Phenominer Database Results (486 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 17.16 mmHg 1.32 2.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15146 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 21 0.23 degrees C 0.14 0.66 digital rectal thermometry Moms and pups used in studies were fed Teklad 15655 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 14 413.27 beats/min 9.52 35.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15904 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 384.04 beats/min 13.45 40.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14678 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 9 1.96 ml/min 0.15 0.44 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52142 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 9 0.49 ng/ml/h 0.16 0.49 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52436 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 10 41.24 mg/d 7.04 22.27 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52585 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 9 25.78 mmHg 0.57 1.7 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17221 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 16 508.54 beats/min 11.71 46.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13786 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19759 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19764 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 123.56 mmHg 2.52 9.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19842 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 400.41 beats/min 5.58 18.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20895 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 119.35 % 2.9 11.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53821 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 -0.05 null 0.02 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19923 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 16 111.98 mmHg 1.74 6.96 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20042 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20598 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 148.65 beats/min 13.67 23.67 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18359 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 99.36 breaths/min 3.24 12.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18396 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 27.96 mmHg 1.21 2.43 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18823 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 16 125.53 mmHg 2.12 8.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18929 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 32.29 g/dl 0.14 0.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 37313 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 79.6 U/l 3.97 12.55 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37443 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 119.34 % 6.67 23.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18533 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 49.27 ml/min 2.43 8.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18652 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 434.17 beats/min 16.01 45.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17482 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 14 9.56 mg/dl 0.1 0.39 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36610 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 10 5.67 x 1000 cells/ul 0.27 0.85 automated blood cell counting method Moms and pups used in studies were fed Teklad 36854 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 10 3.76 x 1000 cells/ul 0.27 0.86 automated blood cell counting method Moms and pups used in studies were fed Teklad 36862 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 53.17 mmHg 1.44 4.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20449 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 15 1.02 g 0.04 0.17 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49046 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 15 198.2 g 4.2 16.3 whole body digital scale Moms and pups used in studies were fed Teklad 49494 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 15 163.2 g 2.0 7.9 whole body digital scale Moms and pups used in studies were fed Teklad 49502 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 13.94 IU/g 2.2 6.23 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49832 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 14 880.98 s 54.21 202.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50105 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 %change=VE during 2-3 min hypercapnia/control during standard conditions 319.44 % 14.39 65.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19197 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42868 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 130.03 % 5.02 19.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54394 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 10 104.5 mmol/l 0.52 1.65 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39991 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 10 4.49 mmol/l 0.07 0.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43312 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 4.05 g/dl 0.06 0.18 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40400 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 38.7 U/l 2.52 7.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40704 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 7 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59343 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 0.92 g/kg 0.04 0.14 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59439 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 9.04 mg/dl 0.3 0.94 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37820 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 14 4.51 mmol/l 0.2 0.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38052 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 10 55.59 fl 0.1 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 38632 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 14 59.86 fl 0.96 3.58 automated blood cell counting method Moms and pups used in studies were fed Teklad 38731 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 7.75 x 10E6 cells/ul 0.09 0.29 automated blood cell counting method Moms and pups used in studies were fed Teklad 41962 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 15 5.82 g/kg 0.12 0.48 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45592 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 33.9 % 5.61 20.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48517 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 10 45.66 % 0.49 1.55 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57472 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 10 43.99 % 0.45 1.43 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57480 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 13 -7.21 null 0.09 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55259 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 10.34 ml/min/kg 0.51 1.44 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57786 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -7.09 mmHg 0.39 0.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16309 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 -4.9 mmHg 1.3 1.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16315 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 19 100.21 mmHg 1.32 5.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16387 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 14 211.1 g 7.0 26.0 whole body digital scale Moms and pups used in studies were fed Teklad 55402 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 14 1.59 g/mg 0.1 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55772 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.71 degrees C 0.24 0.84 digital rectal thermometry Moms and pups used in studies were fed Teklad 16802 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 -7.36 null 0.11 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56081 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 8 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58475 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 0.03 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56235 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 99.64 % 0.36 1.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56305 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.37 null 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58723 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 44.8 % 4.08 12.91 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55049 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 40.23 % 4.6 16.59 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55078 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 0.88 E-7mole 0.18 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56496 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 8.39 ml/min/kg 0.91 2.41 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59979 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -7.15 null 0.08 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56891 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 48.64 % 5.0 18.71 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57208 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.51 ml 0.04 0.