Phenominer Database Results (864 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 98.01 mmHg 4.51 12.76 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15053 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 7.78 mmHg 2.59 6.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15183 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 32.39 mmHg 5.47 10.95 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15545 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 -10.52 mmHg 0.32 0.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15646 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 -7.27 mmHg 2.53 3.57 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15653 381
SHR/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 0.13 degrees C 0.23 1.04 digital rectal thermometry Moms and pups used in studies were fed Teklad 15663 381
SHR/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 479.96 beats/min 14.71 36.03 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15339 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 -0.04 null 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15351 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14611 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 129.72 mmHg 6.02 14.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14664 381
SHR/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 397.36 beats/min 9.06 25.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14690 381
SHR/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 -0.28 degrees C 0.28 0.97 digital rectal thermometry Moms and pups used in studies were fed Teklad 16016 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 0.35 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15227 381
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -88.0 beats/min 18.35 55.05 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51712 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 9 24.02 mg/d 3.75 11.24 automated urine analysis Moms and pups used in studies were fed Teklad 51755 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 10 19.39 mg/d 3.77 11.91 automated urine analysis Moms and pups used in studies were fed Teklad 51758 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 5 0.97 ml/min 0.1 0.22 urine creatinine analysis Moms and pups used in studies were fed Dyets 51800 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 127.98 mmHg 2.2 6.22 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51825 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 6 1.23 ng/ml/h 0.27 0.66 radioimmunoassay Moms and pups used in studies were fed Teklad 51838 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -8.33 beats/min 29.02 82.09 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51856 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -16.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51922 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 10.76 mEq/d 0.53 1.6 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52019 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 423.68 beats/min 13.94 39.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50531 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -30.8 beats/min 7.68 18.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50591 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 3.22 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50604 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 -25.11 mmHg 3.07 8.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50631 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -15.3 mmHg 6.88 16.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50809 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 2.79 mmHg 5.37 13.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50922 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.89 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50931 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 11.69 mmHg 6.31 15.46 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50934 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 137.12 mmHg 4.62 13.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50947 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 5 6.62 ng/ml/h 1.19 2.66 radioimmunoassay Moms and pups used in studies were fed Teklad 51008 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 0.83 ml/min 0.17 0.38 urine creatinine analysis Moms and pups used in studies were fed Teklad 51057 481
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 161.28 % 8.58 33.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54205 381
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -2.86 beats/min 5.12 13.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51095 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.51 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51131 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.32 mg/dl 0.01 0.01 radioimmunoassay Moms and pups used in studies were fed Dyets 51181 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 31.18 mmHg 4.47 13.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51192 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 355.95 beats/min 5.94 15.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51252 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 24.08 mmHg 4.27 12.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51341 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 2.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51372 481
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 184.8 % 10.55 40.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54071 381
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -16.02 beats/min 14.65 43.95 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51508 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -42.14 beats/min 19.17 54.23 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51511 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 1.08 mEq/d 0.16 0.45 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51521 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 328.06 beats/min 5.66 16.02 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51582 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.26 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51652 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 31.47 beats/min 18.3 44.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50511 481
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 0.01 null 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14772 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 31.37 mmHg 1.54 4.34 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13437 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.28 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13647 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 78.77 ml/min 8.28 24.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14164 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 93.62 ml/min 3.72 11.78 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14171 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 96.95 mmHg 2.47 6.52 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17303 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 91.79 mmHg 2.54 5.08 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17310 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.47 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17347 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.97 % 9.67 29.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14034 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 547.29 beats/min 12.81 31.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14066 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 34.92 ml/min 3.87 11.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20702 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 45.35 ml/min 2.66 8.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20709 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 3.77 mmHg 4.08 12.91 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20739 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 103.06 ml/min 5.29 23.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20755 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 15.87 mmHg 2.04 5.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20877 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 418.51 beats/min 7.41 28.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20918 381
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 177.71 % 8.07 25.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53847 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 98.36 % 5.58 23.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53972 381
SHR/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 145.43 mmHg 5.96 16.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20057 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 -4.77 mmHg 4.04 6.99 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20595 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 164.6 breaths/min 6.6 20.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20684 381
SHR/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 102.87 mmHg 3.68 8.23 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19536 381
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.88 degrees C 0.22 0.69 digital rectal thermometry Moms and pups used in studies were fed Dyets 17577 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.53 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17608 381
SHR/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 8 39.04 degrees C 0.12 0.34 digital rectal thermometry Moms and pups used in studies were fed Teklad 17651 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 146.51 breaths/min 8.7 26.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17686 381
SHR/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 12 418.75 beats/min 9.1 31.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17753 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 160.48 mmHg 8.36 22.11 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17771 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 134.77 mmHg 10.16 32.12 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17775 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 101.28 breaths/min 6.1 19.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17801 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 -54.34 mmHg 3.56 8.72 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17938 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 41.32 ml/min 4.91 14.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18070 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 7.55 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17045 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 112.64 breaths/min 5.96 26.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18404 381
SHR/NCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 144.7 U/l 5.35 16.91 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37055 401
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 23.22 mmHg 0.78 1.35 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19027 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during7-9 min hypercapnia/control during standard conditions 142.08 % 8.64 36.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18540 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.29 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18631 381
SHR/NCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 11 9.65 mg/dl 0.12 0.4 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36607 401
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 125.34 mmHg 3.44 9.11 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19517 381
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 33.62 ml/min 2.25 7.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18192 381
SHR/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 464.41 beats/min 10.76 28.46 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18197 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.26 degrees C 0.12 0.37 digital rectal thermometry Moms and pups used in studies were fed Dyets 18232 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 27.28 mmHg 1.31 3.2 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20413 381
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 119.97 beats/min 25.76 51.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20432 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20548 381
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 65.35 mmHg 13.22 37.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49617 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 6.43 IU/g 0.52 1.47 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49843 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 63.0 mmHg 3.24 10.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49991 461
SHR/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 727.1 s 78.55 235.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50113 461
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 1059.06 s 51.85 207.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50224 461
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 88.14 beats/min 15.56 34.79 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19168 381
SHR/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 4 37.25 degrees C 0.21 0.41 digital rectal thermometry Moms and pups used in studies were fed Dyets 19195 381
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 15 52.17 fl 0.2 0.78 automated blood cell counting method Moms and pups used in studies were fed Teklad 38742 401
SHR/NCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 11 235.09 U/l 20.98 69.59 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42155 401
SHR/NCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 11 4.59 mmol/l 0.11 0.36 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42167 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 11.18 x 10E6 cells/ul 0.15 0.63 automated blood cell counting method Moms and pups used in studies were fed Teklad 39231 401
SHR/NCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 18.5 mmol/l 1.12 3.54 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42512 401
SHR/NCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 11 1.01 x 1000 cells/ul 0.09 0.29 automated blood cell counting method Moms and pups used in studies were fed Dyets 39367 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 20 141.75 mmol/l 0.58 2.57 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39382 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 17 142.41 mmol/l 0.55 2.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39385 401
