| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
124.0 |
um |
4.2 |
9.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105481 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
126.0 |
um |
4.02 |
9.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105486 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
123.8 |
um |
4.83 |
10.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105502 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
125.4 |
um |
3.53 |
7.9 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105472 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
122.4 |
um |
4.65 |
10.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105489 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
129.9 |
um |
3.71 |
8.3 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105471 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
131.6 |
um |
4.87 |
10.9 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105470 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
129.6 |
um |
4.2 |
9.4 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105473 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
128.7 |
um |
4.92 |
11.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105478 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
120.4 |
um |
4.25 |
9.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105505 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
128.6 |
um |
4.11 |
9.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105480 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
121.9 |
um |
4.38 |
9.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105494 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
122.6 |
um |
4.74 |
10.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105504 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
126.1 |
um |
4.11 |
9.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105495 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
120.7 |
um |
4.2 |
9.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105496 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
125.1 |
um |
3.98 |
8.9 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105487 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
124.7 |
um |
3.89 |
8.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105488 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
120.9 |
um |
5.19 |
11.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105497 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
125.7 |
um |
3.89 |
8.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105503 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
127.2 |
um |
3.85 |
8.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105479 |
3016 |