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17360 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 136.86 mmHg 4.19 15.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45719 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 13 7.73 ml/min/g 0.51 1.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44708 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 14 10.44 ml/min/g 0.5 1.88 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46856 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 15 11.14 ml/min/g 0.31 1.2 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46860 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 15 4.6 g/kg 0.15 0.57 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 46967 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 56.21 mmHg 6.25 23.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47901 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 14 105.53 mmHg 4.35 16.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44801 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 113.07 mmHg 3.05 11.43 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44805 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 41.68 % 4.12 15.43 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47063 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 48.49 % 4.72 17.67 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47067 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 5.81 mmHg 0.1 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47187 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 12 267.84 beats/min 40.9 141.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45134 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 56.52 mmHg 3.21 11.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46407 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 50.68 mmHg 8.4 27.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45256 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 -0.12 degrees C 0.16 0.65 digital rectal thermometry Moms and pups used in studies were fed Teklad 15659 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 0.34 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15383 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 18 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14586 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 14 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14592 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 14 369.92 beats/min 5.45 20.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14674 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.37 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15223 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 95.87 breaths/min 4.1 16.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14925 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 10 184.5 mg/d 28.5 90.11 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52685 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 164.69 % 5.48 21.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54290 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 106.25 % 3.64 12.62 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54057 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 118.83 breaths/min 6.66 23.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14784 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 14 28.31 mmHg 1.19 4.47 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13422 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 37.43 degrees C 0.14 0.55 digital rectal thermometry Moms and pups used in studies were fed Teklad 13549 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 124.43 mmHg 3.67 10.39 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14309 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 21 154.4 breaths/min 3.34 15.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17097 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.41 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19730 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 7.41 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19736 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 122.64 mmHg 1.51 4.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19846 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 16 10.57 mmHg 1.18 4.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20714 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 98.61 ml/min 4.7 21.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20747 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 434.16 beats/min 9.9 28.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20900 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 -0.05 null 0.01 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19917 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 17 115.22 mmHg 1.77 7.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20036 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 14 -2.59 mmHg 0.98 3.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20076 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20603 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 -5.01 mmHg 0.58 1.74 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19609 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 19 38.35 degrees C 0.13 0.58 digital rectal thermometry Moms and pups used in studies were fed Teklad 17630 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 16 432.59 beats/min 5.92 23.66 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17734 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.42 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17968 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.53 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17022 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 102.56 mmHg 2.3 7.28 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18842 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 114.0 U/l 8.91 28.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36369 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 89.7 mg/dl 3.09 9.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37087 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 6.25 g/dl 0.05 0.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37191 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 21 37.24 degrees C 0.15 0.69 digital rectal thermometry Moms and pups used in studies were fed Teklad 19055 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 146.1 mmol/l 0.43 1.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36483 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 10 9.8 mg/dl 0.09 0.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36744 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 10 9.61 mg/dl 0.14 0.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36752 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 -50.07 mmHg 3.27 9.81 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19438 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 43.15 ml/min 2.38 8.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20198 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 193.89 beats/min 16.01 59.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48935 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 14 20.46 % 3.87 14.49 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49382 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 15 19.68 % 2.92 11.32 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49386 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 13 10.36 % 2.48 8.95 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49684 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 103.49 mmHg 5.02 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49878 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 14 53.43 mmHg 3.22 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49987 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 %change=VE during 2-3 min hypercapnia/control during standard conditions 298.49 % 18.01 72.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19201 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 60.38 fl 0.8 2.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 38735 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 53.86 % 1.7 5.38 automated blood cell counting method Moms and pups used in studies were fed Teklad 38981 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 10 78.3 U/l 6.16 19.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42402 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42639 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 14 145.29 mmol/l 0.91 3.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39374 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 64.9 U/l 2.73 8.