Phenominer Database Results (555 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
F344/DuCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 13 112.28 mmHg 2.36 8.5 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15796 381
F344/DuCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 286.63 % 25.13 83.33 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15211 381
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51896 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 9 0.22 mg/dl 0.01 0.03 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51898 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -45.99 beats/min 11.57 30.62 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51991 481
F344/DuCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 9 23.85 mg/d 3.44 10.31 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52061 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -2.26 beats/min 17.07 45.17 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52071 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 413.17 beats/min 9.33 28.0 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50579 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 383.6 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50864 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 6.57 beats/min 9.35 22.89 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50892 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.2 beats/min 20.46 50.11 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50953 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -20.57 beats/min 11.12 29.43 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51037 481
F344/DuCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 172.72 % 11.52 38.21 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54177 381
F344/DuCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 167.6 % 5.41 17.95 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54183 381
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 1.04 ml/min 0.2 0.44 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51257 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 112.47 mmHg 2.22 5.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51391 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -48.94 beats/min 12.72 33.65 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51530 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 8.01 mEq/d 0.64 2.01 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51642 481
F344/DuCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 10 0.7 mg/d 0.25 0.8 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51672 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 8.4 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51676 481
F344/DuCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 -4.92 mmHg 0.56 1.68 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17199 381
F344/DuCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 89.88 beats/min 20.7 50.72 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17293 381
F344/DuCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 12 112.39 mmHg 3.16 10.96 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13879 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.32 ml 0.01 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14011 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.25 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14016 381
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.44 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14051 381
F344/DuCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 66.41 beats/min 11.36 30.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14113 381
F344/DuCrl blood glucose level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood glucose amount not specified 65.0 days 10 147.6 mg/dl 10.8 34.15 intraperitoneal glucose tolerance test tail vein glucose injection 30 min Reflolux II; BM-test Glycemie I-44 reagent strips (Boeringer-Mannheim, Germany) 11394 82
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 7.45 null 0.03 0.05 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20853 381
F344/DuCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -6.93 mmHg 0.87 2.45 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20983 381
F344/DuCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 123.3 mmHg 4.67 12.35 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20133 381
F344/DuCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 114.22 mmHg 4.72 14.91 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20138 381
F344/DuCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 405.3 beats/min 10.77 35.73 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19546 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 12 32.06 mmHg 0.89 3.09 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19691 381
F344/DuCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.64 degrees C 0.12 0.4 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17783 381
F344/DuCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 195.69 breaths/min 8.76 29.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17958 381
F344/DuCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.55 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18093 381
F344/DuCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 7.54 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18098 381
F344/DuCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 58.21 mmHg 1.3 3.18 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17014 381
F344/DuCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 408.27 beats/min 15.17 37.15 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18393 381
F344/DuCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 0.5 degrees C 0.17 0.56 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18510 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 40.16 ml/min 2.86 11.45 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18965 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 30.96 ml/min 1.47 6.22 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18970 381
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18988 381
F344/DuCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 18 5.94 g/dl 0.08 0.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36264 401
F344/DuCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 17 5.99 g/dl 0.08 0.33 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36269 401
F344/DuCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 18 154.44 mg/dl 4.36 18.51 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36322 401
F344/DuCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 17 157.94 mg/dl 5.18 21.34 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36327 401
F344/DuCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 18.61 pg 0.1 0.37 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36357 401
F344/DuCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 18.54 pg 0.12 0.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36362 401
F344/DuCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 17 66.59 mg/dl 4.34 17.91 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36465 401
F344/DuCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 9 16.89 mg/dl 0.92 2.76 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37285 401
F344/DuCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.46 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18521 381
F344/DuCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 18 9.44 mg/dl 0.41 1.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36718 401
F344/DuCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 74.59 % 8.86 28.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49270 461
F344/DuCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 794.53 s 20.12 63.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49482 461
F344/DuCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 735.13 s 39.12 117.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49489 461
F344/DuCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.22 g/kg 0.1 0.32 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49673 461
F344/DuCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 105.95 mmHg 4.27 13.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49783 461
F344/DuCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 47.41 % 0.48 1.28 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38865 401
F344/DuCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 8 0.21 mg/dl 0.07 0.2 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42178 401
F344/DuCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 17 4.4 mmol/l 0.11 0.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39100 401
F344/DuCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 17 254.24 U/l 11.22 46.27 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42354 401
F344/DuCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 9 141.78 mmol/l 1.1 3.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39340 401
F344/DuCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 18 18.67 mg/dl 0.64 2.72 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39514 401
F344/DuCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 32.36 g/dl 0.17 0.65 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42732 401
F344/DuCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 15.36 g/dl 0.18 0.49 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42742 401
F344/DuCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 8 4.47 x 1000 cells/ul 0.66 1.88 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42856 401
F344/DuCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 8 24.0 mmol/l 1.39 3.93 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43071 401
