.0 days-101.0 days 22 0.45 g 0.01 0.05 post excision weight measurement 0.0 67297 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 21 -1.4 ml/min/g 0.3 1.37 electromagnetic flowmetry 0.0 electromagnetic flowmetry change in renal blood flow rate 67305 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 94.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12009 229
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 109.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12012 229
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 123.13 % 6.51 18.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17921 381
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70.0 days-84.0 days 29 153.38 g 1.84 9.91 whole body digital scale 63651 529
BN/NHsdMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 26 34.88 cm 0.12 0.63 in vivo ruler method 63723 529
BN/NHsdMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70.0 days-84.0 days 45 0.74 g 0.01 0.08 digital scale post excision weight measurement 63476 529
BN/NHsdMcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 45 22.29 cm 0.16 1.11 in vivo ruler method 63568 529
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 -7.96 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 63121 528
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 2.42 g/mg 0.15 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 63192 528
BN/NHsdMcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70.0 days-84.0 days 44 132.8 mg/dl 2.81 18.62 standard blood chemistry panel 62515 527
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 62800 528
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 62798 528
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 8 226.5 g 4.09 11.56 whole body digital scale 62964 528
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.23 E-7mole 0.27 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 63051 528
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 20 239.5 g 5.1 22.9 whole body digital scale Moms and pups used in studies were fed Teklad 55239 522
BN/NHsdMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 27 43.7 % 0.34 1.76 automated blood cell counting method 60692 527
BN/NHsdMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70.0 days-84.0 days 27 53.86 fl 0.3 1.55 automated blood cell counting method 60804 527
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70.0 days-84.0 days 27 1.55 g/dl 0.03 0.14 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 60978 527
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70.0 days-84.0 days 44 1.93 g/dl 0.03 0.17 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 60977 527
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 32.98 g/dl 0.14 0.7 automated blood cell counting method 61204 527
BN/NHsdMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70.0 days-84.0 days 27 7.49 x 1000 cells/ul 0.46 2.37 automated blood cell counting method 61430 527
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 0.19 umol/l 0.05 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54967 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 42.5 % 7.43 18.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55096 522
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70.0 days-84.0 days 44 0.1 mg/dl 0.0 0.02 standard blood chemistry panel 62187 527
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70.0 days-84.0 days 27 24.59 mg/dl 0.82 4.27 standard blood chemistry panel 60210 527
BN/NHsdMcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70.0 days-84.0 days 27 9.97 mg/dl 0.09 0.47 standard blood chemistry panel 60282 527
BN/NHsdMcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70.0 days-84.0 days 44 10.27 mg/dl 0.1 0.66 standard blood chemistry panel 60281 527
BN/NHsdMcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 14.4 g/dl 0.09 0.45 automated blood cell counting method 60364 527
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 132.9 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 69531 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 135.6 mmHg 3.2 14.31 vascular indwelling catheter method left femoral artery 120.0 69539 151
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 22 0.46 mEq/d 0.03 0.13 unspecified method 0.0 urine sodium analysis umol/min 69468 151
BN/NHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 25 56.4 mg/dl 4.95 24.75 urine creatinine analysis 0.0 69475 151
BN/NHsdMcwi urine potassium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 22 93.4 mmol/l 5.7 26.74 unspecified method 0.0 urine potassium analysis 69471 151
BN/NHsdMcwi plasma total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood total protein amount female 89.0 days-92.0 days 13 38.6 mg/ml 2.0 7.21 unspecified method 0.0 69483 151
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 92.0 days-94.0 days 8 0.42 mg/dl 0.11 0.31 plasma creatinine analysis 0.0 urine potassium analysis umol/min 69485 151
BN/NHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92.0 days-94.0 days 13 0.02 x 1000 cells/ul 1306.0 4708.85 isolated cell counting method 0.0 69495 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 20 serial mean 369.9 beats/min 5.1 22.81 vascular indwelling catheter method left femoral artery 10800.0 69519 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 130.0 mmHg 3.5 15.65 vascular indwelling catheter method left femoral artery 0.0 69443 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 89.0 days-92.0 days 25 35.0 ml/d 2.0 10.0 urine volume measurement method 0.0 69451 151
BN/NHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 24 30.2 mg/dl 3.87 18.96 urine creatinine analysis 0.0 69455 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 89.0 days-92.0 days 24 0.96 mEq/d 0.04 0.21 unspecified method 0.0 urine potassium analysis 69461 151
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -63.92 beats/min 13.12 39.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51702 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -74.95 beats/min 19.95 39.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51701 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 2 1.65 ml/min 0.23 0.32 urine creatinine analysis Moms and pups used in studies were fed Dyets 51804 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 3 2.06 ng/ml/h 0.69 1.19 radioimmunoassay Moms and pups used in studies were fed Teklad 51844 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 7.17 beats/min 11.83 33.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51927 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 1.28 ml/min 0.07 0.17 urine creatinine analysis Moms and pups used in studies were fed Teklad 51956 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 7.06 mmHg 2.33 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51970 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 10.81 mEq/d 0.58 1.75 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52022 481