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42760 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 32.03 g/dl 0.11 0.35 automated blood cell counting method Moms and pups used in studies were fed Teklad 39767 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 10 0.65 x 1000 cells/ul 0.09 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 43214 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 180.39 % 11.78 47.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54496 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 14.74 g/dl 0.12 0.39 automated blood cell counting method Moms and pups used in studies were fed Teklad 40087 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 10 0.49 x 1000 cells/ul 0.08 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 40279 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 10 1.19 mg/kg 0.28 0.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59150 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 10 55.21 % 1.97 6.24 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59243 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59537 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 37.1 U/l 2.42 7.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37700 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 10 154.3 mg/dl 3.59 11.35 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41179 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.49 g/kg 0.05 0.17 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59647 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.35 null 0.04 0.1 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59766 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 16.71 g/dl 0.65 2.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 37954 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 4.26 mmol/l 0.11 0.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38056 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41389 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 108.2 mg/dl 1.38 4.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38426 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 159.6 mg/dl 8.38 26.5 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38520 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 10 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 41637 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 12 131.23 mmHg 3.6 12.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45490 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 134.51 mmHg 5.71 19.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45494 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 1122.58 s 48.79 182.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46534 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 250.09 beats/min 11.1 41.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47572 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 62.11 % 10.41 38.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48742 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 1.26 g/mg 0.06 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57310 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 1.57 g/mg 0.07 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57318 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 8.38 ml/min/kg 0.35 0.99 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57584 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 32.98 ml/min 1.88 8.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16133 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 14 12.07 mmHg 1.62 6.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16279 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.49 ml 0.04 0.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16463 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 16 0.04 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54650 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 52.09 % 4.31 14.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54764 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -7.27 null 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56089 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 0.06 umol/l 0.01 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54882 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 39.62 % 4.85 17.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56278 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.4 null 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58719 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 15 292.6 g 3.2 12.2 whole body digital scale Moms and pups used in studies were fed Teklad 55161 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 0.91 E-7mole 0.19 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56504 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 43.21 % 3.14 11.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57200 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 30.84 mmHg 0.91 2.87 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16044 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 14.82 ml/min/g 0.51 1.93 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46643 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 14 12.9 ml/min/g 0.79 2.95 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46639 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 15 57.07 mmHg 3.12 12.09 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48023 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 6.6 ml/min/g 0.55 2.06 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46191 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 231.7 beats/min 13.32 49.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48183 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 15 254.01 beats/min 6.8 26.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48187 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 36.26 % 4.67 16.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46309 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 15 post-ischemic value/pre-ischemic value x 100% 72.71 % 7.95 30.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48396 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 123.06 mmHg 2.43 8.05 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15066 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 130.43 mmHg 3.29 9.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15071 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 15 30.86 mmHg 1.26 4.87 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14459 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 102.08 ml/min 4.79 21.96 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14486 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 80.15 ml/min 6.29 25.18 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14490 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 19 0.65 degrees C 0.19 0.84 digital rectal thermometry Moms and pups used in studies were fed Teklad 15991 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.47 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15219 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 8 1.68 ml/min 0.46 1.31 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52146 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 9 181.29 mmHg 4.8 14.41 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52834 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 8 0.34 mg/dl 0.04 0.1 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52195 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 10 415.28 beats/min 9.27 29.32 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52632 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 12 15.1 mEq/d 1.32 4.57 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52732 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 10 10.85 mEq/d 1.44 4.55 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52736 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 18 -0.02 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14747 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 117.97 breaths/min 3.71 14.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14780 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 16 heart rate during walking-heart rate during rest 90.48 beats/min 9.72 38.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13383 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 18 28.86 mmHg 0.67 2.85 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13416 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 152.04 % 5.31 20.57 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13666 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 %change=VE during7-9 min hypercapnia/control during standard conditions 310.65 % 17.22 78.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14184 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 113.53 % 8.09 28.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53824 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 117.95 % 3.6 13.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53953 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 118.68 % 3.63 12.