F344/DuCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 18 0.13 x 1000 cells/ul 0.03 0.12 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43086 401
F344/DuCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 163.78 % 7.54 25.01 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54540 381
F344/DuCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 19 183.11 mg/dl 10.78 46.98 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40493 401
F344/DuCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 14 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40504 401
F344/DuCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 4.3 mmol/l 0.22 0.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40648 401
F344/DuCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 17 3.77 mmol/l 0.11 0.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40653 401
F344/DuCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 17 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37549 401
F344/DuCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 17 0.24 mg/dl 0.01 0.05 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40805 401
F344/DuCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 18 14.61 mmol/l 0.38 1.61 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41124 401
F344/DuCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 17 14.53 mmol/l 0.49 2.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41129 401
F344/DuCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 18 17.74 pg 0.06 0.24 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41280 401
F344/DuCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 14 10.33 x 10E6 cells/ul 0.16 0.61 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38152 401
F344/DuCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 19 171.0 U/l 7.1 30.94 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38178 401
F344/DuCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 14 3.26 x 1000 cells/ul 0.34 1.27 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38217 401
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 244.42 beats/min 21.66 68.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46502 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 200.77 beats/min 14.47 43.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46509 461
F344/DuCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 73.71 % 9.56 28.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47550 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 138.4 mmHg 6.21 18.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47667 461
F344/DuCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 56.97 ml/min/kg 8.5 25.51 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57462 526
F344/DuCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 83.54 ml/min/kg 8.83 27.91 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57467 526
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 0.15 mmHg x min x kg x ml-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57684 526
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57689 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 13 3.49 mg/kg 0.6 2.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57771 526
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 17 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58085 526
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 12.63 ml/min/kg 1.99 5.98 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58307 526
F344/DuCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.19 null 0.01 0.04 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58443 526
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 11 59.93 % 0.64 2.13 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58590 526
F344/DuCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 19 1.06 g/kg 0.03 0.13 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58832 526
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 47.3 % 2.36 7.45 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56684 522
F344/DuCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 52.5 % 4.79 15.15 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56755 522
F344/DuCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.14 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56775 522
F344/DuCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -6.79 null 0.1 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56780 522
F344/DuCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 2.19 E-7mole 0.62 1.97 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56804 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 32.94 % 5.29 22.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56833 522
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 5.14 ml/min/g 0.35 1.1 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45892 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 10.67 ml/min/g 1.93 5.44 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45899 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 87.43 mmHg 9.01 25.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45911 461
F344/DuCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 55.89 % 2.3 7.26 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47885 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 5.35 mmHg 0.1 0.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48009 461
F344/DuCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 96.58 % 5.38 15.22 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46172 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 8.2 ml/min/g 0.66 2.1 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46177 461
F344/DuCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 251.86 beats/min 8.96 28.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48173 461
F344/DuCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 254.61 beats/min 10.75 32.25 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48180 461
F344/DuCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 56.81 mmHg 8.09 22.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47401 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 0.44 IU/g 0.04 0.12 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45233 461
F344/DuCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 511.78 beats/min 9.07 23.98 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15785 381
F344/DuCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 505.01 beats/min 12.58 39.79 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15790 381
F344/DuCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypercapnia/control during standard conditions 293.22 % 20.42 67.73 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14406 381
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 8 0.25 mg/dl 0.01 0.02 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51987 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -0.7 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50819 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 407.31 beats/min 7.86 23.58 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50856 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 385.1 beats/min 13.34 32.69 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50862 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 7.74 mmHg 2.21 5.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50858 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -42.8 beats/min 16.6 40.66 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50866 481
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 110.67 % 3.4 14.41 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54194 381
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 -5.94 mmHg 2.7 8.1 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51068 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -5.54 mmHg 2.16 6.48 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51066 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 14.0 mmHg 3.08 8.14 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51170 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 1.45 beats/min 8.08 24.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51261 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -7.69 beats/min 11.36 30.07 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51331 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 401.03 beats/min 10.58 27.99 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51619 481
F344/DuCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.53 degrees C 0.15 0.5 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14176 381
F344/DuCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.21 degrees C 0.11 0.37 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14181 381
F344/DuCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 7.62 mmHg 1.38 2.76 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14290 381
F344/DuCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 105.14 breaths/min 4.12 16.48 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17325 381
F344/DuCrl blood glucose level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood glucose amount not specified 65.0 days 10 64.8 mg/dl 3.6 11.38 intraperitoneal glucose tolerance test tail vein glucose injection 120 min Reflolux II; BM-test Glycemie I-44 reagent strips (Boeringer-Mannheim, Germany) 11396 82
F344/DuCrl change in blood insulin level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood insulin amount not specified 65.0 days 3 -3.2 mU/l 6.1 10.57 enzyme linked immunosorbent assay glucose injection 30 min 11399 82
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 32.82 ml/min 1.38 5.86 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19724 381
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20850 381