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 10 1.47 mEq/d 0.11 0.36 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52972 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 15 1.13 ml/min 0.14 0.55 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52187 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 8 1.74 ml/min 0.15 0.44 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52186 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 8 0.24 mg/dl 0.03 0.07 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52283 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 11 0.77 mEq/d 0.09 0.29 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52333 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 8 349.72 beats/min 7.76 21.94 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52524 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 10 4.05 mg/d 1.24 3.93 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52625 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 21 15.57 mEq/d 1.26 5.76 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52777 482
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 5.59 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50636 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 2.83 beats/min 19.88 56.24 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50687 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 34.55 beats/min 25.93 51.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50688 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.55 mmHg 3.77 10.66 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50707 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 0.72 mmHg 2.7 7.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50706 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 102.53 mmHg 2.47 6.98 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50746 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 -7.15 mmHg 2.83 6.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50812 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 2.23 mmHg 1.67 4.71 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50937 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 31.33 mmHg 3.72 9.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50972 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -3.93 beats/min 14.49 38.34 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51165 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 2 0.26 mg/dl 0.06 0.08 radioimmunoassay Moms and pups used in studies were fed Dyets 51179 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -79.11 beats/min 25.39 71.8 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51230 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 432.84 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51254 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.23 mEq/d 0.15 0.45 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51276 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 17.74 mmHg 6.47 12.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51346 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 10.88 beats/min 4.58 12.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51378 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 43.38 mmHg 2.58 7.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51432 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 4 16.76 mg/d 2.9 5.8 automated urine analysis Moms and pups used in studies were fed Dyets 51445 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 9 10.75 mg/d 1.32 3.95 automated urine analysis Moms and pups used in studies were fed Dyets 51446 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 10 0.44 mg/d 0.07 0.22 automated urine analysis Moms and pups used in studies were fed Teklad 51477 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 437.8 beats/min 17.4 49.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51588 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -3.51 mmHg 2.57 5.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51601 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 389.05 beats/min 11.35 32.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50330 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 90.0 days-94.0 days 10 1.7 ml/min 0.2 0.63 urine creatinine analysis 0.0 plasma creatinine analysis 67283 151
BN/NHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92.0 days-94.0 days 10 56.0 mg/dl 2.1 6.64 plasma total cholesterol measurement test 0.0 67289 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 19 serial mean 22.0 mmHg 3.0 13.08 vascular indwelling catheter method left femoral artery 0.0 67301 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 20 -1.2 ml/min/g 0.7 3.13 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67309 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96.0 days 21 continuous mean 96.0 mmHg 3.0 13.75 vascular indwelling catheter method femoral artery 10800.0 left femoral artery 13275 229
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-92.0 days 20 serial mean 367.0 beats/min 5.0 22.36 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 13309 151
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70.0 days-84.0 days 45 236.4 g 3.64 24.39 whole body digital scale 63650 529
BN/NHsdMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 45 37.8 cm 0.27 1.82 in vivo ruler method 63722 529
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70.0 days-84.0 days 45 0.51 g 0.01 0.05 digital scale post excision weight measurement 63794 529
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70.0 days-84.0 days 45 0.81 g 0.01 0.09 digital scale post excision weight measurement 63404 529
BN/NHsdMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70.0 days-84.0 days 29 0.52 g 0.01 0.04 digital scale post excision weight measurement 63477 529
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 66.75 % 4.42 12.5 wire myography using a Digi-Med tissue force analysis system with force transducer 62651 528
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 53.2 % 4.62 10.33 wire myography using a Digi-Med tissue force analysis system with force transducer 62653 528
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 -6.71 null 0.05 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 62876 528
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 25 155.9 g 2.1 10.6 whole body digital scale Moms and pups used in studies were fed Teklad 55240 522
BN/NHsdMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70.0 days-84.0 days 43 53.36 fl 0.34 2.21 automated blood cell counting method 60803 527
