Phenominer Database Results (403 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 5BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 123.94 mmHg 2.73 3.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15090 381
SS-Chr 5BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 1.96 ml/min 0.13 0.33 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52154 482
SS-Chr 5BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 46.14 mg/d 7.31 23.12 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52695 482
SS-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 11.82 mg/d 2.27 6.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52593 482
SS-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 27.89 mg/d 5.0 15.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52595 482
SS-Chr 5BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 73.65 ml/min 3.16 9.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20759 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.01 % 9.49 28.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53881 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.11 % 6.89 21.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53979 381
SS-Chr 5BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 152.5 % 10.61 31.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54212 381
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 234.87 % 11.48 34.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14196 381
SS-Chr 5BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 179.83 breaths/min 7.46 22.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16906 381
SS-Chr 5BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.48 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20621 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 155.27 breaths/min 13.8 43.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18260 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 130.2 breaths/min 13.87 41.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18263 381
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 66.4 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20473 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -30.72 mmHg 4.68 6.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19456 381
SS-Chr 5BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 0.79 g 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49055 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1056.33 s 32.23 96.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50222 461
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 176.0 g 3.0 9.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49525 461
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 259.19 % 13.09 39.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19209 381
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 63.14 U/l 5.47 14.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42428 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 84.0 U/l 5.39 14.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42768 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.5 mmol/l 1.05 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39383 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 142.0 mmol/l 1.36 3.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39386 401
SS-Chr 5BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 7.74 x 1000 cells/ul 0.25 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39901 401
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.57 x 1000 cells/ul 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43219 401
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.84 x 1000 cells/ul 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43222 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.83 g/dl 0.15 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39772 401
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.33 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39672 401
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 0.97 mg/kg 0.16 0.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59180 526
SS-Chr 5BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 4.07 g/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40418 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 7.33 x 1000 cells/ul 0.55 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40924 401
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.27 g/dl 0.21 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37963 401
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 17.76 g/dl 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37966 401
SS-Chr 5BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41420 401
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.42 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59788 526
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 19.0 mmol/l 0.65 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38259 401
SS-Chr 5BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 6.88 x 10E6 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41980 401
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 89.43 mmHg 5.99 17.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45499 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1155.44 s 37.06 111.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46543 461
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 21.14 ml/min/kg 0.92 2.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57798 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 55.93 ml/min/kg 6.51 19.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57994 526
SS-Chr 5BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 36.6 ml/min 3.75 11.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16688 381
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.78 null 0.1 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55632 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.98 E-7mole 0.17 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55896 522
SS-Chr 5BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.62 g/mg 0.12 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55795 522
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.05 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54913 522
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59904 526
SS-Chr 5BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 11 188.4 g 5.7 18.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55184 522
SS-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 7.6 ml/min/g 0.55 1.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46868 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 83.88 mmHg 5.96 17.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46745 461
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 106.0 % 9.34 28.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44913 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 68.83 % 4.65 13.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46061 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 81.76 % 4.45 10.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48293 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 83.49 % 5.28 15.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48401 461
SS-Chr 5BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.26 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17977 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 8 122.04 mmHg 2.16 6.11 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52842 482
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.17 g/dl 0.28 0.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37339 401
SS-Chr 5BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 8 56.03 mg/d 10.37 29.33 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52693 482
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 64.7 mmHg 2.72 7.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46415 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 4.74 ml/min/g 0.44 1.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46199 461
SS-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.33 mg/dl 0.04 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39574 401
SS-Chr 5BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 5.21 x 1000 cells/ul 0.27 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39896 401
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -7.35 null 0.08 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56112 522
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41863 401
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 901.44 s 53.38 160.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50114 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 96.51 mmHg 5.2 14.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48622 461
SS-Chr 5BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.63 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41043 401
SS-Chr 5BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 273.4 g 8.3 26.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55422 522
SS-Chr 5BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 40.74 % 0.38 1.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41313 401
SS-Chr 5BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 40.58 % 0.55 1.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41318 401
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15228 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 118.96 breaths/min 6.82 20.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14792 381
SS-Chr 5BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 165.9 % 9.49 28.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54081 381
SS-Chr 5BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 8 1.03 mEq/d 0.09 0.27 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52940 482
SS-Chr 5BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.33 mEq/d 0.09 0.28 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52942 482
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 103.61 mmHg 24.88 35.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14328 381
SS-Chr 5BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.57 g/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37209 401
SS-Chr 5BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.28 degrees C 0.29 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19064 381
SS-Chr 5BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.01 degrees C 0.16 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19067 381
