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Term:
hydroxymethylglutaryl-CoA reductase (NADH) activity (GO:0140643)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
(+)-borneol dehydrogenase activity 
(+)-neomenthol dehydrogenase activity 
(+)-sabinol dehydrogenase activity 
(+)-trans-carveol dehydrogenase activity 
(-)-borneol dehydrogenase activity 
(-)-menthol dehydrogenase activity 
(3R)-2'-hydroxyisoflavanone reductase activity 
(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity  
(R)-2-hydroxy-fatty acid dehydrogenase activity 
(R)-2-hydroxyacid dehydrogenase activity 
(R)-2-hydroxyisocaproate dehydrogenase activity 
(R)-3-hydroxyacid-ester dehydrogenase activity 
(R)-4-hydroxyphenyllactate dehydrogenase (NADP+) activity 
(R)-aminopropanol dehydrogenase activity 
(R)-lactaldehyde dehydrogenase activity 
(R)-sulfopropanediol 2-dehydrogenase activity 
(R,R)-butanediol dehydrogenase activity  
(S)-2-hydroxy-fatty acid dehydrogenase activity 
(S)-3-hydroxyacid-ester dehydrogenase activity 
(S)-carnitine 3-dehydrogenase activity 
(S)-usnate reductase activity 
(S,S)-butanediol dehydrogenase activity 
1,3-propanediol dehydrogenase activity 
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity 
1,5-anhydro-D-fructose reductase activity  
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity 
10-hydroxygeranial oxidoreductase activity 
10-hydroxygeraniol oxidoreductase activity 
10-oxogeraniol oxidoreductase activity 
11-cis-retinol dehydrogenase  
11-cis-retinol dehydrogenase activity  
11-deoxycorticosterone reductase activity 
13-lipoxin reductase activity  
15-hydroxyicosatetraenoate dehydrogenase activity 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity  
15-hydroxyprostaglandin dehydrogenase (NADP+) activity  
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity  
15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity 
16-hydroxypalmitate dehydrogenase activity  
2,5-didehydrogluconate reductase activity 
2-(R)-hydroxypropyl-CoM dehydrogenase activity 
2-(S)-hydroxypropyl-CoM dehydrogenase activity 
2-alkyn-1-ol dehydrogenase activity 
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity 
2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity 
2-dehydropantoate 2-reductase activity 
2-dehydropantolactone reductase activity +  
2-deoxy-D-gluconate 3-dehydrogenase activity 
2-hydroxy-3-oxopropionate reductase activity 
2-hydroxymethylglutarate dehydrogenase activity 
2-oxoadipate reductase activity 
3''-deamino-3''-oxonicotianamine reductase activity 
3-(imidazol-5-yl)lactate dehydrogenase activity 
3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity 
3-alpha-hydroxycholanate dehydrogenase activity 
3-alpha-hydroxyglycyrrhetinate dehydrogenase activity 
3-dehydro-L-gulonate 2-dehydrogenase activity 
3-dehydrosphinganine reductase activity  
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity  
3-hydroxyacyl-CoA dehydrogenase activity +   
3-hydroxybenzyl-alcohol dehydrogenase activity 
3-hydroxybutyrate dehydrogenase activity  
3-hydroxybutyryl-CoA dehydrogenase activity 
3-hydroxyisobutyrate dehydrogenase activity  
3-hydroxypimeloyl-CoA dehydrogenase activity 
3-hydroxypropionate dehydrogenase (NAD+) activity 
3-hydroxypropionate dehydrogenase (NADP+) activity 
3-isopropylmalate dehydrogenase activity 
3-ketoglucose-reductase activity 
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity 
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity  
3-sulfolactaldehyde reductase activity 
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity 
4-(hydroxymethyl)benzenesulfonate dehydrogenase activity 
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity 
4-hydroxy-L-isoleucine dehydrogenase activity 
4-hydroxybutyrate dehydrogenase activity 
4-hydroxycyclohexanecarboxylate dehydrogenase activity 
4-hydroxythreonine-4-phosphate dehydrogenase activity 
4-oxoproline reductase activity  
4-phosphoerythronate dehydrogenase activity 
5'-hydroxyaverantin dehydrogenase activity 
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity 
5-amino-6-(5-phosphoribosylamino)uracil reductase activity 
5-exo-hydroxycamphor dehydrogenase activity 
5-hydroxyvalerate dehydrogenase activity 
6-endo-hydroxycineole dehydrogenase activity 
6-hydroxyhexanoate dehydrogenase activity 
6-pyruvoyltetrahydropterin 2'-reductase activity 
8-hydroxygeraniol dehydrogenase activity 
8-oxocoformycin reductase activity 
acetoacetyl-CoA reductase activity  