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53956 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 18 -3.54 mmHg 0.55 2.35 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20070 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 19 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20142 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 15 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20148 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 -6.14 mmHg 1.06 3.17 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19614 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 38.48 degrees C 0.16 0.65 digital rectal thermometry Moms and pups used in studies were fed Teklad 17636 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 127.12 mmHg 2.33 5.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17764 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 24 299.4 g 4.2 20.6 whole body digital scale Moms and pups used in studies were fed Dyets 17803 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17027 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 108.65 breaths/min 8.93 30.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18400 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 97.96 mmHg 2.05 6.49 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18847 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 14 179.79 U/l 17.52 65.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36365 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 10 6.25 g/dl 0.05 0.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37183 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 32.45 g/dl 0.12 0.38 automated blood cell counting method Moms and pups used in studies were fed Teklad 37321 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 37.55 degrees C 0.16 0.65 digital rectal thermometry Moms and pups used in studies were fed Teklad 19059 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 396.45 beats/min 10.38 31.13 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17477 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 10 9.57 mg/dl 0.1 0.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36614 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 123.6 breaths/min 10.34 35.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18255 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 0.26 degrees C 0.17 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 20295 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 0.18 degrees C 0.2 0.69 digital rectal thermometry Moms and pups used in studies were fed Teklad 20299 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 9.56 IU/g 1.64 4.91 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49838 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 15 865.18 s 35.85 138.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50109 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 1097.74 s 40.71 152.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50213 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 14 19.5 mmol/l 0.91 3.39 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42048 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 14 3.7 g/dl 0.09 0.33 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42219 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 19.34 pg 0.28 1.07 automated blood cell counting method Moms and pups used in studies were fed Teklad 42531 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 19.32 pg 0.21 0.67 automated blood cell counting method Moms and pups used in studies were fed Teklad 42535 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42631 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 24.0 mmol/l 0.37 1.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43124 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 104.3 mmol/l 0.76 2.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39999 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 4.08 mmol/l 0.12 0.36 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43320 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 175.1 % 6.23 24.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53705 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 17.95 pg 0.07 0.22 automated blood cell counting method Moms and pups used in studies were fed Teklad 40183 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 18.42 pg 0.09 0.29 automated blood cell counting method Moms and pups used in studies were fed Teklad 40191 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 10 0.88 mg/kg 0.11 0.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59158 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 8 56.23 % 0.79 2.23 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59247 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 8 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59351 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 14 9.13 mg/dl 0.18 0.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37580 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 23.4 mg/dl 1.88 5.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40818 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 14 6.01 x 1000 cells/ul 0.56 2.11 automated blood cell counting method Moms and pups used in studies were fed Teklad 40912 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 10 5.34 x 1000 cells/ul 0.64 2.01 automated blood cell counting method Moms and pups used in studies were fed Teklad 40916 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59533 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 2.2 g/dl 0.03 0.08 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41020 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 17.25 g/dl 0.51 1.63 automated blood cell counting method Moms and pups used in studies were fed Teklad 37958 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 45.66 % 0.49 1.55 automated blood cell counting method Moms and pups used in studies were fed Teklad 41287 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 22.9 mmol/l 0.57 1.79 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38251 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 10 4.31 x 1000 cells/ul 0.51 1.62 automated blood cell counting method Moms and pups used in studies were fed Teklad 41493 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 14 153.43 mg/dl 4.08 15.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38516 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 56.76 fl 0.17 0.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 38640 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 15 1.15 g 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45391 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 15 1109.51 s 30.17 116.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46538 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 255.94 beats/min 9.61 35.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47568 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 30.39 % 6.29 23.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48513 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 70.53 % 6.49 24.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48746 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 200.14 beats/min 10.63 39.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48931 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.2 null 0.01 0.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57886 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 29.04 ml/min/kg 2.45 7.35 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57989 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -6.94 null 0.1 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55601 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.44 null 0.03 0.1 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58103 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 43.24 ml/min/kg 4.78 13.51 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58220 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 37.49 degrees C 0.17 0.68 digital rectal thermometry Moms and pups used in studies were fed Teklad 16798 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 190.9 g 1.5 4.8 whole body digital scale Moms and pups used in studies were fed Teklad 58331 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 13 0.08 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54658 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 45.83 % 4.05 14.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54756 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -8.48 null 0.05 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56018 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 -8.57 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56023 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 11.32 ml/min/kg 1.06 2.79 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58608 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 31.92 % 3.38 12.