| RCS-p+/LavRrrc |
retinal inner nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
51.0 days
| 5 |
26.3 |
um |
1.5 |
3.35 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
pVAX2-rGDNF |
retinal inner nuclear layer thickness (CMO:0003668) |
108707 |
3131 |
| RCS-p+/LavRrrc |
retinal inner nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
51.0 days
| 5 |
19.6 |
um |
0.5 |
1.12 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
|
retinal inner nuclear layer thickness (CMO:0003668) |
108708 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
51.0 days
| 5 |
8.1 |
um |
0.4 |
0.89 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
pVAX2-rGDNF |
superior hemisphere - photoreceptor IS |
108711 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
70.0 days
| 4 |
8.3 |
um |
1.7 |
3.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108744 |
3131 |
| RCS-p+/LavRrrc |
retinal inner nuclear layer thickness |
control condition |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
75.0 days
| 3 |
25.1 |
um |
1.3 |
2.25 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
55 |
days |
control for age matched plasmid injection |
|
108698 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
75.0 days
| 5 |
14.4 |
um |
1.5 |
3.35 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
55 |
days |
|
|
108699 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
51.0 days
| 5 |
6.4 |
um |
0.3 |
0.67 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
|
superior hemisphere - photoreceptor IS |
108712 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 5 |
8.5 |
um |
0.7 |
1.57 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108718 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
70.0 days
| 4 |
32.2 |
um |
1.6 |
3.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108738 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
70.0 days
| 4 |
9.2 |
um |
1.0 |
2.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108743 |
3131 |
| RCS-p+/LavRrrc |
retinal inner nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
75.0 days
| 5 |
29.9 |
um |
1.5 |
3.35 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
55 |
days |
|
|
108697 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
51.0 days
| 5 |
27.7 |
um |
1.1 |
2.46 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
pVAX2-rGDNF |
superior hemisphere |
108709 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
70.0 days
| 5 |
0.9 |
um |
0.2 |
0.45 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere - photoreceptor IS |
108716 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
70.0 days
| 5 |
1.8 |
um |
0.4 |
0.89 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere - photoreceptor IS |
108715 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
87.0 days
| 5 |
1.5 |
um |
0.4 |
0.89 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
pVAX2-rGDNF |
superior hemisphere - photoreceptor IS |
108723 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
87.0 days
| 5 |
4.7 |
um |
0.7 |
1.57 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
|
superior hemisphere |
108722 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
17.6 |
um |
1.7 |
3.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108740 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
70.0 days
| 5 |
20.1 |
um |
0.6 |
1.34 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108714 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
87.0 days
| 5 |
5.4 |
um |
0.6 |
1.34 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
pVAX2-rGDNF |
superior hemisphere |
108721 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
87.0 days
| 5 |
1.1 |
um |
0.5 |
1.12 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
|
superior hemisphere - photoreceptor IS |
108724 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
70.0 days
| 4 |
30.5 |
um |
1.3 |
2.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108737 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
16.8 |
um |
1.9 |
3.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108741 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
control condition |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
75.0 days
| 3 |
8.1 |
um |
1.2 |
2.08 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
55 |
days |
control for age matched plasmid injection |
|
108700 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
51.0 days
| 5 |
22.2 |
um |
0.9 |
2.01 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
35 |
days |
|
superior hemisphere |
108710 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
70.0 days
| 5 |
27.4 |
um |
0.6 |
1.34 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108713 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
87.0 days
| 5 |
20.8 |
um |
0.9 |
2.01 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
|
superior hemisphere |
108720 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 5 |
9.4 |
um |
1.0 |
2.24 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108717 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
87.0 days
| 5 |
21.4 |
um |
0.7 |
1.57 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
71 |
days |
pVAX2-rGDNF |
superior hemisphere |
108719 |
3131 |
| RCS-p+/LavRrrc |
retinal inner layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal inner nuclear layer morphology trait |
both |
70.0 days
| 4 |
28.3 |
um |
1.3 |
2.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108739 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
10.6 |
um |
1.7 |
3.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108742 |
3131 |
| RCS-p+/LavRrrc |
photoreceptor inner segment thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
photoreceptor inner segment morphology trait |
both |
70.0 days
| 4 |
5.2 |
um |
1.2 |
2.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108745 |
3131 |