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 17 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39573 401
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 187.43 % 8.19 35.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54413 381
SHR/NCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 11 0.36 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 43098 401
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 15 0.8 x 1000 cells/ul 0.14 0.55 automated blood cell counting method Moms and pups used in studies were fed Teklad 43221 401
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 85.37 % 3.54 10.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54547 381
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.08 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 58871 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 15 1.68 mg/kg 0.23 0.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58900 526
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 163.07 % 10.91 42.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53620 381
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 20 2.1 g/dl 0.03 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40544 401
SHR/NCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 44.27 % 0.77 2.45 automated blood cell counting method Moms and pups used in studies were fed Dyets 40681 401
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 20 22.5 mg/dl 0.67 2.98 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40822 401
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 17 23.29 mg/dl 0.83 3.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40825 401
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 19 0.12 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59544 526
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 17.69 g/dl 0.27 1.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 37965 401
SHR/NCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 11 51.72 fl 0.25 0.84 automated blood cell counting method Moms and pups used in studies were fed Dyets 38212 401
SHR/NCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 11 2.21 g/dl 0.06 0.21 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41596 401
SHR/NCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 17.04 pg 0.15 0.49 automated blood cell counting method Moms and pups used in studies were fed Dyets 38393 401
SHR/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 17 151.35 mg/dl 6.49 26.74 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38527 401
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 17 0.19 mg/dl 0.03 0.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41865 401
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 120.78 mmHg 5.7 15.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45498 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 75.69 % 11.37 40.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48753 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 212.27 beats/min 16.0 48.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48939 461
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.19 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57411 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 2 63.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55358 522
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 -7.27 null 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55371 522
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.19 null 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55374 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -8.58 null 0.14 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55487 522
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.45 null 0.17 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55722 522
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 24.0 mmHg 5.79 11.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16785 381
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55973 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 99.44 % 0.44 1.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56196 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 96.9 % 1.87 5.92 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56202 522
SHR/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.32 g/mg 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56217 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.28 10E-7mol/l 0.18 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56268 522
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 10 1.34 mg/kg 0.19 0.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58854 526
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 72.0 % 2.63 7.45 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55103 522
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 74.4 % 4.04 12.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55109 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 31.9 % 3.1 9.8 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56723 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.78 E-7mole 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57132 522
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.56 ml 0.03 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17367 381
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 9.67 ml/min/g 0.78 2.94 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46650 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 126.59 mmHg 7.68 21.72 balloon tipped catheter with pressure transducer in isolated perfused heart 46747 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 318.97 beats/min 28.2 89.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47679 461
SHR/NCrl body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 188.2 g 4.1 12.8 whole body digital scale Moms and pups used in studies were fed Teklad 47814 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 13 8.75 ml/min/g 1.4 5.05 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44715 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 136.39 mmHg 7.83 22.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45824 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 34.42 % 12.12 38.33 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45916 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 10.19 ml/min/g 0.83 2.33 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46867 461
SHR/NCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.01 g/kg 0.12 0.38 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 46992 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 57.97 % 12.35 39.06 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46063 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 6.57 ml/min/g 1.0 2.99 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46195 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 47.62 % 9.16 34.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47074 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 238.0 beats/min 14.96 44.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48191 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 236.37 beats/min 16.99 53.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48194 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 85.73 % 12.53 39.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48289 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 12 200.73 beats/min 27.04 93.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45145 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 42.24 mmHg 6.2 19.62 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45264 461
SHR/NCrl brain campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain campesterol amount not specified 77.0 days 2 0.02 mg/g unspecified method 0.0 tissue campesterol measurement test 70531 1300
SHR/NCrl liver cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver cholesterol amount not specified 77.0 days 2 1.85 mg/g unspecified method 0.0 tissue total cholesterol analysis 70166 1300
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 104.94 mmHg 3.4 11.27 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15057 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 15.62 mmHg 4.45 11.77 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15153 381
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 25.84 ml/min 1.96 5.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15615 381
SHR/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 409.29 beats/min 13.42 32.86 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15346 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 100.39 breaths/min 5.37 16.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14443 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 12 35.76 mmHg 0.93 3.21 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14478 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14607 381
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 181.69 % 6.61 20.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53531 381
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 10.79 beats/min 17.8 35.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51723 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -26.04 beats/min 15.48 46.44 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51726 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 31.28 mmHg 4.3 10.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51776 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 117.77 mmHg 2.86 7.56 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51828 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 7.96 mEq/d 0.5 1.4 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51887 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.28 beats/min 7.95 19.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51929 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 24.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51965 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -11.11 beats/min 8.75 26.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50618 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -23.04 mmHg 2.62 6.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50634 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 153.09 mmHg 2.46 6.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50645 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.23 beats/min 4.03 9.87 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50689 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 4.57 mmHg 2.78 8.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50703 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 173.36 mmHg 5.88 16.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50739 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 4.02 mmHg 8.2 20.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50783 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 357.13 beats/min 8.47 20.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50883 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 165.57 mmHg 8.37 16.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50944 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 29.71 mmHg 9.04 18.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50966 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 3.33 ng/ml/h 0.45 1.11 radioimmunoassay Moms and pups used in studies were fed Teklad 51011 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 145.23 mmHg 3.65 10.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51146 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -58.2 beats/min 16.54 49.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51226 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.73 beats/min 16.5 40.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51242 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 1.46 mEq/d 0.11 0.36 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51270 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -35.62 beats/min 11.0 33.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51357 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 10 0.47 mg/d 0.04 0.12 automated urine analysis Moms and pups used in studies were fed Teklad 51474 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.03 mEq/d 0.18 0.54 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51524 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -32.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50357 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 385.51 beats/min 15.45 46.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50479 481
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 heart rate during walking-heart rate during rest 50.91 beats/min 17.59 43.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13403 381
SHR/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 148.12 mmHg 9.3 30.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13482 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 154.15 breaths/min 5.16 19.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17108 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 6 28.66 mmHg 0.69 1.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17233 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 482.26 beats/min 17.1 41.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13806 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 510.35 beats/min 25.83 51.66 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14073 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 355.23 % 27.19 81.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14089 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20858 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 379.64 beats/min 16.59 46.91 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20913 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 152.74 % 5.48 24.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53741 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 108.39 mmHg 1.85 5.23 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19981 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 -5.78 mmHg 1.86 4.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20588 381