acetoin dehydrogenase (NAD+) activity +  
acylglycerone-phosphate reductase (NADP+) activity  
alcohol dehydrogenase [NAD(P)+] activity +   
aldose 1-dehydrogenase activity 
aldose-6-phosphate reductase (NADPH) activity 
allyl-alcohol dehydrogenase activity  
apiose 1-reductase activity 
aryl-alcohol dehydrogenase (NADP+) activity 
benzil reductase [(S)-benzoin-forming] activity 
benzyl-2-methyl-hydroxybutyrate dehydrogenase activity 
carnitine 3-dehydrogenase activity 
carveol dehydrogenase activity 
chlordecone reductase activity  
chlorophyll(ide) b reductase activity 
cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity  
cinnamyl-alcohol dehydrogenase activity 
codeinone reductase (NADPH) activity 
coniferyl-alcohol dehydrogenase activity 
cyclohexane-1,2-diol dehydrogenase activity 
cyclohexanol dehydrogenase activity 
cyclopentanol dehydrogenase activity 
D-arabinitol 2-dehydrogenase activity 
D-arabinitol 4-dehydrogenase activity 
D-arabinitol dehydrogenase (NADP+) activity 
D-arabinose 1-dehydrogenase [NAD(P)+] activity +  
D-fructuronate reductase activity 
D-galacturonate reductase activity 
D-iditol 2-dehydrogenase activity 
D-lactate dehydrogenase activity  
D-malate dehydrogenase (decarboxylating) (NAD+) activity 
D-pinitol dehydrogenase activity 
D-threo-aldose 1-dehydrogenase activity 
D-xylose 1-dehydrogenase (NAD+) activity 
D-xylose 1-dehydrogenase (NADP+) activity  
D-xylulose reductase activity  
diethyl 2-methyl-3-oxosuccinate reductase activity 
dihydrobunolol dehydrogenase activity 
dihydrokaempferol 4-reductase activity 
diiodophenylpyruvate reductase activity  
dimethylmalate dehydrogenase activity 
dTDP-4-dehydro-6-deoxyglucose reductase activity 
dTDP-4-dehydrorhamnose reductase activity 
dTDP-6-deoxy-L-talose 4-dehydrogenase activity 
dTDP-galactose 6-dehydrogenase activity 
erythrulose reductase activity 
farnesol dehydrogenase activity  
flavanone 4-reductase activity 
fluoren-9-ol dehydrogenase activity 
fructose 5-dehydrogenase (NADP+) activity 
fructuronate reductase activity 
galactitol 2-dehydrogenase activity 
galactitol-1-phosphate 5-dehydrogenase activity 
galactose 1-dehydrogenase (NADP+) activity 
galactose 1-dehydrogenase activity 
GDP-4-dehydro-6-deoxy-D-mannose reductase activity 
GDP-4-dehydro-D-rhamnose reductase activity  
GDP-6-deoxy-D-talose 4-dehydrogenase activity 
GDP-L-fucose synthase activity  
GDP-mannose 6-dehydrogenase activity 
geraniol dehydrogenase activity 
gluconate dehydrogenase activity +  
glucose 1-dehydrogenase [NAD(P)+] activity +   
glucose-6-phosphate 3-dehydrogenase activity 
glucose-6-phosphate dehydrogenase activity  
glucuronolactone reductase activity  
glycerol 2-dehydrogenase (NADP+) activity 
glycerol dehydrogenase [NAD(P)+] activity +   
glycerol-1-phosphate dehydrogenase [NAD(P)+] activity +  
glycerol-3-phosphate 1-dehydrogenase (NADP+) activity 
glycerol-3-phosphate dehydrogenase (NAD+) activity  
glycerol-3-phosphate dehydrogenase (NADP+) activity 
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity  
glyoxylate reductase activity +   
histidinol dehydrogenase activity 
homoisocitrate dehydrogenase activity 
homoserine dehydrogenase activity 
hydroxycyclohexanecarboxylate dehydrogenase activity 
hydroxymalonate dehydrogenase activity 
hydroxymethylfurfural reductase (NADH) activity 
hydroxymethylfurfural reductase (NADPH) activity 
hydroxymethylfurfural reductase activity 
hydroxymethylglutaryl-CoA reductase (NADH) activity 
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
hydroxymethylglutaryl-CoA reductase (NADPH) activity  
hydroxyphenylpyruvate reductase activity  
hydroxypyruvate reductase [NAD(P)H] activity +   
hydroxyversicolorone reductase activity 
IMP dehydrogenase activity  
indanol dehydrogenase activity  
indole-3-acetaldehyde reductase (NADPH) activity 
indolelactate dehydrogenase (NAD+) activity 
isocitrate dehydrogenase [NAD(P)+] activity +   
isocitrate-homoisocitrate dehydrogenase activity 
isopiperitenol dehydrogenase activity 
isopropanol dehydrogenase (NADP+) activity 
ketol-acid reductoisomerase activity 
L-2-hydroxycarboxylate dehydrogenase (NAD+) activity 
L-arabinitol 2-dehydrogenase activity 
L-arabinitol 4-dehydrogenase activity 
L-arabinose 1-dehydrogenase (NAD+) activity 
L-arabinose 1-dehydrogenase (NADP+) activity 
L-galactose dehydrogenase activity 
L-glucuronate reductase activity  
L-glyceraldehyde 3-phosphate reductase activity 
