malate dehydrogenase (decarboxylating) (NADP+) activity - Ontology Report

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Term:	malate dehydrogenase (decarboxylating) (NADP+) activity	go back to main search page
Accession:	GO:0004473	browse the term
Definition:	Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
Comment:	For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
Synonyms:	related_synonym:	'malic' enzyme; (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating); L-malate:NADP oxidoreductase activity; NADP-linked decarboxylating malic enzyme; NADP-malic enzyme activity; NADP-specific malate dehydrogenase activity; NADP-specific malic enzyme; malate dehydrogenase (decarboxylating, NADP)
	xref:	EC:1.1.1.40; KEGG_REACTION:R00216; MetaCyc:MALIC-NADP-RXN; RHEA:18253; Reactome:R-HSA-9012036 "ME1 tetramer decarboxylates MAL to PYR"; Reactome:R-HSA-9012349 "ME3 tetramer decarboxylates MAL to PYR"

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Genes (3)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Me1

malic enzyme 1

enables

GO_REF:0000107
PMID:8187880
PMID:2416344
(PMID:7757881), (PMID:8187880), (PMID:8804575)
GO_REF:0000118
GO_REF:0000033
(PMID:18802677), (PMID:6838491)

GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:8554832, RGD:8554490

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

malic enzyme 2

enables

GO_REF:0000033

GO_REF:0000033

NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987

malic enzyme 3

enables

(PMID:7818469)
GO_REF:0000033
(PMID:25711)

GO_REF:0000033

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

Term paths to the root

Path 1
Term	Annotations
molecular_function	21010
catalytic activity	6145
oxidoreductase activity	871
oxidoreductase activity, acting on CH-OH group of donors	173
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	164
malate dehydrogenase (decarboxylating) (NADP+) activity	3
Path 2
Term	Annotations
molecular_function	21010
catalytic activity	6145
oxidoreductase activity	871
oxidoreductase activity, acting on CH-OH group of donors	173
malate dehydrogenase activity	7
malic enzyme activity	3
malate dehydrogenase (decarboxylating) (NADP+) activity	3

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