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55045 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 15 196.5 g 3.4 13.0 whole body digital scale Moms and pups used in studies were fed Teklad 55168 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.11 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59881 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 35.3 % 5.41 17.11 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57141 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 32.1 mmHg 0.85 2.7 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16049 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 15 5.93 g/kg 0.17 0.66 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45600 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 11.43 IU/g 0.72 1.77 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45697 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 136.71 mmHg 5.52 19.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45715 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 60.73 mmHg 4.11 14.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47687 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 15 222.1 g 6.1 23.5 whole body digital scale Moms and pups used in studies were fed Teklad 47789 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 14 43.34 mmHg 3.66 13.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47897 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 14 6.16 ml/min/g 0.44 1.64 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46187 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 13 273.2 beats/min 40.93 147.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45138 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 12 0.18 IU/g 0.06 0.2 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47432 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 14 113.76 mmHg 1.65 6.16 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15038 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 22.43 mmHg 4.83 8.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15152 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 422.85 beats/min 10.01 30.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15908 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 10 190.68 mmHg 5.29 16.74 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52830 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 12 1.33 mEq/d 0.07 0.25 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52928 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 9 427.95 beats/min 12.74 38.22 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52636 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 12 302.91 mg/d 22.58 78.21 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52681 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 21 162.9 % 6.52 29.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54287 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 113.11 % 3.26 12.62 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54054 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 125.46 mmHg 2.74 8.22 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13465 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 21 37.48 degrees C 0.1 0.48 digital rectal thermometry Moms and pups used in studies were fed Teklad 13545 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 %change=VE during7-9 min hypercapnia/control during standard conditions 292.6 % 18.76 75.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14188 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 121.05 mmHg 3.21 9.64 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14304 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 155.46 breaths/min 4.66 18.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17101 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 137.06 % 8.57 29.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13670 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 527.25 beats/min 6.51 25.22 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13791 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 9.95 mmHg 3.06 11.87 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20720 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 19.43 mmHg 4.18 5.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20876 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 117.61 mmHg 2.16 4.32 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19974 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 114.93 mmHg 4.97 7.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19980 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 132.23 mmHg 3.83 6.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17770 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 19 194.7 g 3.7 16.2 whole body digital scale Moms and pups used in studies were fed Dyets 17807 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 19 37.71 degrees C 0.12 0.53 digital rectal thermometry Moms and pups used in studies were fed Teklad 18114 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 37.67 degrees C 0.18 0.72 digital rectal thermometry Moms and pups used in studies were fed Teklad 18120 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 21 165.45 breaths/min 5.58 25.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16897 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 96.82 beats/min 16.87 37.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18353 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 23.18 mmHg 2.28 3.22 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18829 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 122.22 mmHg 3.42 13.23 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18935 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 14 5.91 g/dl 0.11 0.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36948 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 14 92.5 mg/dl 2.53 9.46 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37083 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 135.05 % 5.32 20.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18529 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 62.79 ml/min 3.82 14.79 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18648 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 128.13 breaths/min 4.86 18.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18251 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 55.63 ml/min 3.32 12.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20194 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 56.77 mmHg 1.99 5.98 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20454 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 15 0.88 g 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49050 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 14 795.77 s 51.48 192.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49285 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 14 7.8 % 2.44 9.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49688 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 12 100.35 mmHg 12.99 45.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49874 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 14 51.29 mmHg 4.18 15.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49983 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 1130.56 s 41.48 155.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50217 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 4.03 g/dl 0.06 0.19 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42223 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 14 106.79 mmol/l 0.49 1.85 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39103 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 68.1 U/l 2.01 6.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42410 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 14 8.61 x 10E6 cells/ul 0.24 0.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 39223 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 13 85.0 U/l 4.14 14.92 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42756 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 14 0.27 mg/dl 0.02 0.09 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39562 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.33 mg/dl 0.03 0.08 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39566 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 14 0.36 x 1000 cells/ul 0.07 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 39660 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 10 0.34 x 1000 cells/ul 0.07 0.22 automated blood cell counting method Moms and pups used in studies were fed Teklad 39664 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 32.41 g/dl 0.18 0.67 automated blood cell counting method Moms and pups used in studies were fed Teklad 39763 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 22.0 mmol/l 0.37 1.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42983 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 10 6.96 x 1000 cells/ul 0.34 1.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 39870 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 21 173.52 % 7.02 32.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53702 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 238.5 g 4.9 15.4 whole body digital scale Moms and pups used in studies were fed Teklad 59048 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 14 2.21 g/dl 0.05 0.18 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40536 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 10 53.4 U/l 5.64 17.