BN/NHsdMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70.0 days-84.0 days 43 1.78 x 1000 cells/ul 0.14 0.95 automated blood cell counting method 60895 527
BN/NHsdMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70.0 days-84.0 days 27 1.32 x 1000 cells/ul 0.18 0.95 automated blood cell counting method 60896 527
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 33.51 g/dl 0.14 0.89 automated blood cell counting method 61203 527
BN/NHsdMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70.0 days-84.0 days 43 7.07 x 1000 cells/ul 0.29 1.91 automated blood cell counting method 61429 527
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 -8.63 null 0.09 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56040 522
BN/NHsdMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70.0 days-84.0 days 43 0.12 x 1000 cells/ul 0.02 0.13 automated blood cell counting method 62269 527
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 60.83 % 3.75 15.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54840 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 66.8 % 3.88 17.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54841 522
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 0.31 umol/l 0.12 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54966 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 59.0 % 3.48 9.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56295 522
BN/NHsdMcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70.0 days-84.0 days 27 19.15 mmol/l 0.47 2.46 standard blood chemistry panel 61666 527
BN/NHsdMcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70.0 days-84.0 days 27 0.13 x 1000 cells/ul 0.03 0.14 automated blood cell counting method 61738 527
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 3.1 E-7mole 0.51 2.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56580 522
BN/NHsdMcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70.0 days-84.0 days 44 7.61 mg/dl 0.1 0.67 standard blood chemistry panel 61593 527
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 -6.67 null 0.11 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56975 522
BN/NHsdMcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70.0 days-84.0 days 27 3.6 g/dl 0.03 0.18 standard blood chemistry panel 61962 527
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70.0 days-84.0 days 26 167.77 U/l 9.72 49.55 standard blood chemistry panel 62034 527
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70.0 days-84.0 days 41 190.41 U/l 13.79 88.28 standard blood chemistry panel 62033 527
BN/NHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70.0 days-84.0 days 44 60.11 U/l 1.36 9.01 standard blood chemistry panel 60455 527
BN/NHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 17.87 pg 0.08 0.54 automated blood cell counting method 60527 527
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 111.8 mmHg 3.9 17.87 vascular indwelling catheter method left femoral artery 120.0 69527 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 22 0.88 mEq/d 0.06 0.27 unspecified method 0.0 urine potassium analysis umol/min 69473 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 21 serial mean 127.2 mmHg 4.1 18.79 vascular indwelling catheter method left femoral artery 10800.0 69515 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94.0 days 16 serial mean 370.1 beats/min 6.3 25.2 vascular indwelling catheter method left femoral artery 10800.0 69525 151
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 33 167.0 g 3.4 19.53 body weighing method 0.0 69441 151
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 24 370.0 mmol/l 14.3 70.06 unspecified method 0.0 urine sodium analysis 69453 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 109.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 3 h per day increase 66139 229
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 10 19.71 mg/d 4.56 14.41 automated urine analysis Moms and pups used in studies were fed Teklad 51762 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 112.16 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51830 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 3 97.79 mmHg 9.11 15.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51831 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 19.38 mmHg 3.3 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51873 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 3 1.49 ml/min 0.16 0.28 urine creatinine analysis Moms and pups used in studies were fed Teklad 51955 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 2 0.27 mg/dl 0.04 0.06 radioimmunoassay Moms and pups used in studies were fed Dyets 52043 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -6.25 beats/min 7.6 21.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52059 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 104.93 mmHg 2.81 7.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52091 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 11 39.43 mg/d 8.21 27.23 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52135 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 8 19.07 mEq/d 1.63 4.62 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52820 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 11 15.99 mEq/d 2.14 7.08 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52821 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 8 0.26 ng/ml/h 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52918 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 8 0.41 mg/dl 0.02 0.06 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52235 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 8 126.28 mmHg 8.23 23.29 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52572 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 9 363.56 beats/min 5.85 17.55 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52676 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 18 384.5 beats/min 7.1 30.12 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52677 482