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 118.75 % 5.95 17.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18541 381
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.64 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36619 401
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 -34.8 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19461 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.13 degrees C 0.41 1.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20304 381
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.56 mmHg 0.39 1.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49172 461
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 282.74 % 21.95 65.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19206 381
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 4.05 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42228 401
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.64 g/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42231 401
SS-Chr 5BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 0.53 x 1000 cells/ul 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38907 401
SS-Chr 5BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.57 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38912 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 68.5 U/l 3.16 8.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42765 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.54 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39232 401
SS-Chr 5BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 17.57 mmol/l 0.72 1.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43142 401
SS-Chr 5BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.75 mmol/l 0.67 1.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43147 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 31.76 g/dl 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39775 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.2 pg 0.09 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40214 401
SS-Chr 5BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 158.92 % 11.9 35.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53627 381
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 169.5 g 4.2 13.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59057 526
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 54.24 % 0.54 1.53 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59252 526
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 55.91 % 0.38 0.99 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59255 526
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.52 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59652 526
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.12 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59542 526
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 47.14 U/l 1.88 4.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37718 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.89 x 1000 cells/ul 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40921 401
SS-Chr 5BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 84.0 mg/dl 1.94 5.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38449 401
SS-Chr 5BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 7.15 x 10E6 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41985 401
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 27.52 ml/min/kg 1.56 4.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57795 526
SS-Chr 5BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 40.74 % 0.38 1.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57498 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 48.26 ml/min/kg 2.58 7.74 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58242 526
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 87.91 % 3.41 11.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54782 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 88.13 % 6.08 17.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54787 522
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.04 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54676 522
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 26.44 ml/min/kg 2.24 6.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58634 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 20.32 ml/min/kg 1.43 4.28 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58639 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 14.63 ml/min/kg 0.94 2.66 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60005 526
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 91.8 % 2.85 9.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57226 522
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 33.2 mmHg 0.2 0.28 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16065 381
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 33.9 mmHg 3.62 10.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47909 461
SS-Chr 5BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 9 152.9 g 2.7 8.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47815 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.47 ml/min/g 0.63 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44713 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.85 ml/min/g 0.63 1.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44716 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.41 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47453 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 23.28 mmHg 4.42 12.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45268 461
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 130.42 mmHg 2.59 6.85 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52844 482
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.83 % 5.76 17.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46314 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 81.61 % 3.41 10.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48404 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 34.39 mmHg 3.29 9.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45265 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 52.84 mmHg 4.39 13.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47699 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 90.93 mmHg 3.55 10.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44810 461
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 839.88 s 32.23 91.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49297 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 15.95 % 2.87 8.62 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49391 461
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41866 401
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 82.0 mmHg 5.55 17.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45502 461
SS-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 1.77 g/dl 0.02 0.05 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40548 401
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.23 0.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59176 526
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 253.0 beats/min 10.05 30.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47577 461
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.39 null 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55282 522
SS-Chr 5BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 116.47 breaths/min 6.62 19.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14930 381
SS-Chr 5BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 2 98.28 mmHg 4.6 6.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13478 381
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 0.02 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19782 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 115.2 % 8.47 25.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53749 381
SS-Chr 5BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 394.19 beats/min 29.59 59.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20914 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.55 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17041 381
SS-Chr 5BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 130.67 mmHg 13.02 26.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15085 381
SS-Chr 5BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 8 16.93 mEq/d 1.84 5.21 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52744 482
SS-Chr 5BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 20.67 mEq/d 1.77 5.6 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52746 482
SS-Chr 5BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 6 2.69 ml/min 0.11 0.28 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52156 482
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 26.1 mmHg 0.5 0.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17238 381
SS-Chr 5BN/Mcwi percentage of study population developing mammary tumors during a period of time 7,12-dimethyltetraphene (DMBA) (65 g/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152 days-162 days 13 54.0 % manual palpation method 0 DMBA oral gavage 105 days 200 mg DMBA in 10 ml seame oil 11493 86
SS-Chr 5BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 173.3 breaths/min 8.04 24.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17106 381
SS-Chr 5BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 168.12 breaths/min 4.4 13.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16909 381
SS-Chr 5BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17980 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.58 degrees C 0.18 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20307 381
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 60.43 mmHg 5.98 8.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20468 381
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 158.7 g 4.5 14.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49520 461
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 54.24 % 0.54 1.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38986 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 92.14 U/l 10.97 29.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42433 401
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 105.13 mmol/l 0.74 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39112 401
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 106.86 mmol/l 1.16 3.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39115 401