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37692 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.07 g/kg 0.03 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59447 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 10 8.69 mg/dl 0.21 0.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37812 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 10 2.43 g/dl 0.08 0.24 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41012 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 137.9 mg/dl 3.44 10.88 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41187 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 44.02 % 0.48 1.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 41295 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method Moms and pups used in studies were fed Teklad 41397 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 14 23.43 mmol/l 0.8 3.01 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38247 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 14 4.93 x 1000 cells/ul 0.47 1.75 automated blood cell counting method Moms and pups used in studies were fed Teklad 41489 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 13 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41633 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 10 17.0 mg/dl 0.65 2.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41737 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 18.4 mg/dl 0.88 2.8 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41745 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 8.21 x 10E6 cells/ul 0.08 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 41954 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 15 0.97 g 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45395 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 131.21 mmHg 5.59 20.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48610 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 16 -7.46 null 0.03 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55251 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 12.83 ml/min/kg 0.82 2.46 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57790 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 15 101.86 mmHg 1.56 6.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16393 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 16 282.9 g 3.9 15.5 whole body digital scale Moms and pups used in studies were fed Teklad 55395 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 37.75 degrees C 0.08 0.31 digital rectal thermometry Moms and pups used in studies were fed Teklad 16558 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 41.21 ml/min 1.76 6.83 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16676 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 36.91 ml/min 2.34 8.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16680 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 16 0.04 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55734 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 16 1.47 g/mg 0.08 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55764 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 28.25 ml/min/kg 2.85 7.53 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58212 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 1.55 E-7mole 0.32 1.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55878 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 16 -8.53 null 0.09 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54608 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -8.61 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54613 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58479 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 14.25 ml/min/kg 1.1 3.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58616 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.04 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56230 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 1.38 mg/kg 0.29 0.78 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58892 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 35.07 % 3.43 12.82 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55073 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 42.4 % 5.11 16.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55137 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 37.42 % 4.68 16.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57136 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 38.62 % 2.54 9.15 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57168 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 0.64 ml 0.03 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17356 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 125.1 mmHg 3.22 9.67 balloon tipped catheter with pressure transducer in isolated perfused heart 46736 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 128.67 mmHg 5.71 19.77 balloon tipped catheter with pressure transducer in isolated perfused heart 46740 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 56.86 mmHg 5.12 19.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47691 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 13 5.8 ml/min/g 0.47 1.7 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44704 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 15 4.99 g/kg 0.09 0.34 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 46975 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 14 54.64 mmHg 4.25 15.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48019 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 59.38 % 3.7 13.86 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46052 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 14 5.52 mmHg 0.18 0.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47183 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 102.49 % 15.94 59.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48285 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 13 0.17 IU/g 0.04 0.14 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47282 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 14 0.22 IU/g 0.05 0.19 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47290 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 46.97 mmHg 6.46 23.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45260 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 18 110.53 mmHg 2.28 9.68 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15032 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.28 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15387 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 19 32.3 mmHg 0.57 2.49 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14453 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 0.81 degrees C 0.17 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 15997 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 21 97.71 breaths/min 4.18 19.17 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14921 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 10 0.95 mEq/d 0.12 0.39 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52932 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 9 0.38 mg/dl 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52191 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 8 1.01 ng/ml/h 0.34 0.95 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52440 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 12 86.57 mg/d 11.34 39.28 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52581 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 184.67 % 4.6 21.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54153 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 173.11 % 10.96 43.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54156 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 14 -0.01 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14753 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 heart rate during walking-heart rate during rest 93.08 beats/min 5.2 20.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13388 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 129.83 mmHg 2.9 10.85 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13461 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 10 24.78 mmHg 1.28 4.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17216 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.49 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13909 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.41 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13913 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 78.27 ml/min 6.42 25.66 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20751 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 11.28 mmHg 3.78 7.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20870 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 510.22 beats/min 28.21 63.