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 10 73.25 mg/d 11.77 37.22 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52725 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 20.6 beats/min 13.45 26.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50513 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 443.08 beats/min 14.63 43.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50534 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 399.8 beats/min 23.32 46.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50533 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -24.45 beats/min 31.16 62.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50590 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 101.04 mmHg 1.9 5.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50651 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 33.62 mmHg 2.46 7.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50760 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 -9.46 mmHg 3.26 6.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50813 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 4.68 mmHg 2.12 5.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50920 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 110.47 mmHg 3.23 9.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50951 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 3 7.64 ng/ml/h 1.68 2.91 radioimmunoassay Moms and pups used in studies were fed Teklad 51015 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 1 8.99 ng/ml/h radioimmunoassay Moms and pups used in studies were fed Teklad 51014 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 7.32 mmHg 3.21 6.42 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51030 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 114.16 mmHg 3.59 7.17 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51151 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -35.16 beats/min 11.36 32.12 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51166 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 17.52 mmHg 4.28 11.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51195 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 3 0.95 mEq/d 0.15 0.26 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51275 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -55.31 beats/min 15.31 43.3 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51361 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 10 0.31 mg/d 0.05 0.17 automated urine analysis Moms and pups used in studies were fed Teklad 51478 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -28.81 beats/min 15.57 46.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51514 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.05 mEq/d 0.12 0.36 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51528 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 1.17 mEq/d 0.16 0.49 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51527 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 7.03 mmHg 3.14 9.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51602 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 103.82 mmHg 2.35 6.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51638 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.28 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51656 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 31.19 mmHg 2.1 4.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51667 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -8.48 beats/min 15.29 43.23 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50429 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 392.83 beats/min 17.75 46.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50482 481
BN/NHsdMcwi single kidney wet weight to body weight ratio controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 26 5.0 g/kg 0.2 1.02 post excision weight measurement 0.0 67287 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 127.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12006 229
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 114.0 mmHg 4.0 25.92 vascular indwelling catheter method femoral artery 14400.0 left femoral artery 12016 229
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 113.63 % 4.18 12.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17920 381
BN/NHsdMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70.0 days-84.0 days 44 0.15 g 0.0 0.03 digital scale post excision weight measurement 63332 529
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 2.07 g/mg 0.12 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 63190 528
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 2.01 E-7mole 0.22 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 63053 528
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 2.35 g/mg 0.11 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57395 522
BN/NHsdMcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 27 8.12 x 10E6 cells/ul 0.07 0.36 automated blood cell counting method 60610 527
BN/NHsdMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 43 44.38 % 0.38 2.47 automated blood cell counting method 60691 527
BN/NHsdMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70.0 days-84.0 days 27 20.93 mmol/l 0.61 3.17 standard blood chemistry panel 61132 527
BN/NHsdMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70.0 days-84.0 days 27 5.15 g/dl 0.05 0.24 standard blood chemistry panel 61286 527
BN/NHsdMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70.0 days-84.0 days 44 103.82 mmol/l 0.5 3.34 standard blood chemistry panel 62351 527
BN/NHsdMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70.0 days-84.0 days 27 105.04 mmol/l 0.42 2.17 standard blood chemistry panel 62352 527
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 0.02 10E-7mol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56253 522
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70.0 days-84.0 days 27 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 62188 527
BN/NHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70.0 days-84.0 days 26 37.46 U/l 2.48 12.62 standard blood chemistry panel 61502 527
BN/NHsdMcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70.0 days-84.0 days 27 7.45 mg/dl 0.09 0.49 standard blood chemistry panel 61594 527
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 -6.87 null 0.08 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56976 522
BN/NHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70.0 days-84.0 days 27 43.7 U/l 1.39 7.2 standard blood chemistry panel 60456 527
BN/NHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 17.76 pg 0.07 0.39 automated blood cell counting method 60528 527
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 118.9 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 120.0 69529 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 69535 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 128.6 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69537 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 137.4 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69545 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 69547 151
BN/NHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 25 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 mg/min 69477 151
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 27 0.86 g 0.03 0.16 post excision weight measurement 0.0 69505 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 17 serial mean 134.6 mmHg 4.1 16.9 vascular indwelling catheter method left femoral artery 10800.0 69521 151