F344/DuCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 37.87 degrees C 0.13 0.57 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19949 381
F344/DuCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 419.77 beats/min 7.28 26.24 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19541 381
F344/DuCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 86.67 ml/min 3.85 12.77 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19588 381
F344/DuCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 106.95 mmHg 3.69 7.37 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17603 381
F344/DuCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 124.14 mmHg 2.74 6.71 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17600 381
F344/DuCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 190.4 breaths/min 6.9 22.88 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17963 381
F344/DuCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 373.96 beats/min 15.04 36.84 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18087 381
F344/DuCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 53.67 mmHg 1.36 3.85 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17009 381
F344/DuCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 14 57.48 fl 0.26 0.98 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36288 401
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 14 59.31 % 0.74 2.77 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36347 401
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 59.76 % 0.61 2.11 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36352 401
F344/DuCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 17 107.76 U/l 7.3 30.1 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37425 401
F344/DuCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19325 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 130.93 breaths/min 5.56 23.59 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18214 381
F344/DuCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 174.63 breaths/min 4.42 14.67 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20183 381
F344/DuCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 64.53 % 4.18 12.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49654 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 247.37 beats/min 10.62 33.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49973 461
F344/DuCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 -0.71 degrees C 0.17 0.71 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19162 381
F344/DuCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 19 9.74 mg/dl 0.45 1.96 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38842 401
F344/DuCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 18 4.16 mmol/l 0.14 0.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39095 401
F344/DuCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 17 9.52 mg/dl 0.12 0.49 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42528 401
F344/DuCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 19 3.8 g/dl 0.07 0.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39355 401
F344/DuCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 19 0.21 mg/dl 0.02 0.1 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39559 401
F344/DuCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 18 22.5 mmol/l 0.87 3.68 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43076 401
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 116.96 % 4.5 19.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53598 381
F344/DuCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 9 189.89 mg/dl 13.92 41.75 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40488 401
F344/DuCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 14 0.23 x 1000 cells/ul 0.04 0.16 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40692 401
F344/DuCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 18 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37544 401
F344/DuCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 18 55.02 fl 0.21 0.88 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37795 401
F344/DuCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 17 3.79 g/dl 0.04 0.17 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41139 401
F344/DuCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 8 3.27 x 1000 cells/ul 0.58 1.63 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37939 401
F344/DuCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 17.3 pg 0.08 0.22 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41275 401
F344/DuCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 10.38 x 10E6 cells/ul 0.13 0.45 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38157 401
F344/DuCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 7 95.29 U/l 16.59 43.9 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41613 401
F344/DuCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 19 60.37 U/l 6.84 29.8 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38621 401
F344/DuCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 81.69 % 1.68 5.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47543 461
F344/DuCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 0.03 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57433 522
F344/DuCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 18 1.23 g/kg 0.04 0.16 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57576 526
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 407.25 beats/min 7.98 26.46 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16130 381
F344/DuCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 -7.85 null 0.41 1.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55352 522
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 9 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57694 526
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 13 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57699 526
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.22 null 0.01 0.02 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57736 526
F344/DuCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 1.8 E-7mole 0.32 1.14 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55981 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 31.11 % 4.33 13.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56052 522
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.3 null 0.03 0.11 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58580 526
F344/DuCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 0.89 g/kg 0.04 0.14 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58827 526
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 29.0 % 4.31 18.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55005 522
F344/DuCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 -8.29 null 0.39 1.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55119 522
F344/DuCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 16 47.81 % 0.34 1.37 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59858 526
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 9.56 ml/min/kg 0.78 2.82 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59868 526
F344/DuCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 16 0.29 null 0.01 0.05 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59969 526
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 58.44 % 2.97 12.58 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56706 522
F344/DuCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 -7.5 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56737 522
F344/DuCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 84.1 % 2.15 6.79 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56750 522
F344/DuCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.05 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56765 522
F344/DuCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.79 E-7mole 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56799 522
F344/DuCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.23 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56818 522
F344/DuCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 54.81 ml/min/kg 3.83 13.8 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60136 526
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 99.91 % 0.09 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56859 522
F344/DuCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.06 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57005 522
F344/DuCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 -9.07 mmHg 0.34 0.9 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17463 381
F344/DuCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 112.6 mmHg 4.67 14.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46042 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 11.01 ml/min/g 0.8 2.41 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46184 461
F344/DuCrl body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 157.3 g 4.3 13.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47162 461
F344/DuCrl body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 118.9 g 2.1 6.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47167 461
F344/DuCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 119.34 mmHg 4.9 15.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45017 461
F344/DuCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 112.98 mmHg 6.2 17.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45024 461
F344/DuCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 47.0 mmHg 2.01 6.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47382 461
F344/DuCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 31.48 mmHg 6.24 19.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47394 461