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 63.58 fl 0.4 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38740 401
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 125.58 % 14.01 42.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54322 381
SS-Chr 5BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 161.27 % 8.52 25.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54421 381
SS-Chr 5BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.65 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40423 401
SS-Chr 5BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 3.61 mmol/l 0.06 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43338 401
SS-Chr 5BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 103.43 mmol/l 0.87 2.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40017 401
SS-Chr 5BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 13.01 g/dl 0.16 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40118 401
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 10.1 mg/dl 0.33 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37592 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 22.75 mg/dl 1.18 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40823 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 7 21.43 mg/dl 1.25 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40826 401
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.96 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59470 526
SS-Chr 5BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.75 mg/dl 0.39 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37843 401
SS-Chr 5BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 8.4 mg/dl 0.28 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37838 401
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.6 mmol/l 0.22 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38064 401
SS-Chr 5BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.04 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41415 401
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 152.57 mg/dl 5.16 13.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38528 401
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.91 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45403 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 266.65 beats/min 6.08 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47580 461
SS-Chr 5BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 59.23 fl 0.18 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38658 401
SS-Chr 5BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 56.76 fl 0.25 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38663 401
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 94.83 % 4.7 14.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48751 461
SS-Chr 5BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 27.5 ml/min 3.15 9.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16685 381
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.27 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57917 526
SS-Chr 5BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 172.1 g 3.6 11.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58349 526
SS-Chr 5BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 223.7 g 8.1 25.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58354 526
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.53 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58108 526
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.06 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54681 522
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.87 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56922 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 86.38 % 8.85 25.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57231 522
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 35.0 mmHg 1.4 1.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16061 381
SS-Chr 5BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 34.3 mmHg 4.12 13.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48031 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 47.71 % 4.02 11.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47075 461
SS-Chr 5BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 259.59 beats/min 7.36 22.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48192 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 187.87 beats/min 11.71 35.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45143 461
SS-Chr 5BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 105.76 breaths/min 6.41 19.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18408 381
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 178.5 U/l 6.51 18.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36374 401
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 39.65 % 4.17 12.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47072 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.28 mmHg 0.39 1.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47192 461
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.04 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19777 381
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 222.21 beats/min 12.58 30.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45146 461
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 45.62 % 4.9 14.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46317 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.2 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47449 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.15 IU/g 0.04 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47309 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 101.37 mmHg 6.0 18.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45724 461
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.69 g/kg 0.26 0.81 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45618 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 23.95 IU/g 2.61 7.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45969 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.26 ml/min/g 0.72 2.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46865 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 86.74 mmHg 6.51 19.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44813 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 35.89 mmHg 2.47 7.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48028 461
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 144.38 mg/dl 2.77 7.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38525 401
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.9 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45400 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1062.6 s 17.25 54.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46546 461
SS-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.66 g/dl 0.05 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40545 401
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.52 E-7mole 0.22 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56527 522
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 21.25 IU/g 2.13 6.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48864 461
SS-Chr 5BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.5 g/dl 0.02 0.06 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41038 401
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 11.57 ml/min/kg 1.07 3.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60010 526
SS-Chr 5BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 149.86 mg/dl 3.58 9.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41205 401
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59545 526
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.27 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57912 526
SS-Chr 5BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 109.45 breaths/min 9.07 27.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14933 381
SS-Chr 5BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 148.16 % 9.1 27.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54215 381
SS-Chr 5BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 178.0 % 11.35 34.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54078 381
SS-Chr 5BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 156.82 breaths/min 6.07 18.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17109 381
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 162.77 % 10.09 31.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13675 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.38 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13921 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 105.46 % 5.47 16.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53982 381
SS-Chr 5BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 76.17 ml/min 3.37 10.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20756 381
SS-Chr 5BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 2 107.29 mmHg 7.28 10.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19859 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 118.23 % 8.27 26.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53746 381
SS-Chr 5BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 107.7 breaths/min 8.94 28.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18405 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.5 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17046 381
SS-Chr 5BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 4.47 x 1000 cells/ul 0.25 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36880 401
SS-Chr 5BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 6.77 x 1000 cells/ul 0.32 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36885 401
SS-Chr 5BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 91.15 mmHg 10.65 15.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18860 381
SS-Chr 5BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 2 413.38 beats/min 35.54 50.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14691 381
SS-Chr 5BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15392 381
SS-Chr 5BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.3 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15395 381
SS-Chr 5BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 83.52 ml/min 4.18 12.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14495 381
SS-Chr 5BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.29 degrees C 0.24 0.72 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15664 381