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 89.0 days-92.0 days 24 168.0 g 2.3 11.27 body weighing method 0.0 69439 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 110.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 65462 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 72.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 65464 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 89.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 65466 151
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 5 1.48 ng/ml/h 0.33 0.74 radioimmunoassay Moms and pups used in studies were fed Teklad 51845 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -7.05 beats/min 10.76 21.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51858 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -26.7 beats/min 9.39 18.78 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51928 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.94 mmHg 2.68 5.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51971 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 91.79 mmHg 3.28 6.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52009 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -6.75 beats/min 8.96 17.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52058 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 104.25 mmHg 3.14 6.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52092 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 9 110.84 mmHg 1.12 3.36 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52874 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 21 0.95 mEq/d 0.05 0.24 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52973 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 8 1.06 mEq/d 0.04 0.12 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52332 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 7 1.23 ml/min 0.15 0.4 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52380 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 8 2.55 ml/min 0.26 0.72 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52379 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 8 120.84 mmHg 2.6 7.37 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52571 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 10 25.2 mEq/d 2.71 8.56 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52776 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -47.96 beats/min 18.32 51.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50589 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 106.57 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50650 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 39.26 mmHg 3.2 8.46 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50664 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 39.82 mmHg 2.4 6.8 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50665 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -25.21 beats/min 19.43 54.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50728 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -12.7 beats/min 20.48 40.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50727 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 101.3 mmHg 2.17 6.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50745 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 34.94 mmHg 9.38 18.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50759 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.65 mmHg 0.84 1.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50782 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 375.46 beats/min 8.18 18.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50889 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.4 mmHg 1.79 3.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50921 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 13.07 mmHg 1.59 4.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51031 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 68.68 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51097 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 3 -11.61 beats/min 15.08 26.12 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51098 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 431.06 beats/min 10.72 30.33 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51124 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 384.75 beats/min 35.54 71.08 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51123 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.88 mmHg 3.75 7.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51137 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -24.8 beats/min 9.84 19.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51209 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -11.35 beats/min 12.39 24.77 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51241 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 3 0.3 mg/dl 0.02 0.04 radioimmunoassay Moms and pups used in studies were fed Teklad 51322 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -38.7 beats/min 18.21 36.42 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51513 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 9 0.78 mg/d 0.26 0.77 automated urine analysis Moms and pups used in studies were fed Dyets 51572 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -45.27 beats/min 22.01 44.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50363 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.61 mmHg 1.8 5.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50378 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 90.0 days-94.0 days 11 0.4 mg/dl 0.06 0.2 plasma creatinine analysis 0.0 plasma creatinine analysis 66153 151
BN/NHsdMcwi plasma triglyceride level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood triglyceride amount female 92.0 days-94.0 days 7 0.72 mmol/l 0.11 0.3 plasma triglyceride analysis 0.0 67291 151
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 33 175.0 g 3.0 17.23 body weighing method 0.0 after catheterization and jacket attachment 67293 151
BN/NHsdMcwi heart wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart mass female 97.0 days-101.0 days 27 0.69 g 0.02 0.1 post excision weight measurement 0.0 67295 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 130.0 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11849 151
BN/NHsdMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70.0 days-84.0 days 29 0.11 g 0.0 0.01 digital scale post excision weight measurement 63333 529
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70.0 days-84.0 days 29 0.52 g 0.01 0.04 digital scale post excision weight measurement 63405 529