F344/DuCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 30.31 ml/min 3.66 12.12 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15491 381
F344/DuCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 7.56 mmHg 5.05 15.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15517 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 91.79 mmHg 2.32 7.33 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15562 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 26.42 mmHg 0.7 2.1 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15627 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 25.81 mmHg 0.62 1.85 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15632 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 30.09 mmHg 1.37 3.62 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15368 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 21.49 mmHg 0.56 1.48 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14393 381
F344/DuCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during 2-3 min hypercapnia/control during standard conditions 316.87 % 29.35 97.35 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14401 381
F344/DuCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14432 381
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 7 1.34 ml/min 0.23 0.62 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51684 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 1.97 mmHg 2.32 5.68 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50543 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 61.4 beats/min 12.22 29.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50821 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -0.24 mmHg 4.62 12.21 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50999 481
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 98.76 % 1.9 7.62 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54199 381
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 117.34 mmHg 1.33 3.99 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51077 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 115.76 mmHg 2.14 6.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51079 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 5.85 beats/min 9.6 28.81 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51263 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 1.24 mEq/d 0.13 0.4 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51365 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.02 mmHg 2.22 5.88 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51418 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 3.06 beats/min 11.72 31.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51532 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 7 3.27 ng/ml/h 0.47 1.25 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51604 481
F344/DuCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 9 0.6 mg/d 0.1 0.31 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51670 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 121.63 mmHg 2.27 6.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50350 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 112.19 mmHg 3.96 10.47 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50352 481
F344/DuCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 119.59 mmHg 7.49 18.34 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13457 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 106.47 mmHg 1.82 5.47 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14300 381
F344/DuCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 -7.01 mmHg 0.56 1.67 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17204 381
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14046 381
F344/DuCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 18.18 mmHg 2.8 7.41 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14058 381
F344/DuCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 13.35 mmHg 4.38 7.58 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14061 381
F344/DuCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 105.14 mmHg 3.75 11.86 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14078 381
F344/DuCrl blood glucose level area under curve (AUC) fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood glucose amount not specified 65.0 days 10 11563.64 (mg/dl) x min 418.18 1322.41 intraperitoneal glucose tolerance test tail vein glucose injection Reflolux II; BM-test Glycemie I-44 reagent strips (Boeringer-Mannheim, Germany) 11397 82
F344/DuCrl blood insulin level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood insulin amount not specified 65.0 days 3 23.6 mU/l 4.9 8.49 enzyme linked immunosorbent assay glucose injection min 11398 82
F344/DuCrl change in blood insulin level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood insulin amount not specified 65.0 days 3 2.4 mU/l 8.0 13.86 enzyme linked immunosorbent assay 0 glucose injection 120 min 11400 82
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 40.7 ml/min 1.66 6.65 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19719 381
F344/DuCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 37.17 degrees C 0.17 0.72 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19998 381
F344/DuCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 16.59 mmHg 3.58 9.46 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20106 381
F344/DuCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 71.58 ml/min 3.62 12.0 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19593 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 30.72 mmHg 0.95 3.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19686 381
F344/DuCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 78.77 ml/min 3.23 10.72 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17582 381
F344/DuCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 30.33 ml/min 1.04 4.16 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17905 381
F344/DuCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 24.46 ml/min 1.29 5.47 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17910 381
F344/DuCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.59 degrees C 0.15 0.52 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18808 381
F344/DuCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 38.23 degrees C 0.21 0.7 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18803 381
F344/DuCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 -0.01 null 0.03 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18816 381
F344/DuCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 12 57.53 fl 0.24 0.82 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36293 401
F344/DuCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 18 0.56 x 1000 cells/ul 0.04 0.18 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36305 401
F344/DuCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 19 5.98 g/dl 0.18 0.78 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37420 401
F344/DuCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.23 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19044 381
F344/DuCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 8.87 x 10E6 cells/ul 0.12 0.33 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36573 401
F344/DuCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 105.22 breaths/min 7.94 26.35 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18158 381
F344/DuCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 112.81 breaths/min 8.04 26.65 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18163 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 129.3 breaths/min 4.39 17.55 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18209 381
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 7.51 % 1.5 4.73 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49031 461
F344/DuCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.67 g/kg 0.28 0.88 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49151 461
F344/DuCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 102.86 % 15.16 47.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49263 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 93.02 mmHg 7.25 22.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49275 461
F344/DuCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 46.5 mmHg 4.88 15.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49590 461
F344/DuCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 29.9 mmHg 3.66 11.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49597 461
F344/DuCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 71.26 % 12.9 38.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49661 461
F344/DuCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 4.89 g/kg 0.1 0.31 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49668 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 143.7 mmHg 6.26 18.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49803 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 144.34 mmHg 5.3 15.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49810 461
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 135.0 g 1.8 5.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50082 461
F344/DuCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 18 258.22 U/l 12.53 53.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42349 401
F344/DuCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 18 2.15 g/dl 0.05 0.22 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39215 401
F344/DuCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 19 145.37 mmol/l 1.13 4.95 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39345 401
F344/DuCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 14 4.26 x 1000 cells/ul 0.4 1.5 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39492 401