SHR/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 109.58 mmHg 1.98 4.84 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19529 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 33.72 mmHg 1.0 2.64 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19564 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 309.24 % 30.02 90.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19599 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 11 -8.56 mmHg 1.18 3.91 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19629 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 176.45 breaths/min 6.85 20.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17620 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 164.3 breaths/min 5.97 18.88 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17627 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 19 167.41 breaths/min 4.84 21.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16905 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.53 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17040 381
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 80.45 beats/min 20.55 54.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18360 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 102.61 breaths/min 6.72 28.5 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18407 381
SHR/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 92.07 mmHg 3.31 8.11 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18859 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 132.75 mmHg 9.71 30.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18954 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 7.39 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19015 381
SHR/NCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.2 mg/dl 0.01 0.05 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36275 401
SHR/NCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 32.77 g/dl 0.18 0.58 automated blood cell counting method Moms and pups used in studies were fed Dyets 36311 401
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 20 327.95 U/l 16.2 72.45 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36373 401
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 17 198.0 U/l 5.4 22.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36376 401
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 %change=VE during7-9 min hypercapnia/control during standard conditions 135.66 % 6.35 28.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18537 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.34 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18638 381
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 20 9.14 mg/dl 0.06 0.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36618 401
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 17 9.03 mg/dl 0.1 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36621 401
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 -0.93 degrees C 0.18 0.76 digital rectal thermometry Moms and pups used in studies were fed Teklad 20306 381
SHR/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 133.97 mmHg 5.35 11.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20404 381
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 84.02 beats/min 8.19 20.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20425 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 50.35 mmHg 1.64 4.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20467 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 -0.09 null 0.01 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20563 381
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 136.9 g 3.5 11.0 whole body digital scale Moms and pups used in studies were fed Teklad 49524 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 17.5 % 2.99 9.45 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49643 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 6.46 IU/g 0.89 2.68 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49839 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 100.08 mmHg 4.32 13.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49882 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 111.5 mmHg 4.44 16.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49885 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 320.85 beats/min 16.53 36.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 50312 461
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 231.55 beats/min 25.2 71.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 50317 461
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 %change=VE during 2-3 min hypercapnia/control during standard conditions 308.31 % 31.24 120.99 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19208 381
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 18 53.99 fl 0.35 1.5 automated blood cell counting method Moms and pups used in studies were fed Teklad 38739 401
SHR/NCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 177.2 U/l 15.79 49.94 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42149 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 60.33 % 0.72 3.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 38985 401
SHR/NCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 79.7 mg/dl 2.7 8.55 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39204 401
SHR/NCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 11 21.73 mmol/l 0.68 2.24 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42518 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 18 0.37 x 1000 cells/ul 0.04 0.16 automated blood cell counting method Moms and pups used in studies were fed Teklad 39668 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 15 0.25 x 1000 cells/ul 0.06 0.22 automated blood cell counting method Moms and pups used in studies were fed Teklad 39671 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 147.52 % 6.83 30.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54314 381
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 18 0.96 x 1000 cells/ul 0.12 0.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 43218 401
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 91.27 % 2.44 7.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54553 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 96.69 % 3.08 9.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53547 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 106.61 % 3.55 11.23 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53553 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 146.77 % 6.75 28.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53739 381
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 8 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59005 526
SHR/NCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 9 0.95 g/kg 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 59017 526
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 25 153.6 g 1.8 9.2 whole body digital scale Moms and pups used in studies were fed Teklad 59059 526
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 17 1.98 g/dl 0.03 0.14 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40547 401
SHR/NCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 11 5.09 x 1000 cells/ul 0.46 1.53 automated blood cell counting method Moms and pups used in studies were fed Dyets 40643 401
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 16 69.13 U/l 3.45 13.78 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40711 401
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 18 4.84 x 1000 cells/ul 0.41 1.72 automated blood cell counting method Moms and pups used in studies were fed Teklad 40920 401
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 22 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59541 526
SHR/NCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 16.24 ml/min/kg 0.96 2.87 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59640 526
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 16 4.69 mmol/l 0.14 0.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38063 401
SHR/NCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 7.73 mg/dl 0.75 2.36 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38228 401
SHR/NCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 11 7.78 mg/dl 0.28 0.94 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38234 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 15 2.97 x 1000 cells/ul 0.39 1.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 41500 401
SHR/NCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 14.52 g/dl 0.29 0.91 automated blood cell counting method Moms and pups used in studies were fed Dyets 41624 401
SHR/NCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Dyets 38366 401
SHR/NCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 16.76 pg 0.07 0.24 automated blood cell counting method Moms and pups used in studies were fed Dyets 38387 401
SHR/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 20 156.05 mg/dl 4.51 20.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38524 401
SHR/NCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 11 6.52 g/dl 0.09 0.3 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41842 401
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 20 0.19 mg/dl 0.02 0.09 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41862 401
SHR/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.28 g 0.04 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45399 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 257.93 beats/min 12.49 39.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47576 461
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 32.63 % 4.46 13.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48521 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 128.51 mmHg 4.91 17.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48621 461
SHR/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 51.6 mmHg 5.67 17.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48716 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 73.89 % 3.8 11.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48750 461
SHR/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 -0.42 degrees C 0.12 0.38 digital rectal thermometry Moms and pups used in studies were fed Dyets 16270 381
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 2 47.5 % 16.5 23.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55364 522
SHR/NCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 9 0.19 null 0.01 0.03 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 57721 526
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 1.13 null 0.09 0.23 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57747 526
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 20 13.31 ml/min/kg 0.75 3.33 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57794 526
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 5.49 mmHg 2.96 8.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16294 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -7.02 mmHg 1.01 2.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16316 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 -11.57 mmHg 0.75 2.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16320 381
SHR/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 4 0.95 degrees C 0.38 0.75 digital rectal thermometry Moms and pups used in studies were fed Dyets 16384 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 96.26 mmHg 1.98 6.86 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16412 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.53 ml 0.03 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16470 381
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 44.72 ml/min/kg 8.86 28.03 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57996 526
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 37.45 degrees C 0.13 0.58 digital rectal thermometry Moms and pups used in studies were fed Teklad 16566 381
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 32.17 % 5.35 13.11 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55991 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 -8.58 null 0.12 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56002 522
SHR/NCrl body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 177.0 g 2.1 6.7 whole body digital scale Moms and pups used in studies were fed Dyets 58454 526
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.19 umol/l 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54989 522
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 8 0.05 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55126 522
SHR/NCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 10 44.27 % 0.77 2.45 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 60120 526
SHR/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 1.76 g/mg 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56986 522
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 34.75 mmHg 1.46 3.57 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16060 381
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 140.97 mmHg 6.4 19.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45723 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 139.01 mmHg 6.08 21.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45726 461
SHR/NCrl body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 137.0 g 3.2 10.1 whole body digital scale Moms and pups used in studies were fed Teklad 47819 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 5.44 ml/min/g 0.5 1.58 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44712 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 41.37 % 14.02 44.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46846 461
SHR/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 48.78 mmHg 6.15 18.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48027 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 78.91 % 4.46 13.39 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46060 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 5.93 mmHg 0.23 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47191 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 7.89 ml/min/g 0.6 1.89 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46297 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 4 59.92 mmHg 30.71 61.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48492 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 56.32 mmHg 5.51 19.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45267 461
SHR/NCrl plasma sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood sitosterol amount not specified 77.0 days 2 6.25 mg/dl unspecified method 0.0 70535 1300
SHR/NCrl plasma campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood campesterol amount not specified 77.0 days 2 4.0 mg/dl unspecified method 0.0 plasma campesterol measurement test 70518 1300