SS-Chr 5BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.06 degrees C 0.31 0.94 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15667 381
SS-Chr 5BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 7 368.73 beats/min 6.96 18.42 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52646 482
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 261.02 % 24.25 72.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14193 381
SS-Chr 5BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.57 degrees C 0.31 0.92 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13554 381
SS-Chr 5BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.96 degrees C 0.2 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13557 381
SS-Chr 5BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 9 250.2 g 5.1 15.4 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17815 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 43.46 ml/min 3.61 11.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18657 381
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.08 g/dl 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37344 401
SS-Chr 5BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.76 mg/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36770 401
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 403.95 beats/min 35.32 70.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17496 381
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 369.86 beats/min 16.67 23.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17501 381
SS-Chr 5BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.92 g 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49058 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 16.26 % 3.05 9.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49693 461
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 55.91 % 0.38 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38989 401
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 62.46 fl 0.47 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38743 401
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 20.71 mmol/l 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42060 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 8.95 x 10E6 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39235 401
SS-Chr 5BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 159.83 % 10.41 31.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53630 381
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.15 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39669 401
SS-Chr 5BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 103.88 mmol/l 0.69 1.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40022 401
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 218.1 g 7.1 22.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59060 526
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.41 mg/dl 0.51 1.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37589 401
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.17 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59465 526
SS-Chr 5BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 146.25 mg/dl 3.12 8.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41210 401
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 3.99 mmol/l 0.14 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38061 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 79.5 U/l 9.07 25.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37723 401
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.28 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59655 526
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.14 x 1000 cells/ul 0.29 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41498 401
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 6.16 x 1000 cells/ul 0.44 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41501 401
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.88 mmol/l 0.61 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38256 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41642 401
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.4 null 0.04 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59784 526
SS-Chr 5BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 20.13 mg/dl 1.19 3.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41768 401
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 96.09 mmHg 5.9 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48619 461
SS-Chr 5BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 8 270.5 g 8.3 23.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55188 522
SS-Chr 5BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 30.48 ml/min 1.84 5.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16142 381
SS-Chr 5BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 31.62 ml/min 1.35 4.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16145 381
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 18.26 ml/min/kg 0.72 2.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57593 526
SS-Chr 5BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 216.31 beats/min 13.5 40.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48940 461
SS-Chr 5BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.8 g/mg 0.1 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57341 522
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 43.81 ml/min/kg 2.49 7.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57997 526
SS-Chr 5BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 182.6 g 3.2 10.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55418 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.93 E-7mole 0.35 0.98 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55901 522
SS-Chr 5BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.93 degrees C 0.15 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16807 381
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58487 526
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54908 522
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.59 mg/kg 0.55 1.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58901 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.06 mg/kg 0.12 0.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58904 526
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 -6.88 null 0.03 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56917 522
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 55.38 mmHg 1.62 4.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47696 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 100.91 mmHg 5.01 14.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45727 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.16 ml/min/g 0.6 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46651 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 4.4 mmHg 0.33 0.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47195 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 74.5 % 4.01 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48290 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.47 mmHg 0.37 1.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49175 461
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 115.86 % 10.91 34.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53878 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15231 381
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 26.73 mmHg 1.43 2.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17234 381
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 131.74 % 9.32 27.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13678 381
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 5.41 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36960 401
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 311.25 U/l 17.05 48.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37466 401
SS-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.3 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52205 482
SS-Chr 5BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 243.56 beats/min 12.94 40.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48195 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.29 IU/g 0.06 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47315 461
SS-Chr 5BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 5.2 g/kg 0.16 0.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46993 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 63.91 % 3.95 11.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46064 461
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -7.06 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55627 522
SS-Chr 5BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.9 g/mg 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55790 522
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.81 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56107 522
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 20.24 % 3.13 8.28 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49696 461
SS-Chr 5BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.17 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40305 401
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 87.98 mmHg 4.28 12.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49886 461
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58731 526
SS-Chr 5BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 40.58 % 0.55 1.54 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57503 526
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 1.34 E-7mole 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56522 522
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 22.32 % 4.85 13.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48525 461
SS-Chr 5BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 7 0.27 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42657 401
SS-Chr 5BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 81.03 ml/min 2.8 8.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14498 381
SS-Chr 5BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 2 447.59 beats/min 66.24 93.67 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15921 381
SS-Chr 5BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 8 396.82 beats/min 6.28 17.76 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52644 482
SS-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.3 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52203 482