F344/DuCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 9 0.29 mg/dl 0.04 0.11 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39554 401
F344/DuCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 18 15.14 g/dl 0.25 1.05 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42747 401
F344/DuCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 18 3.43 x 1000 cells/ul 0.23 0.98 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42861 401
F344/DuCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 178.91 % 3.98 13.21 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54535 381
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 109.0 % 3.3 13.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53614 381
F344/DuCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 9 2.37 g/dl 0.17 0.5 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39979 401
F344/DuCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 19 2.18 g/dl 0.13 0.59 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39984 401
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.1 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59040 526
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.09 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59045 526
F344/DuCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 12 0.05 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40509 401
F344/DuCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 12 0.18 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40697 401
F344/DuCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 18 24.44 mmol/l 0.63 2.66 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37554 401
F344/DuCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 17 24.59 mmol/l 0.42 1.73 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37559 401
F344/DuCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 9 102.44 mmol/l 2.01 6.04 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41108 401
F344/DuCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 19 105.42 mmol/l 0.98 4.29 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41113 401
F344/DuCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 19 9.9 mg/dl 0.09 0.39 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37934 401
F344/DuCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 9 255.78 U/l 15.2 45.61 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38173 401
F344/DuCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 12 3.09 x 1000 cells/ul 0.26 0.9 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38222 401
F344/DuCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 18 145.0 mmol/l 0.8 3.4 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38239 401
F344/DuCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 16 143.81 mmol/l 0.61 2.43 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38244 401
F344/DuCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 17 88.82 U/l 10.15 41.84 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41618 401
F344/DuCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 19.27 g/dl 0.18 0.62 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38407 401
F344/DuCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 50.46 % 11.03 33.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47530 461
F344/DuCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 17 1.37 g/kg 0.08 0.34 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57581 526
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 12 441.09 beats/min 7.48 25.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16125 381
F344/DuCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 -8.31 null 0.08 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55347 522
F344/DuCrl body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 210.8 g 3.5 11.0 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57704 526
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 0.15 null 0.01 0.04 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57741 526
F344/DuCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 12 429.36 beats/min 6.47 22.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16436 381
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58090 526
F344/DuCrl body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 21 148.4 g 1.7 7.7 whole body digital scale Moms and pups used in studies were fed Dyets 16795 381
F344/DuCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.91 g/mg 0.19 0.59 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55865 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 27.67 % 4.21 12.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54645 522
F344/DuCrl body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 20 231.6 g 3.3 14.9 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56071 522
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 0.31 null 0.02 0.07 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58575 526
F344/DuCrl body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 141.2 g 1.6 4.9 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54877 522
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 20.03 ml/min/kg 1.59 6.54 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58837 526
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 15.9 ml/min/kg 1.49 5.37 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58842 526
F344/DuCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -8.38 null 0.09 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55114 522
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 12.32 ml/min/kg 0.86 3.54 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59863 526
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 53.28 % 3.23 13.72 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56711 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 33.72 % 3.82 16.19 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56828 522
F344/DuCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 66.44 ml/min/kg 5.57 22.97 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60131 526
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 99.43 % 0.43 1.13 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57124 522
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 138.79 mmHg 5.41 16.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47674 461
F344/DuCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 58.95 % 4.3 13.59 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45855 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 43.08 mmHg 7.1 22.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45904 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 49.94 mmHg 4.72 14.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45934 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.58 mmHg 0.12 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48016 461
F344/DuCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 107.36 mmHg 6.18 17.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46049 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 11.31 ml/min/g 0.95 2.69 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46160 461
F344/DuCrl heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.77 g 0.02 0.06 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48144 461
F344/DuCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 5.84 mmHg 0.06 0.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48159 461
F344/DuCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.8 g 0.03 0.11 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45031 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 14.79 ml/min/g 1.06 3.37 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45084 461
F344/DuCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 39.78 mmHg 3.38 10.13 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47389 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 0.54 IU/g 0.06 0.18 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45240 461
F344/DuCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 214.52 beats/min 14.26 40.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45362 461
F344/DuCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.45 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15527 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 98.95 mmHg 2.93 10.14 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15567 381
F344/DuCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 -0.01 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15602 381
F344/DuCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 115.14 mmHg 6.64 22.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15801 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 22.9 mmHg 1.37 2.36 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14396 381
F344/DuCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 288.9 % 20.09 66.63 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15216 381
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 111.8 mmHg 2.06 6.17 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51732 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 109.83 mmHg 2.62 7.87 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51734 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 18.8 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51913 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.29 mg/dl 0.02 0.05 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51985 481