SHR/NCrl liver campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver campesterol amount not specified 77.0 days 2 0.09 mg/g unspecified method 0.0 tissue campesterol measurement test 70523 1300
SHR/NCrl liver phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver phytosterol amount not specified 77.0 days 2 0.21 mg/g unspecified method 0.0 tissue lipid analysis 70553 1300
SHR/NCrl plasma total cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood cholesterol amount not specified 77.0 days 2 58.3 mg/dl unspecified method 0.0 70161 1300
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 151.69 mmHg 3.57 8.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15557 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 149.95 breaths/min 6.09 19.27 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15381 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 0.33 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15391 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.29 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15394 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 35.18 mmHg 1.33 3.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14474 381
SHR/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 435.5 beats/min 12.38 41.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14695 381
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 182.26 % 9.87 29.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53525 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.26 ml 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14882 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.32 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14889 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 19 110.61 breaths/min 5.37 23.39 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14929 381
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -12.33 beats/min 17.47 52.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51696 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -49.56 beats/min 32.32 91.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51699 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -32.18 beats/min 19.16 38.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51709 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.69 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51773 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 34.22 beats/min 12.04 36.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51853 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.77 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51868 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 21.1 mmHg 4.61 11.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51871 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 1.2 ml/min 0.09 0.22 urine creatinine analysis Moms and pups used in studies were fed Teklad 51949 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 0.78 ml/min 0.07 0.16 urine creatinine analysis Moms and pups used in studies were fed Teklad 51952 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.07 beats/min 14.76 36.15 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52056 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 159.87 mmHg 7.95 19.47 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52093 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 13.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50584 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -22.11 beats/min 15.52 43.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50621 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 24.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50722 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 380.26 beats/min 6.27 15.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50886 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 8.33 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50915 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 12.15 beats/min 5.65 13.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50982 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 2.47 mmHg 5.7 17.11 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51025 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51105 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 139.16 mmHg 4.78 13.51 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51149 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -16.07 beats/min 16.66 49.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51162 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Dyets 51175 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -22.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51235 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 321.19 beats/min 5.4 15.26 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51249 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 368.99 beats/min 4.04 12.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51288 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 10 30.45 mg/d 6.31 19.96 automated urine analysis Moms and pups used in studies were fed Dyets 51440 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 9 10.33 mg/d 1.94 5.81 automated urine analysis Moms and pups used in studies were fed Dyets 51443 481
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 192.79 % 6.51 28.39 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54073 381
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 7 1.08 ml/min 0.08 0.2 urine creatinine analysis Moms and pups used in studies were fed Dyets 51544 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 140.45 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51632 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 374.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50325 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.88 beats/min 7.63 18.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50364 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 7 10.95 ng/ml/h 1.24 3.28 radioimmunoassay Moms and pups used in studies were fed Dyets 50391 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 7 0.83 ng/ml/h 0.23 0.6 radioimmunoassay Moms and pups used in studies were fed Dyets 50464 481
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 11 31.76 mmHg 0.78 2.6 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13441 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.36 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13654 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 7.43 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14152 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 318.46 % 27.95 108.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14195 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 %change=VE during7-9 min hypercapnia/control during standard conditions 295.88 % 21.24 92.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14192 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 152.81 % 6.34 26.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13677 381
SHR/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 140.42 mmHg 5.26 12.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13890 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 0.41 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13917 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 14.73 mmHg 9.07 15.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14022 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 158.25 % 7.19 22.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14041 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 297.82 % 21.78 68.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14096 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.41 null 0.03 0.08 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19737 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19741 381
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 38.02 degrees C 0.16 0.49 digital rectal thermometry Moms and pups used in studies were fed Dyets 19749 381
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 12 136.75 mmHg 7.74 26.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19863 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 12.99 mmHg 0.98 2.39 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20735 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 86.41 ml/min 6.43 24.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20758 381
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 197.38 % 7.42 22.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53841 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 89.15 % 3.07 13.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53974 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 0.0 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19928 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 519.72 beats/min 10.53 33.3 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19966 381
SHR/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20033 381
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 146.97 mmHg 8.91 21.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19524 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 -0.52 degrees C 0.3 0.95 digital rectal thermometry Moms and pups used in studies were fed Dyets 19583 381
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 38.19 degrees C 0.18 0.55 digital rectal thermometry Moms and pups used in studies were fed Dyets 17570 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17615 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 148.67 breaths/min 5.94 18.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17693 381
SHR/NCrl body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 19 157.1 g 1.5 6.6 whole body digital scale Moms and pups used in studies were fed Dyets 17814 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 136.37 % 4.67 14.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17923 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 53.23 ml/min 4.41 13.96 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18077 381
SHR/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 8 38.13 degrees C 0.28 0.8 digital rectal thermometry Moms and pups used in studies were fed Teklad 18135 381
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 20 55.15 mg/dl 1.39 6.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37091 401
SHR/NCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 11 3.79 x 1000 cells/ul 0.38 1.27 automated blood cell counting method Moms and pups used in studies were fed Dyets 37308 401
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 15 37.69 degrees C 0.17 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 19066 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 402.69 beats/min 19.15 50.67 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17495 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 427.79 beats/min 11.17 43.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17500 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 -41.72 mmHg 2.11 5.18 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19455 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 -44.75 mmHg 2.02 6.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19460 381
SHR/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 38.31 degrees C 0.16 0.56 digital rectal thermometry Moms and pups used in studies were fed Teklad 18139 381
SHR/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 37.9 degrees C 0.22 0.57 digital rectal thermometry Moms and pups used in studies were fed Dyets 18220 381
SHR/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 4 38.2 degrees C 0.23 0.47 digital rectal thermometry Moms and pups used in studies were fed Dyets 18227 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 58.79 ml/min 3.95 17.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20202 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 382.98 beats/min 14.44 35.36 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20444 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 549.71 beats/min 4.91 9.82 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20536 381
SHR/NCrl heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.77 g 0.03 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49057 461
SHR/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 630.9 s 45.31 143.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49293 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 4 55.63 mmHg 23.8 47.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49612 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 19.29 % 3.47 10.97 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49638 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 27.29 % 4.54 13.61 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49692 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 15 58.27 mmHg 3.26 12.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49994 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 4 7.68 IU/g 0.46 0.93 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 50205 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 5 3.88 IU/g 0.53 1.18 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 50210 461
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 987.15 s 84.11 265.98 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50221 461
SHR/NCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 4.72 mmol/l 0.36 1.13 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42161 401
SHR/NCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 11 23.0 mmol/l 0.83 2.76 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42206 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 15 55.04 % 0.89 3.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 38988 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 20 106.9 mmol/l 0.35 1.59 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39111 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 17 108.41 mmol/l 0.67 2.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39114 401
SHR/NCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 0.73 x 1000 cells/ul 0.15 0.45 automated blood cell counting method Moms and pups used in studies were fed Dyets 39361 401
SHR/NCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.18 x 1000 cells/ul 0.03 0.1 automated blood cell counting method Moms and pups used in studies were fed Dyets 39503 401