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19955 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 574.27 beats/min 5.79 10.03 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19961 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 17 416.69 beats/min 12.51 51.57 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17728 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.35 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17972 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 165.67 breaths/min 6.37 25.47 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16901 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 6.19 g/dl 0.1 0.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36952 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 10 141.9 U/l 7.21 22.81 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37435 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 10 146.2 mmol/l 0.44 1.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36475 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 -40.93 mmHg 3.13 9.38 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19443 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 5.76 mmHg 0.04 0.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49163 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 5.91 mmHg 0.12 0.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49167 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 14 778.86 s 50.73 189.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49289 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 10 0.8 x 1000 cells/ul 0.08 0.24 automated blood cell counting method Moms and pups used in studies were fed Teklad 38881 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 10 0.39 x 1000 cells/ul 0.03 0.08 automated blood cell counting method Moms and pups used in studies were fed Teklad 38889 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 18.2 mmol/l 0.94 2.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42052 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 14 51.74 % 2.06 7.71 automated blood cell counting method Moms and pups used in studies were fed Teklad 38977 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 106.9 mmol/l 0.81 2.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39107 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 8.91 x 10E6 cells/ul 0.21 0.66 automated blood cell counting method Moms and pups used in studies were fed Teklad 39227 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 143.8 mmol/l 1.02 3.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39378 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42876 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 10 21.3 mmol/l 0.4 1.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42975 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 116.96 % 8.97 31.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54397 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 10 4.27 x 1000 cells/ul 0.29 0.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 39878 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 10 24.8 mmol/l 0.39 1.23 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43116 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 14 0.72 x 1000 cells/ul 0.1 0.37 automated blood cell counting method Moms and pups used in studies were fed Teklad 43210 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 190.41 % 6.14 28.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54493 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 14.29 g/dl 0.14 0.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 40095 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 8 1.15 mg/kg 0.26 0.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58896 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 10 0.13 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 40287 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 176.4 g 3.1 10.0 whole body digital scale Moms and pups used in studies were fed Teklad 59052 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 10 3.82 g/dl 0.06 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40392 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 2.16 g/dl 0.04 0.13 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40540 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 13 51.62 U/l 2.03 7.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40700 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 8.65 mg/dl 0.39 1.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37584 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 14 19.93 mg/dl 0.68 2.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40814 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.18 g/kg 0.04 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59643 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.41 null 0.04 0.1 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59758 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 10 93.0 mg/dl 4.28 13.55 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38418 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 14 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41854 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41858 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 131.2 mmHg 4.31 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48614 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 11.16 ml/min/kg 0.64 1.93 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57588 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 27.14 ml/min 1.8 7.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16137 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 18 10.22 mmHg 2.07 8.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16273 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 21 0.62 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16459 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.2 null 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57894 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 22.47 ml/min/kg 1.67 4.72 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57985 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.88 degrees C 0.19 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 16562 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -6.97 null 0.12 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55609 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 0.03 10E-7mol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55739 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.47 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58099 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 1.53 E-7mole 0.3 1.12 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55870 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 268.4 g 6.0 18.8 whole body digital scale Moms and pups used in studies were fed Teklad 58323 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.07 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54890 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 34.0 % 3.98 14.88 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56273 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 98.67 % 1.2 4.64 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56310 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 32.31 % 4.06 14.65 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55133 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 16 99.44 % 0.44 1.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56464 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 99.57 % 0.31 1.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56469 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.11 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59873 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 9.64 ml/min/kg 0.65 1.82 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59987 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 -7.15 null 0.1 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56899 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 44.67 % 2.54 7.63 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57172 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 6 11.83 IU/g 0.85 2.09 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45703 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 15 175.9 g 2.7 10.5 whole body digital scale Moms and pups used in studies were fed Teklad 47797 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 79.31 % 8.13 28.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44908 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 84.82 % 6.41 23.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44904 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 15 post-ischemic value/pre-ischemic value x 100% 54.99 % 5.6 21.67 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46056 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 90.27 % 16.16 60.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48281 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 35.99 % 3.97 14.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46305 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 58.34 mmHg 6.63 22.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46403 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 12 0.23 IU/g 0.06 0.19 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47424 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 87.44 % 3.26 12.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48392 461