F344/DuCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 10 24.49 mg/d 4.28 13.53 automated urine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52063 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -31.31 beats/min 14.7 38.9 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 52069 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 3.84 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50545 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 6.82 mmHg 1.9 4.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50817 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 38.89 mmHg 2.68 7.09 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50874 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 26.0 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50894 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -5.6 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50955 481
F344/DuCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 161.48 % 8.84 29.32 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54188 381
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 17.74 mmHg 4.17 11.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51168 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 1.72 mmHg 2.98 7.88 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51416 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 8 2.16 ng/ml/h 0.24 0.68 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51606 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 419.97 beats/min 10.58 27.98 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51617 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 7.87 mEq/d 1.47 4.17 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51640 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -7.77 beats/min 18.13 44.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51674 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 2.93 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50386 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 8 10.84 ng/ml/h 1.35 3.83 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50416 481
F344/DuCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 14.87 mmHg 3.2 7.84 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14287 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 104.79 mmHg 3.33 10.0 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14295 381
F344/DuCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 79.39 beats/min 11.46 22.91 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17296 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 %change=VE during7-9 min hypoxia/control during standard conditions 133.03 % 8.01 32.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17336 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 106.81 mmHg 1.35 3.57 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13820 381
F344/DuCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 -0.11 degrees C 0.19 0.63 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13868 381
F344/DuCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.57 degrees C 0.12 0.4 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13873 381
F344/DuCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 107.71 mmHg 3.73 9.86 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14083 381
F344/DuCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 71.79 beats/min 10.6 33.53 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14118 381
F344/DuCrl body weight control condition Galli J, et al., NatGenet 1996 Jan;12(1):31-7. body mass not specified 80.0 days 10 168.0 g 16.0 50.6 body weighing method 0 11401 82
F344/DuCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 -5.03 mmHg 0.92 2.26 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20988 381
F344/DuCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 13.64 mmHg 3.25 10.27 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20111 381
F344/DuCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 -51.21 mmHg 4.0 9.8 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20694 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 142.68 breaths/min 11.8 47.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17559 381
F344/DuCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 71.38 ml/min 4.88 16.18 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17587 381
F344/DuCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.78 degrees C 0.07 0.25 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17788 381
F344/DuCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 385.41 beats/min 7.25 20.5 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18082 381
F344/DuCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 119.63 mmHg 7.87 19.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18771 381
F344/DuCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 108.17 mmHg 2.41 8.0 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18777 381
F344/DuCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 525.85 beats/min 11.27 27.61 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18795 381
F344/DuCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 522.3 beats/min 2.74 5.48 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18798 381
F344/DuCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 -0.03 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18813 381
F344/DuCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 7.47 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18993 381
F344/DuCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 8 0.99 x 1000 cells/ul 0.12 0.33 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36300 401
F344/DuCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 19 17.05 mg/dl 0.79 3.46 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37290 401
F344/DuCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 15 87.13 U/l 4.48 17.34 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37430 401
F344/DuCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.29 ml 0.01 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19039 381
F344/DuCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 -0.35 degrees C 0.13 0.45 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18515 381
F344/DuCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.41 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18526 381
F344/DuCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 17 73.82 mg/dl 4.46 18.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36470 401
F344/DuCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 18 8.53 x 10E6 cells/ul 0.15 0.63 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36578 401
F344/DuCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 9.85 mg/dl 0.26 1.07 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36723 401
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 137.7 % 6.98 29.6 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19308 381
F344/DuCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19320 381
F344/DuCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 -0.41 degrees C 0.09 0.37 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19157 381
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 12.81 % 5.12 15.35 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49038 461
F344/DuCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.94 g/kg 0.23 0.73 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49146 461
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 12.86 % 6.61 20.92 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49857 461
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 5.94 % 2.48 7.45 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49864 461
F344/DuCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 9 11.06 mg/dl 1.08 3.23 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38837 401
F344/DuCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 18 46.87 % 0.8 3.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38870 401
F344/DuCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 19 0.2 mg/dl 0.06 0.25 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42183 401
F344/DuCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 19 22.37 mmol/l 1.23 5.37 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42364 401
F344/DuCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 14 0.76 x 1000 cells/ul 0.07 0.28 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42369 401
F344/DuCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 17 2.19 g/dl 0.05 0.22 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39220 401
F344/DuCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 18 9.41 mg/dl 0.16 0.68 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42523 401
F344/DuCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 17 18.82 mg/dl 0.67 2.77 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39519 401
F344/DuCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 32.27 g/dl 0.12 0.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42737 401
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 124.71 % 5.33 22.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54522 381
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 124.73 % 4.78 19.12 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54527 381
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 137.28 % 11.6 46.41 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53603 381
F344/DuCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 18 0.25 mg/dl 0.02 0.09 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40800 401
F344/DuCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 8 53.89 fl 0.51 1.45 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37790 401
F344/DuCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 19 98.89 mg/dl 2.76 12.04 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37913 401
F344/DuCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 9 9.57 mg/dl 0.41 1.23 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37929 401
F344/DuCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 17 110.0 mmol/l 1.06 4.39 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38188 401