BN/NHsdMcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 26 20.38 cm 0.14 0.73 in vivo ruler method 63569 529
BN/NHsdMcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70.0 days-84.0 days 26 145.0 mg/dl 3.68 18.76 standard blood chemistry panel 62516 527
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 5 148.8 g 1.85 4.15 whole body digital scale 62966 528
BN/NHsdMcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 43 8.33 x 10E6 cells/ul 0.08 0.5 automated blood cell counting method 60609 527
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70.0 days-84.0 days 44 0.31 mg/dl 0.01 0.09 automated plasma creatinine analysis 61059 527
BN/NHsdMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70.0 days-84.0 days 44 23.16 mmol/l 0.45 2.99 standard blood chemistry panel 61131 527
BN/NHsdMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70.0 days-84.0 days 44 5.82 g/dl 0.05 0.33 standard blood chemistry panel 61285 527
BN/NHsdMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70.0 days-84.0 days 27 4.18 mmol/l 0.09 0.45 flame atomic emission spectrometry 61358 527
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 -6.8 null 0.1 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56165 522
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 -6.97 null 0.07 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56166 522
BN/NHsdMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70.0 days-84.0 days 27 0.1 x 1000 cells/ul 0.02 0.09 automated blood cell counting method 62270 527
BN/NHsdMcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70.0 days-84.0 days 44 59.52 mg/dl 0.86 5.72 standard blood chemistry panel 62423 527
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 0.04 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56252 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 54.5 % 9.09 22.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56296 522
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 99.2 % 0.44 1.99 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56327 522
BN/NHsdMcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70.0 days-84.0 days 44 19.23 mmol/l 0.52 3.42 standard blood chemistry panel 61665 527
BN/NHsdMcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70.0 days-84.0 days 43 0.13 x 1000 cells/ul 0.02 0.12 automated blood cell counting method 61737 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 47.43 % 4.93 13.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55095 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 1.89 E-7mole 0.46 2.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56581 522
BN/NHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70.0 days-84.0 days 41 51.83 U/l 5.79 37.07 standard blood chemistry panel 61501 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 43.77 % 9.19 24.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57158 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 47.5 % 5.6 13.71 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57159 522
BN/NHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 23 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 ug/min 69462 151
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 22 100.4 mmol/l 6.5 30.49 unspecified method 0.0 urine sodium analysis 69466 151
BN/NHsdMcwi hematocrit controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. erythrocyte quantity female 89.0 days-92.0 days 15 41.6 % 0.4 1.55 hematocrit analysis 0.0 69481 151
BN/NHsdMcwi plasma high density lipoprotein cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood HDL cholesterol amount female 92.0 days-94.0 days 9 44.2 mg/dl 2.2 6.6 plasma high-density lipoprotein-cholesterol measurement test 0.0 69503 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 20 serial mean 140.6 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 10800.0 69509 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 20 serial mean 103.2 mmHg 2.8 12.52 vascular indwelling catheter method left femoral artery 10800.0 69511 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 17 serial mean 91.6 mmHg 3.6 14.84 vascular indwelling catheter method left femoral artery 10800.0 69523 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 111.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 69447 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-91.0 days 18 serial mean 386.0 beats/min 4.1 17.39 vascular indwelling catheter method left femoral artery 0.0 69449 151
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 24 6.35 mEq/d 0.35 1.74 unspecified method 0.0 urine sodium analysis umol/min 69459 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 25.0 mmHg 3.0 13.42 vascular indwelling catheter method left femoral artery 0.0 67303 151
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 16.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 66149 151
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95.0 days 11 9.6 ng/ml/h 1.0 3.32 ex vivo blood analysis 0 65474 151
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 4.5 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 0.0 left femoral artery increase 64928 229
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -38.48 beats/min 13.18 37.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51730 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 10 10.61 mg/d 1.41 4.46 automated urine analysis Moms and pups used in studies were fed Teklad 51761 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 30.33 mmHg 2.51 5.03 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51778 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 16.08 mmHg 3.41 9.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51779 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 11.12 beats/min 17.12 51.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51859 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 10.9 mEq/d 0.8 2.54 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51894 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 91.89 mmHg 3.36 7.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52008 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 3 12.33 mEq/d 1.71 2.97 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52021 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 7 0.33 mg/dl 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52284 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 8 5.41 mg/d 1.01 2.85 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52426 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 11 7.16 mg/d 2.64 8.76 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52427 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 15 4.4 ng/ml/h 1.26 4.87 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52481 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 21 2.16 mg/d 0.38 1.73 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52626 482