SS-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 0.44 ng/ml/h 0.08 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52448 482
SS-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 6 0.68 ng/ml/h 0.33 0.8 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52450 482
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13918 381
SS-Chr 5BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 426.62 beats/min 36.15 51.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20919 381
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.71 g/dl 0.07 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36957 401
SS-Chr 5BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 101.2 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18865 381
SS-Chr 5BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.28 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37214 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 68.0 mg/dl 2.49 7.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37092 401
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 122.56 breaths/min 6.84 21.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14789 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 124.62 mmHg 13.43 26.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14323 381
SS-Chr 5BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 177.4 g 7.1 22.4 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17812 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -7.1 mmHg 0.7 0.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19630 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 46.63 ml/min 3.67 11.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18660 381
SS-Chr 5BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 121.81 % 8.46 26.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18538 381
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 152.57 U/l 7.2 19.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37461 401
SS-Chr 5BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 143.29 mmol/l 0.68 1.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36501 401
SS-Chr 5BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 144.13 mmol/l 1.03 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36506 401
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.54 mg/dl 0.08 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36622 401
SS-Chr 5BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.56 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36775 401
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 31.66 ml/min 1.84 5.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20203 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 41.93 ml/min 2.51 7.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20206 381
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 824.78 s 43.86 131.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49294 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 22.78 % 4.29 13.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49394 461
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 879.4 s 15.19 48.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50117 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1037.38 s 26.13 73.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50225 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 94.24 mmHg 2.77 8.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49883 461
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 22.38 mmol/l 0.73 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42057 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.24 pg 0.09 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42540 401
SS-Chr 5BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.26 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42662 401
SS-Chr 5BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 169.29 % 11.67 35.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54418 381
SS-Chr 5BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 26.38 mmol/l 0.42 1.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43006 401
SS-Chr 5BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42899 401
SS-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.38 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39571 401
SS-Chr 5BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.4 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40310 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 19.06 pg 0.18 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40209 401
SS-Chr 5BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 3.85 mmol/l 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43343 401
SS-Chr 5BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 13.1 g/dl 0.07 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40113 401
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 149.73 % 14.83 46.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54319 381
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 47.38 U/l 3.78 10.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40709 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 61.43 U/l 4.58 12.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40712 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41645 401
SS-Chr 5BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 18.43 mg/dl 0.72 1.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41763 401
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 37.36 % 4.24 12.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48522 461
SS-Chr 5BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 196.75 beats/min 11.51 34.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48943 461
SS-Chr 5BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 1.11 g/mg 0.14 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57336 522
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 14.63 ml/min/kg 0.62 1.75 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57596 526
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 85.95 % 4.33 12.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48754 461
SS-Chr 5BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.47 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16468 381
SS-Chr 5BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.49 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16471 381
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.06 degrees C 0.41 1.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16567 381
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.27 degrees C 0.25 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16570 381
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.5 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58111 526
SS-Chr 5BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.69 degrees C 0.18 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16810 381
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58484 526
SS-Chr 5BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.44 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17365 381
SS-Chr 5BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.47 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17368 381
SS-Chr 5BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.1 g/kg 0.29 0.92 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46998 461
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.18 g/kg 0.19 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45623 461
SS-Chr 5BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 182.1 g 10.4 32.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47820 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.62 ml/min/g 0.6 1.81 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46196 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 59.85 mmHg 4.35 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46412 461
SS-Chr 5BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.5 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20616 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -8.27 mmHg 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19626 381
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 286.86 U/l 9.86 26.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36377 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 73.71 mg/dl 4.38 11.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37095 401
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.02 ml/min/g 0.65 1.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46648 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 76.53 mmHg 5.58 17.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46748 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 30.89 IU/g 3.64 10.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45971 461
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 107.47 % 7.71 23.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44916 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 35.55 mmHg 2.77 8.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47906 461
SS-Chr 5BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42894 401
SS-Chr 5BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 78.57 mg/dl 1.49 3.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38444 401
SS-Chr 5BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 26.14 mmol/l 0.59 1.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43001 401
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 62.12 ml/min/kg 4.56 12.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58238 526
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 40.22 mmHg 4.9 14.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49992 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 36.13 mmHg 2.72 7.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49995 461
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.44 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58728 526
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.09 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59899 526
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 21.9 IU/g 2.48 7.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48860 461
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59369 526
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59374 526
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.52 null 0.13 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55277 522
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 19.86 pg 0.15 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42543 401