L-glycol dehydrogenase activity 
L-gulonate 3-dehydrogenase activity  
L-idonate 5-dehydrogenase (NAD+) activity 
L-idonate 5-dehydrogenase [NAD(P)+] activity 
L-lactate dehydrogenase activity  
L-malate dehydrogenase (NAD+) activity  
L-malate dehydrogenase (NADP+) activity  
L-rhamnose 1-dehydrogenase activity 
L-threonate 3-dehydrogenase activity 
L-threonine 3-dehydrogenase activity  
L-xylose 1-dehydrogenase activity 
L-xylulose reductase (NADH) activity 
L-xylulose reductase (NADPH) activity  
lactaldehyde reductase (NADPH) activity 
lactaldehyde reductase activity +  
long-chain-alcohol dehydrogenase activity 
malate dehydrogenase (decarboxylating) (NAD+) activity  
malate dehydrogenase (decarboxylating) (NADP+) activity  
mannitol 2-dehydrogenase (NADP+) activity 
mannitol 2-dehydrogenase activity 
mannitol dehydrogenase activity 
mannitol-1-phosphate 5-dehydrogenase activity 
mannose-6-phosphate 6-reductase activity 
mannuronate reductase activity 
methylglyoxal reductase (NADH) activity 
methylglyoxal reductase (NADPH) (acetol producing) activity  
methylglyoxal reductase (NADPH) activity 
mithramycin dehydrogenase activity 
momilactone-A synthase activity 
morphine 6-dehydrogenase activity 
N-acetylhexosamine 1-dehydrogenase activity 
N-acylmannosamine 1-dehydrogenase activity 
omega-hydroxydecanoate dehydrogenase activity  
oxaloglycolate reductase (decarboxylating) activity 
pantoate 4-dehydrogenase activity 
phenylacetaldehyde reductase activity 
phenylcoumaran benzylic ether reductase activity 
phenyllactate dehydrogenase (NAD+) activity 
phosphogluconate 2-dehydrogenase activity 
phosphogluconate dehydrogenase (decarboxylating) activity  
phosphoglycerate dehydrogenase activity  
propanediol-phosphate dehydrogenase activity 
prostaglandin D2 11-ketoreductase activity  
prostaglandin E2 9-reductase activity  
prostaglandin F synthase activity  
prostaglandin H2 endoperoxidase reductase activity  
pyridoxal 4-dehydrogenase activity 
quinate 3-dehydrogenase (NAD+) activity 
quinate 3-dehydrogenase (NADP+) activity 
ribitol 2-dehydrogenase (NAD+) activity  
ribitol-5-phosphate 2-dehydrogenase [(NAD(P)+] activity 
ribose 1-dehydrogenase (NADP+) activity 
S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity +   
S-nitrosoglutathione reductase (NADH) activity  
S-nitrosoglutathione reductase (NADPH) activity  
S-sulfolactate dehydrogenase activity 
salutaridine reductase (NADPH) activity 
scyllo-inositol dehydrogenase (NADP+) activity 
secoisolariciresinol dehydrogenase activity 
sepiapterin reductase (NADP+) activity  
sequoyitol dehydrogenase activity 
serine 3-dehydrogenase activity 
shikimate 3-dehydrogenase (NAD+) activity 
shikimate 3-dehydrogenase (NADP+) activity 
sorbitol-6-phosphate 2-dehydrogenase activity 
sorbose 5-dehydrogenase (NADP+) activity 
sorbose reductase activity 
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +   
sulcatone reductase activity 
tagaturonate reductase activity 
tartrate dehydrogenase activity 
tetrahydroxynaphthalene reductase activity 
tropine dehydrogenase activity 
tropinone reductase activity 
UDP-3-dehydro-alpha-D-glucose dehydrogenase activity 
UDP-4-keto-rhamnose-4-keto-reductase activity 
UDP-glucose 6-dehydrogenase activity  
UDP-glucuronic acid dehydrogenase activity 
UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity 
UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity 
UDP-N-acetyl-D-mannosamine dehydrogenase activity 
UDP-N-acetylglucosamine 6-dehydrogenase activity 
UDP-N-acetylmuramate dehydrogenase activity 
ureidoglycolate dehydrogenase activity 
uronate dehydrogenase activity 
vellosimine dehydrogenase activity 
versiconal hemiacetal acetate reductase activity 
versiconal reductase activity 
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity 
very-long-chain 3-oxoacyl-CoA reductase activity  
vomifoliol 4'-dehydrogenase activity 
zerumbone synthase activity 

Synonyms
Broad Synonyms: 3-hydroxy-3-methylglutaryl coenzyme A reductase activity ;   HMG-CoA reductase activity ;   beta-hydroxy-beta-methylglutaryl CoA-reductase activity ;   beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity ;   hydroxymethylglutaryl coenzyme A reductase activity
Xrefs: EC:1.1.1.88 ;   KEGG_REACTION:R02081 ;   MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN ;   RHEA:14833
Never In Taxon: NCBITaxon:2759 ! Eukaryota
Definition Sources: PMID:29224355, RHEA:14833

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