F344/DuCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 18 0.02 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38352 401
F344/DuCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 7 55.14 U/l 3.47 9.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38616 401
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 7.29 ml/min/kg 0.83 2.49 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57452 526
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 10.34 ml/min/kg 1.4 4.85 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57457 526
F344/DuCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 60.46 % 5.97 21.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55385 522
F344/DuCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 74.42 % 3.91 13.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55390 522
F344/DuCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 434.78 beats/min 13.95 46.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16431 381
F344/DuCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 0.06 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16668 381
F344/DuCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16673 381
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 31.4 % 3.91 12.38 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54640 522
F344/DuCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 -6.81 null 0.07 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54746 522
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 14 59.31 % 0.74 2.77 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58585 526
F344/DuCrl body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 10 222.9 g 3.8 12.0 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54872 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 30.89 % 4.17 17.68 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55000 522
F344/DuCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 47.41 % 0.48 1.28 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59853 526
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 53.11 % 2.0 6.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56689 522
F344/DuCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 -7.61 null 0.07 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56742 522
F344/DuCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56770 522
F344/DuCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.32 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56823 522
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 17 152.2 g 7.0 28.8 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60104 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 12 2.98 mg/kg 0.68 2.34 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60114 526
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 99.71 % 0.29 1.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56854 522
F344/DuCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 1.19 g/mg 0.08 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56864 522
F344/DuCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 -11.72 mmHg 0.8 1.38 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17466 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.29 ml 0.01 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16035 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.25 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16040 381
F344/DuCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 71.83 % 10.26 30.79 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45862 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 37.33 mmHg 6.64 18.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45941 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 8.78 ml/min/g 0.3 0.94 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46153 461
F344/DuCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 89.45 % 3.7 11.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46165 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 7.12 IU/g 0.82 2.31 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47181 461
F344/DuCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 790.5 s 49.86 157.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48128 461
F344/DuCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 5.77 mmHg 0.08 0.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48166 461
F344/DuCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.65 g 0.03 0.1 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45038 461
F344/DuCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 54.57 % 8.37 23.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45050 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 17.24 ml/min/g 0.66 2.08 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45091 461
F344/DuCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 1011.89 s 25.81 81.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45104 461
F344/DuCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1125.42 s 55.97 177.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45111 461
F344/DuCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 68.03 mmHg 4.86 15.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47406 461
F344/DuCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 47.53 mmHg 7.01 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47413 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 0.38 IU/g 0.05 0.16 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48380 461
F344/DuCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 205.47 beats/min 7.89 24.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45355 461
F344/DuCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 26.17 ml/min 2.81 9.32 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15496 381
F344/DuCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 14.11 mmHg 3.25 9.75 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15512 381
F344/DuCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.38 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15532 381
F344/DuCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.73 degrees C 0.14 0.46 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15573 381
F344/DuCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.94 degrees C 0.13 0.47 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15578 381
F344/DuCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 -0.02 null 0.01 0.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15607 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 31.95 mmHg 0.82 2.58 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15363 381
F344/DuCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.23 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14437 381
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 9 1.22 ml/min 0.12 0.37 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51686 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 14.07 mmHg 1.28 3.13 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51911 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -88.23 beats/min 14.4 38.11 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51989 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 410.92 beats/min 6.97 20.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50577 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 16.8 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50823 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 409.47 beats/min 5.64 16.91 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50854 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.01 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50860 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 37.0 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50868 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 31.24 mmHg 2.72 7.19 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50876 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 -2.5 mmHg 2.9 7.67 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50997 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -55.8 beats/min 16.75 44.32 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51035 481
F344/DuCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 162.0 % 11.66 38.67 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54172 381
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 8 0.92 ml/min 0.08 0.22 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51259 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 46.11 beats/min 18.25 48.29 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51333 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 1.25 mEq/d 0.19 0.54 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51363 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 101.06 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51393 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 2.78 mmHg 1.91 4.67 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50384 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 7 15.17 ng/ml/h 1.06 2.81 radioimmunoassay Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50414 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 2.53 mmHg 2.7 7.13 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50452 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.4 mmHg 2.82 7.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50454 481
F344/DuCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 110.13 mmHg 2.89 8.16 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13452 381
F344/DuCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 107.06 breaths/min 5.59 23.73 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17330 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during7-9 min hypoxia/control during standard conditions 128.94 % 5.94 25.2 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17341 381