SHR/NCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 4.15 g/dl 0.07 0.23 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39525 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 16 166.44 U/l 9.55 38.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42767 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 20 126.3 U/l 6.45 28.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42764 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 32.17 g/dl 0.12 0.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 39771 401
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 166.31 % 6.52 20.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54517 381
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 178.53 % 8.97 26.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53559 381
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 166.16 % 6.3 19.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53565 381
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 19 156.1 % 6.79 29.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53622 381
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 10 0.1 mmHg-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59011 526
SHR/NCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 11 0.81 g/kg 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 59023 526
SHR/NCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 105.4 mmol/l 0.56 1.78 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40521 401
SHR/NCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 169.6 mg/dl 9.16 28.97 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40669 401
SHR/NCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 47.76 % 0.78 2.6 automated blood cell counting method Moms and pups used in studies were fed Dyets 40687 401
SHR/NCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 11 60.0 U/l 3.34 11.06 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37687 401
SHR/NCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 44.1 U/l 5.07 16.02 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37681 401
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 24 1.44 g/kg 0.05 0.23 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59654 526
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 19 4.99 mmol/l 0.12 0.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38060 401
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 17 22.88 mmol/l 1.17 4.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38258 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 18 3.5 x 1000 cells/ul 0.34 1.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 41497 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 18 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41641 401
SHR/NCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 6.02 g/dl 0.12 0.37 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41836 401
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 5 5.82 ml/min/g 0.91 2.03 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46522 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 5 0.22 IU/g 0.03 0.06 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47560 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 135.07 mmHg 6.34 19.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48618 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 4.11 mmHg 0.41 1.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48920 461
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 73.0 % 5.91 15.63 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57298 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 99.56 % 0.34 1.01 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55381 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55378 522
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 9.12 mmHg 1.85 6.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16298 381
SHR/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.62 degrees C 0.19 0.6 digital rectal thermometry Moms and pups used in studies were fed Dyets 16337 381
SHR/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 -0.07 degrees C 0.36 0.96 digital rectal thermometry Moms and pups used in studies were fed Dyets 16377 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 92.52 mmHg 2.65 7.5 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16408 381
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 43.63 ml/min 2.32 10.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16684 381
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -6.88 null 0.12 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55707 522
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 0.37 null 0.04 0.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58107 526
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 14.63 mmHg 2.37 5.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16778 381
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 -8.77 null 0.21 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56008 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 9.75 % 1.97 5.57 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56210 522
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 22 0.05 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58483 526
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 2 45.5 % 2.5 3.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54977 522
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 25 0.37 null 0.01 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58727 526
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.31 umol/l 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54995 522
SHR/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 8 2.17 g/mg 0.17 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55012 522
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55129 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 51.44 % 3.36 10.09 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56447 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 0.35 E-7mole 0.18 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56794 522
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 10.29 ml/min/kg 0.74 2.23 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60084 526
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.08 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56884 522
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.58 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17354 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 0.61 ml 0.03 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17364 381
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 15 8.01 IU/g 0.91 3.52 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45707 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 9.31 ml/min/g 0.45 1.43 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46647 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 44.47 mmHg 5.42 15.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47698 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 121.64 mmHg 9.54 21.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45819 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 54.02 % 8.16 25.8 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45921 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 82.4 % 14.19 44.89 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46851 461
SHR/NCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.6 g/kg 0.18 0.57 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 46997 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 64.54 mmHg 8.68 26.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47905 461
SHR/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 43.24 % 15.12 47.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46024 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 7 7.71 ml/min/g 0.98 2.59 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46198 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 58.26 % 4.16 13.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47071 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 142.56 mmHg 5.65 16.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45009 461
SHR/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 871.53 s 90.47 286.09 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45126 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 55.05 mmHg 2.35 8.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46414 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 post-ischemic value/pre-ischemic value x 100% 62.41 % 11.33 45.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48292 461
SHR/NCrl brain sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain sitosterol amount not specified 77.0 days 2 0.01 mg/g unspecified method 0.0 tissue lipid analysis 70544 1300
SHR/NCrl brain phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain phytosterol amount not specified 77.0 days 2 0.03 mg/g unspecified method 0.0 tissue lipid analysis 70557 1300
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 151.71 mmHg 4.81 18.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15089 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 8.27 mmHg 5.89 10.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15190 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 16.14 mmHg 6.33 14.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15538 381
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 131.36 mmHg 1.4 3.71 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15550 381
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 31.88 ml/min 2.22 7.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15622 381
SHR/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 15 0.03 degrees C 0.23 0.89 digital rectal thermometry Moms and pups used in studies were fed Teklad 15666 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 391.25 beats/min 7.75 21.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15920 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 2 107.2 mmHg 4.7 6.65 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15986 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.3 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15230 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14909 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 98.2 breaths/min 4.73 18.31 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14932 381
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 0.65 ng/ml/h 0.25 0.6 radioimmunoassay Moms and pups used in studies were fed Teklad 51841 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 7.15 mEq/d 0.51 1.6 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51890 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 137.69 mmHg 5.58 13.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52005 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 13.71 mEq/d 0.45 1.42 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52016 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.29 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Dyets 52039 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 136.28 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52086 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 1.29 mmHg 2.0 4.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50607 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 10.43 mmHg 7.64 15.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50700 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.63 beats/min 18.33 44.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50725 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 41.52 mmHg 2.24 6.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50754 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 17.34 beats/min 5.18 12.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50985 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 4 0.59 ml/min 0.17 0.33 urine creatinine analysis Moms and pups used in studies were fed Teklad 51060 481
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 19 157.02 % 6.71 29.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54207 381
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 23.97 mmHg 6.39 12.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51189 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -60.76 beats/min 16.42 46.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51207 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 364.35 beats/min 14.69 41.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51285 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.28 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Teklad 51315 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Teklad 51318 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 30.72 mmHg 3.16 8.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51429 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 1.42 ml/min 0.18 0.41 urine creatinine analysis Moms and pups used in studies were fed Dyets 51550 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 10 1.03 mg/d 0.16 0.51 automated urine analysis Moms and pups used in studies were fed Dyets 51566 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 361.82 beats/min 5.01 14.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51585 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 2.21 mmHg 3.87 11.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51596 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 -4.86 mmHg 5.79 16.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51599 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 129.66 mmHg 2.23 5.45 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51635 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.27 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Teklad 51649 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 13.96 mmHg 1.62 4.85 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50374 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 105.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50423 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 12.97 beats/min 16.28 39.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50426 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 23.0 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50508 481
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 -0.01 null 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14768 381