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 21 34.79 mg/d 5.13 23.51 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52726 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 32.45 beats/min 10.27 29.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50514 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 3 -2.03 mmHg 7.23 12.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50637 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 3.46 mmHg 1.52 4.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50781 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -28.94 beats/min 6.27 14.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50988 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 3 0.8 ml/min 0.26 0.45 urine creatinine analysis Moms and pups used in studies were fed Teklad 51064 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 0.1 mmHg 1.74 4.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51136 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -1.39 beats/min 7.41 20.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51240 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 409.37 beats/min 12.52 35.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51292 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 408.04 beats/min 7.45 21.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51291 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 20.68 mmHg 2.71 8.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51347 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 39.47 mmHg 5.6 11.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51431 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 2 1.55 ml/min 0.17 0.24 urine creatinine analysis Moms and pups used in studies were fed Dyets 51548 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 4 1.22 mg/d 0.23 0.45 automated urine analysis Moms and pups used in studies were fed Dyets 51571 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 23.04 mmHg 2.89 8.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51666 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 402.34 beats/min 10.96 30.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50483 481
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 27.0 mmHg 2.0 8.94 vascular indwelling catheter method left femoral artery 0.0 67299 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 19 -1.4 ml/min/g 0.2 0.87 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67307 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 92.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11851 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 110.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11853 151
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 92.0 days 14 1.4 ng/ml/h 0.4 1.5 ex vivo blood analysis enzyme assay 13308 151
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70.0 days-84.0 days 29 0.35 g 0.0 0.02 digital scale post excision weight measurement 63795 529
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 -8.13 null 0.03 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 63123 528
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.98 null 0.1 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 62874 528
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 1.91 g/mg 0.08 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57394 522
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70.0 days-84.0 days 27 0.29 mg/dl 0.02 0.08 automated plasma creatinine analysis 61060 527
BN/NHsdMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70.0 days-84.0 days 43 4.8 mmol/l 0.09 0.62 flame atomic emission spectrometry 61357 527
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 -8.92 null 0.07 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56041 522
BN/NHsdMcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70.0 days-84.0 days 27 54.26 mg/dl 1.17 6.06 standard blood chemistry panel 62424 527
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 99.19 % 0.38 1.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56328 522
BN/NHsdMcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70.0 days-84.0 days 44 141.27 mmol/l 0.43 2.86 flame atomic emission spectrometry 61839 527
BN/NHsdMcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70.0 days-84.0 days 27 140.81 mmol/l 0.36 1.86 flame atomic emission spectrometry 61840 527
BN/NHsdMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70.0 days-84.0 days 43 5.05 x 1000 cells/ul 0.24 1.54 automated blood cell counting method 62115 527
BN/NHsdMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70.0 days-84.0 days 27 5.94 x 1000 cells/ul 0.39 2.0 automated blood cell counting method 62116 527
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70.0 days-84.0 days 44 25.52 mg/dl 0.63 4.17 standard blood chemistry panel 60209 527
BN/NHsdMcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 14.87 g/dl 0.11 0.74 automated blood cell counting method 60363 527
BN/NHsdMcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70.0 days-84.0 days 44 3.89 g/dl 0.03 0.23 standard blood chemistry panel 61961 527
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 139.1 mmHg 3.6 16.5 vascular indwelling catheter method left femoral artery 120.0 69533 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 111.3 mmHg 4.6 21.08 vascular indwelling catheter method left femoral artery 120.0 69541 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 16 serial mean 118.6 mmHg 3.4 13.6 vascular indwelling catheter method left femoral artery 120.0 69543 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 69549 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92.0 days-94.0 days 25 9.86 ml/d 0.4 2.0 urine volume measurement method 0.0 needs ml/d default 69464 151
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92.0 days-94.0 days 8 1.1 ml/min 0.2 0.57 urine creatinine analysis 0.0 mg/min 69479 151
BN/NHsdMcwi right kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 27 0.76 g 0.02 0.1 post excision weight measurement 0.0 69507 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 92.0 days 21 serial mean 386.5 beats/min 9.6 43.99 vascular indwelling catheter method left femoral artery 10800.0 69513 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 21 serial mean 89.6 mmHg 2.5 11.46 vascular indwelling catheter method left femoral artery 10800.0 69517 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 96.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 69445 151
BN/NHsdMcwi urine total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (0.4 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 20 0.24 mg/ml 0.05 0.22 urine total protein analysis 0.0 mg/ml 69457 151