F344/DuCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 106.57 mmHg 3.8 6.57 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13823 381
F344/DuCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 113.26 mmHg 6.39 21.2 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13884 381
F344/DuCrl blood glucose level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood glucose amount not specified 65.0 days 10 55.8 mg/dl 5.4 17.08 intraperitoneal glucose tolerance test tail vein glucose injection min Reflolux II; BM-test Glycemie I-44 reagent strips (Boeringer-Mannheim, Germany) 11393 82
F344/DuCrl blood glucose level fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) Galli J, et al., NatGenet 1996 Jan;12(1):31-7. blood glucose amount not specified 65.0 days 10 93.6 mg/dl 7.2 22.77 intraperitoneal glucose tolerance test tail vein glucose injection 60 min Reflolux II; BM-test Glycemie I-44 reagent strips (Boeringer-Mannheim, Germany) 11395 82
F344/DuCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 175.77 % 11.68 38.75 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53852 381
F344/DuCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 196.88 % 17.41 57.75 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53857 381
F344/DuCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 16 37.76 degrees C 0.15 0.6 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19944 381
F344/DuCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 16 37.38 degrees C 0.12 0.46 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19993 381
F344/DuCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 -51.37 mmHg 4.19 11.86 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20689 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 123.56 breaths/min 6.1 25.9 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17564 381
F344/DuCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 419.5 beats/min 7.63 21.59 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18388 381
F344/DuCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 106.63 mmHg 2.22 6.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18766 381
F344/DuCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 12 103.7 mmHg 3.25 11.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18782 381
F344/DuCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 9 5.98 g/dl 0.3 0.91 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37415 401
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 134.28 % 3.49 13.97 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19303 381
F344/DuCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 173.67 breaths/min 5.04 16.73 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20178 381
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 112.32 mmHg 13.43 40.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49282 461
F344/DuCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 106.92 mmHg 2.54 7.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49790 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 241.21 beats/min 9.9 31.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49980 461
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 115.0 g 2.2 7.0 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50087 461
F344/DuCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 32.13 g/dl 0.28 0.8 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42211 401
F344/DuCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 18 32.29 g/dl 0.12 0.51 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42216 401
F344/DuCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 9 23.11 mmol/l 2.38 7.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42359 401
F344/DuCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 12 0.84 x 1000 cells/ul 0.05 0.18 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42374 401
F344/DuCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 9 3.61 g/dl 0.19 0.56 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39350 401
F344/DuCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 12 4.15 x 1000 cells/ul 0.28 0.97 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39497 401
F344/DuCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 8 0.21 x 1000 cells/ul 0.07 0.2 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43081 401
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 110.44 % 2.87 12.18 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53609 381
F344/DuCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 18 3.79 g/dl 0.04 0.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41134 401
F344/DuCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 9 69.11 mg/dl 4.29 12.86 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37908 401
F344/DuCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 18 2.74 x 1000 cells/ul 0.24 1.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37944 401
F344/DuCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 18 110.06 mmol/l 0.61 2.6 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38183 401
F344/DuCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 17 64.59 U/l 5.1 21.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41606 401
F344/DuCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 17 66.24 U/l 7.05 29.07 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41601 401
F344/DuCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 8 0.01 x 1000 cells/ul 0.01 0.01 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38347 401
F344/DuCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 14 19.2 g/dl 0.28 1.03 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38402 401
F344/DuCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 30.78 % 5.81 17.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47523 461
F344/DuCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57428 522
F344/DuCrl body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 19 141.4 g 1.7 7.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57709 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 14 3.69 mg/kg 0.79 2.96 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57766 526
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 25.74 mmHg 0.89 2.51 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16366 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 26.21 mmHg 0.43 1.05 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16371 381
F344/DuCrl body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 18 234.6 g 4.5 19.2 whole body digital scale Moms and pups used in studies were fed Dyets 16790 381
F344/DuCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.42 g/mg 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55860 522
F344/DuCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 1.72 E-7mole 0.66 2.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55986 522
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 14.15 ml/min/kg 1.66 5.76 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58312 526
F344/DuCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 19 0.17 null 0.01 0.04 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58448 526
F344/DuCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 -6.99 null 0.12 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54751 522
F344/DuCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 26.6 % 5.55 17.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56047 522
F344/DuCrl body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 20 155.9 g 3.1 13.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56076 522
F344/DuCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 0.06 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56455 522
F344/DuCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 0.65 10E-7mol/l 0.27 0.72 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56460 522
F344/DuCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 16 0.32 null 0.02 0.08 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59974 526
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 18 161.8 g 8.4 35.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60099 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 2.3 mg/kg 0.67 1.77 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60109 526
F344/DuCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 1.48 g/mg 0.08 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56869 522
F344/DuCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.06 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57000 522
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 98.0 % 1.07 2.83 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57119 522
F344/DuCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 56.39 % 7.12 22.52 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47892 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 5.03 IU/g 0.73 2.3 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47176 461
F344/DuCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 746.35 s 33.36 105.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48121 461
F344/DuCrl heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.62 g 0.02 0.06 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48151 461
F344/DuCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 26.7 % 4.41 13.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45043 461
F344/DuCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 998.39 s 28.58 90.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45067 461
F344/DuCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 1009.98 s 43.45 130.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45074 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.56 IU/g 0.05 0.17 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48387 461