SHR/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 161.74 mmHg 5.21 14.73 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13477 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 157.62 mmHg 8.16 21.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14322 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 147.31 mmHg 5.31 20.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14327 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 19 168.39 breaths/min 4.79 20.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17105 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 11 27.88 mmHg 0.63 2.1 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17237 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 135.95 mmHg 5.66 13.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13768 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 35.61 mmHg 1.38 3.37 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13840 381
SHR/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 167.7 mmHg 10.92 26.75 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13897 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 140.59 mmHg 8.48 18.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19707 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 169.46 mmHg 5.07 10.14 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19714 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 0.08 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19781 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.47 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20865 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 106.54 % 3.28 14.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53873 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 -0.07 null 0.03 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19924 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 504.53 beats/min 12.78 33.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19962 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 11 -4.43 mmHg 0.71 2.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20095 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -3.81 mmHg 1.44 4.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20091 381
SHR/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20615 381
SHR/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20620 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 55.37 mmHg 2.15 5.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19552 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.93 degrees C 0.24 0.73 digital rectal thermometry Moms and pups used in studies were fed Dyets 19576 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 -6.09 mmHg 0.99 2.43 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19625 381
SHR/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 38.03 degrees C 0.31 1.07 digital rectal thermometry Moms and pups used in studies were fed Teklad 17655 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.5 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17674 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 104.16 mmHg 2.58 6.32 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17698 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 98.57 mmHg 3.22 5.58 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17705 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 -8.2 mmHg 1.55 3.8 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17710 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -10.59 mmHg 0.49 0.99 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17717 381
SHR/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 421.83 beats/min 16.26 45.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17749 381
SHR/NCrl body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 20 265.2 g 2.9 13.1 whole body digital scale Moms and pups used in studies were fed Dyets 17811 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 130.1 % 7.9 23.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17916 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 0.39 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17976 381
SHR/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.32 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17979 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 409.01 beats/min 5.21 12.75 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18104 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 156.6 breaths/min 9.08 35.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16908 381
SHR/NCrl body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 9 179.0 g 2.2 6.7 whole body digital scale Moms and pups used in studies were fed Dyets 18498 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 28.16 mmHg 1.07 3.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18830 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 24.84 mmHg 1.28 4.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18834 381
SHR/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 98.3 mmHg 1.72 5.97 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18864 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 155.16 mmHg 7.05 17.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18950 381
SHR/NCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 11 0.17 mg/dl 0.01 0.05 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36281 401
SHR/NCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 32.93 g/dl 0.24 0.8 automated blood cell counting method Moms and pups used in studies were fed Dyets 36317 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 20 6.14 g/dl 0.05 0.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36956 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 17 5.94 g/dl 0.06 0.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36959 401
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 17 77.35 mg/dl 1.49 6.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37094 401
SHR/NCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 2.81 x 1000 cells/ul 0.45 1.35 automated blood cell counting method Moms and pups used in studies were fed Dyets 37302 401
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 66.93 ml/min 4.04 18.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18656 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 47.39 ml/min 2.53 10.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18659 381
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 26.95 ml/min 2.8 8.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18185 381
SHR/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 393.41 beats/min 4.55 10.18 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18204 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 161.36 breaths/min 6.82 30.5 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18259 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20167 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 436.11 beats/min 8.76 23.19 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20437 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 558.94 beats/min 12.78 28.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20529 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 0.08 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20541 381
SHR/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 16 562.96 s 69.18 276.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49296 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 8.5 % 3.25 9.75 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49393 461
SHR/NCrl heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 1.12 g 0.03 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49602 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 15 23.17 % 3.42 13.24 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49695 461
SHR/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 825.55 s 92.83 278.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50116 461
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 %change=VE during 2-3 min hypercapnia/control during standard conditions 300.4 % 17.13 74.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19205 381
SHR/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 17 3.96 g/dl 0.03 0.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42230 401
SHR/NCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 142.9 mmol/l 1.19 3.76 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39078 401
SHR/NCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 11 21.82 mg/dl 0.66 2.18 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42334 401
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 17.36 pg 0.08 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 42539 401
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 16.76 pg 0.08 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 42542 401
SHR/NCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 11 0.25 x 1000 cells/ul 0.07 0.23 automated blood cell counting method Moms and pups used in studies were fed Dyets 39509 401
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 20 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39570 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 32.11 g/dl 0.13 0.52 automated blood cell counting method Moms and pups used in studies were fed Teklad 39774 401
SHR/NCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.38 mg/dl 0.03 0.09 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 43092 401
SHR/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 169.44 % 14.68 44.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54511 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 150.45 % 6.35 20.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54565 381
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 22.26 ml/min/kg 1.77 5.01 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 58993 526
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 25 227.4 g 2.7 13.4 whole body digital scale Moms and pups used in studies were fed Teklad 59056 526
SHR/NCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 3.73 x 1000 cells/ul 0.42 1.25 automated blood cell counting method Moms and pups used in studies were fed Dyets 40637 401
SHR/NCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 11 158.36 mg/dl 5.18 17.19 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40675 401
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 20 60.8 U/l 3.32 14.86 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40708 401
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 20 7.8 mg/dl 0.14 0.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37588 401
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 25 1.19 g/kg 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59651 526
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 19.41 g/dl 0.23 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 37962 401
SHR/NCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 51.13 fl 0.26 0.82 automated blood cell counting method Moms and pups used in studies were fed Dyets 38206 401
SHR/NCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 15.71 g/dl 0.19 0.63 automated blood cell counting method Moms and pups used in studies were fed Dyets 41630 401
SHR/NCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 11 0.04 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Dyets 38372 401
SHR/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 17 0.97 g 0.02 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45402 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 5.1 ml/min/g 0.64 1.91 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46527 461
SHR/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1049.31 s 53.27 159.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46542 461
SHR/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 1077.22 s 53.4 160.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46545 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 5 0.3 IU/g 0.05 0.11 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47555 461
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 38.2 % 6.22 21.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48524 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 4.36 mmHg 0.28 0.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48915 461
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 65.1 % 4.5 14.22 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57301 522
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -7.19 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57405 522
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 20 10.18 ml/min/kg 0.55 2.46 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57592 526
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 36.15 ml/min 1.82 7.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16141 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 93.1 ml/min 7.43 23.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16242 381
SHR/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.07 degrees C 0.18 0.53 digital rectal thermometry Moms and pups used in studies were fed Dyets 16263 381
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 1.18 null 0.05 0.16 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57753 526
SHR/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.96 degrees C 0.17 0.51 digital rectal thermometry Moms and pups used in studies were fed Dyets 16330 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 27.41 mmHg 1.05 2.76 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16450 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 0.63 ml 0.03 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16467 381
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.97 null 0.17 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55493 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -8.36 null 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55498 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 -8.34 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55501 522
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 31.87 ml/min 2.29 9.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16687 381
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.22 null 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55728 522
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 37.61 degrees C 0.15 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 16806 381
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55967 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 26.38 % 4.44 12.57 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55994 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.69 E-7mole 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54591 522
SHR/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.12 g/mg 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56223 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.04 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56262 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 2 92.5 % 7.5 10.61 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56341 522
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 24 0.32 null 0.01 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58730 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 7 2.0 mg/kg 0.63 1.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58848 526
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -7.62 null 0.23 0.72 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55022 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 0.04 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56695 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 54.0 % 3.05 8.62 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56733 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 0.05 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56814 522
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 9.82 ml/min/kg 0.98 2.78 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60078 526
SHR/NCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 11 47.76 % 0.78 2.6 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 60126 526
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56849 522
SHR/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.09 g/mg 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56992 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 0.6 E-7mole 0.1 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57129 522
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 12 36.12 mmHg 1.31 4.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16064 381
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 310.62 beats/min 28.68 90.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47684 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 144.0 mmHg 8.38 26.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45845 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 146.47 mmHg 5.55 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45850 461
SHR/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 1134.27 s 100.61 318.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45882 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 53.73 mmHg 10.01 30.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47908 461
SHR/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 53.22 mmHg 4.86 14.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48030 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 112.64 mmHg 3.09 9.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44809 461
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 110.41 mmHg 5.49 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44812 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 99.02 % 3.95 11.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44912 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 5.62 mmHg 0.15 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47194 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 137.7 mmHg 8.82 27.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45004 461
SHR/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 44.94 % 11.52 36.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46316 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 0.42 IU/g 0.03 0.09 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47308 461
SHR/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 91.05 % 7.19 21.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48400 461
SHR/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 82.17 % 15.48 48.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48403 461
SHR/NCrl plasma phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood phytosterol amount not specified 77.0 days 2 10.3 mg/dl unspecified method 0.0 70548 1300
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 156.71 mmHg 5.9 16.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15084 381
SHR/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 5.79 mmHg 4.09 12.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15157 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 12 413.63 beats/min 10.58 36.64 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15925 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 -0.02 null 0.03 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15358 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 139.86 breaths/min 1.92 5.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15374 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 99.31 breaths/min 3.06 9.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14450 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 19 105.77 ml/min 4.95 21.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14494 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 85.69 ml/min 9.26 35.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14497 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 150.49 mmHg 9.72 19.45 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14671 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 111.0 mmHg 5.06 8.76 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15979 381
SHR/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 8 0.91 degrees C 0.34 0.96 digital rectal thermometry Moms and pups used in studies were fed Teklad 16012 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.25 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14902 381
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 1.53 ml/min 0.06 0.16 urine creatinine analysis Moms and pups used in studies were fed Dyets 51806 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 19.47 mmHg 4.39 10.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51972 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 156.06 mmHg 6.95 17.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52002 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.31 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Dyets 52045 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 75.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52053 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 356.76 beats/min 13.66 40.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50528 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 140.95 mmHg 2.98 8.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50648 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 45.88 mmHg 2.54 7.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50661 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 31.4 mmHg 8.7 17.4 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50658 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -21.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50682 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 149.76 mmHg 4.03 12.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50742 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 27.55 mmHg 4.09 11.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50757 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -1.39 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50776 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -15.47 mmHg 6.08 14.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50806 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 44.15 mmHg 3.53 10.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50969 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 1.24 mmHg 2.67 7.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51028 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -6.87 beats/min 2.38 6.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51092 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 6.71 mmHg 3.2 7.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51108 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 337.8 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51118 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 396.7 beats/min 7.86 19.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51121 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -0.23 mmHg 3.97 9.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51138 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -13.39 beats/min 9.16 18.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51159 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -2.44 beats/min 16.86 50.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51204 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -12.98 beats/min 20.48 40.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51223 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.32 mEq/d 0.09 0.28 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51273 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.45 mmHg 3.89 11.0 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51344 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -7.68 beats/min 19.7 39.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51354 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -37.73 beats/min 10.68 26.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51375 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 41.75 mmHg 2.35 7.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51426 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 9 0.75 mg/d 0.12 0.36 automated urine analysis Moms and pups used in studies were fed Teklad 51471 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 9 0.29 mg/d 0.05 0.16 automated urine analysis Moms and pups used in studies were fed Dyets 51569 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 21.07 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51661 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 26.33 mmHg 3.02 7.4 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51668 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 358.8 beats/min 16.08 39.38 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50332 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 17.21 mmHg 4.74 9.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50371 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 8 9.13 ng/ml/h 0.66 1.87 radioimmunoassay Moms and pups used in studies were fed Dyets 50396 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 7 0.9 ng/ml/h 0.26 0.68 radioimmunoassay Moms and pups used in studies were fed Dyets 50459 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 349.08 beats/min 20.02 40.03 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50476 481
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 167.82 breaths/min 5.97 26.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14788 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 144.07 breaths/min 4.5 19.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14791 381
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 heart rate during walking-heart rate during rest 65.27 beats/min 13.49 42.65 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13407 381
SHR/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 37.78 degrees C 0.18 0.79 digital rectal thermometry Moms and pups used in studies were fed Teklad 13553 381
SHR/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 15 37.71 degrees C 0.23 0.89 digital rectal thermometry Moms and pups used in studies were fed Teklad 13556 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 7.46 null 0.04 0.06 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14159 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 156.99 % 8.63 38.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13674 381
SHR/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 161.07 mmHg 11.33 22.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13775 381
SHR/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 483.74 beats/min 10.36 32.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13810 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 38.44 mmHg 0.93 2.07 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13847 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.33 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13920 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 2 16.68 mmHg 10.43 14.74 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14029 381
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 38.04 degrees C 0.19 0.61 digital rectal thermometry Moms and pups used in studies were fed Dyets 19756 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19776 381
SHR/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 149.42 mmHg 2.72 7.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19858 381
SHR/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 18.93 mmHg 2.35 7.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20881 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 106.96 % 3.84 16.29 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53871 381
SHR/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 115.11 mmHg 3.04 9.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19985 381
SHR/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20026 381
SHR/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 12 131.38 mmHg 6.09 21.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20061 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20163 381
SHR/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 166.22 breaths/min 9.79 29.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20677 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 54.23 mmHg 1.9 4.25 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19559 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 34.78 mmHg 1.07 2.15 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19571 381
SHR/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 302.55 % 17.2 54.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19606 381
SHR/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.57 ml 0.04 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17681 381
SHR/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 92.96 breaths/min 3.99 11.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17794 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 -50.94 mmHg 3.02 6.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17945 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 366.99 beats/min 23.28 46.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18111 381
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 101.25 beats/min 10.51 33.22 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18364 381
SHR/NCrl body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 10 307.0 g 3.1 9.8 whole body digital scale Moms and pups used in studies were fed Dyets 18505 381
SHR/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 7.36 null 0.05 0.07 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19022 381
SHR/NCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 11 264.55 U/l 6.56 21.76 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37061 401
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 28.08 mmHg 4.97 7.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19034 381
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 37.66 degrees C 0.17 0.74 digital rectal thermometry Moms and pups used in studies were fed Teklad 19063 381
SHR/NCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 10 9.42 mg/dl 0.17 0.54 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36601 401
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.36 degrees C 0.12 0.39 digital rectal thermometry Moms and pups used in studies were fed Dyets 18239 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 143.17 breaths/min 5.72 24.28 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18262 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 43.57 ml/min 2.34 9.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20205 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 -0.16 degrees C 0.21 0.92 digital rectal thermometry Moms and pups used in studies were fed Teklad 20303 381
SHR/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 126.91 mmHg 7.17 18.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20397 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 29.0 mmHg 4.54 7.86 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20420 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 53.93 mmHg 1.69 5.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20472 381
SHR/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 -0.11 null 0.05 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20570 381
SHR/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 196.97 beats/min 10.68 32.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48942 461
SHR/NCrl heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.94 g 0.03 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49054 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 5.38 mmHg 0.17 0.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49171 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.55 mmHg 0.12 0.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49174 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 17.02 % 4.71 14.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49390 461
SHR/NCrl heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.44 g 0.05 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49607 461
SHR/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 159.33 beats/min 8.29 16.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19175 381
SHR/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 37.97 degrees C 0.29 0.76 digital rectal thermometry Moms and pups used in studies were fed Dyets 19188 381
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 17 15.94 mmol/l 1.06 4.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42059 401
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 20 16.1 mmol/l 0.61 2.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42056 401
SHR/NCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 23.8 mmol/l 1.42 4.49 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42200 401
SHR/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 20 4.04 g/dl 0.03 0.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42227 401
SHR/NCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 11 143.09 mmol/l 1.0 3.3 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39084 401
SHR/NCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 22.1 mg/dl 1.09 3.45 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42328 401
SHR/NCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 8.66 x 10E6 cells/ul 0.15 0.48 automated blood cell counting method Moms and pups used in studies were fed Dyets 42380 401
SHR/NCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 9.24 x 10E6 cells/ul 0.16 0.53 automated blood cell counting method Moms and pups used in studies were fed Dyets 42386 401
SHR/NCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 11 78.64 mg/dl 2.31 7.67 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39210 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 15 10.55 x 10E6 cells/ul 0.16 0.6 automated blood cell counting method Moms and pups used in studies were fed Teklad 39234 401
SHR/NCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 11 4.31 g/dl 0.04 0.13 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39531 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 143.92 % 5.23 22.19 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54312 381
SHR/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 194.62 % 12.61 48.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54411 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 152.66 % 6.76 20.29 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54559 381
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.08 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 58865 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 14 1.42 mg/kg 0.26 0.99 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58903 526
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 159.18 % 10.25 30.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53728 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 148.83 % 5.57 17.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53734 381
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 19.0 ml/min/kg 1.26 3.77 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 58999 526
SHR/NCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 11 103.0 mmol/l 0.86 2.86 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40527 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 17 60.55 % 0.73 3.01 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59251 526
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 14 54.6 % 0.83 3.09 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59254 526
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 7.25 mg/dl 0.28 1.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37591 401
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 15 4.07 x 1000 cells/ul 0.51 1.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 40923 401
SHR/NCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 21.0 ml/min/kg 2.22 5.86 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59634 526
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 20 24.0 mmol/l 0.7 3.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38255 401
SHR/NCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 1.87 g/dl 0.07 0.22 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41590 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41644 401
SHR/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 133.19 mmHg 7.67 21.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45501 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 253.98 beats/min 15.59 62.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47579 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 71.03 mmHg 15.91 44.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48497 461
SHR/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 77.8 mmHg 6.82 21.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48721 461
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 18 12.32 ml/min/kg 0.97 4.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57595 526
SHR/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 28.66 ml/min 2.01 7.79 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16144 381
SHR/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 89.57 ml/min 6.12 18.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16235 381
SHR/NCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 11 0.22 null 0.01 0.03 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 57727 526
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 18 16.03 ml/min/kg 1.14 4.85 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57797 526
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 435.09 beats/min 6.64 17.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16354 381
SHR/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 383.91 beats/min 11.96 29.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16361 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 27.91 mmHg 0.96 2.14 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16457 381
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 36.66 ml/min/kg 2.94 9.76 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57993 526
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 37.27 degrees C 0.12 0.49 digital rectal thermometry Moms and pups used in studies were fed Teklad 16569 381
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -6.74 null 0.15 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55713 522
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.48 null 0.1 0.33 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58110 526
SHR/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 38.21 degrees C 0.14 0.59 digital rectal thermometry Moms and pups used in studies were fed Teklad 16809 381
SHR/NCrl body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 11 282.7 g 3.6 11.9 whole body digital scale Moms and pups used in studies were fed Dyets 58460 526
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.71 E-7mole 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54597 522
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 8 -7.33 null 0.1 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56175 522
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.51 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56178 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 17.5 % 2.32 5.68 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56207 522
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 19 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58486 526
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 8.25 % 2.75 7.78 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54851 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 6.4 % 3.45 10.9 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54857 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 2 85.0 % 15.0 21.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56335 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 2 33.0 % 3.0 4.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54983 522
SHR/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.51 g/mg 0.11 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55015 522
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -7.9 null 0.24 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55028 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 45.63 % 1.58 4.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56441 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56701 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 26.75 % 3.36 9.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56717 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 52.33 % 5.76 14.11 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56730 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 0.58 E-7mole 0.19 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56788 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.05 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56811 522
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56843 522
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.07 umol/l 0.03 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56878 522
SHR/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 6.65 g/kg 0.23 0.74 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45622 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 8.72 IU/g 0.86 2.72 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45704 461
SHR/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 114.93 mmHg 7.73 20.46 balloon tipped catheter with pressure transducer in isolated perfused heart 46744 461
SHR/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 40.51 mmHg 6.06 18.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47695 461
SHR/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1252.1 s 67.48 213.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45877 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 8.22 ml/min/g 0.87 2.6 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46864 461
SHR/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 15.86 % 9.64 30.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46955 461
SHR/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 42.93 % 11.09 35.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46960 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 83.28 % 14.61 43.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44915 461
SHR/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 59.66 % 11.34 35.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46029 461
SHR/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 963.56 s 107.72 340.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45121 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 243.51 beats/min 26.83 80.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45142 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 8.1 ml/min/g 0.41 1.23 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46302 461
SHR/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 58.91 % 7.35 22.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46313 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 57.84 mmHg 3.28 10.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46411 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.47 IU/g 0.07 0.21 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47314 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 0.4 IU/g 0.1 0.32 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47448 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 17 0.31 IU/g 0.05 0.2 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47452 461
SHR/NCrl liver sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver sitosterol amount not specified 77.0 days 2 0.12 mg/g unspecified method 0.0 tissue lipid analysis 70540 1300
SHR/NCrl brain cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain cholesterol amount not specified 77.0 days 2 11.76 mg/g unspecified method 0.0 tissue lipid analysis 70527 1300