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Ontology Browser

Term:
mRNA cleavage and polyadenylation specificity factor complex (GO:0005847)
Annotations: Rat: (20) Mouse: (19) Human: (24) Chinchilla: (13) Bonobo: (16) Dog: (13) Squirrel: (17) Pig: (18) Naked Mole-rat: (16) Green Monkey: (17)
Parent Terms Term With Siblings Child Terms
mRNA cleavage and polyadenylation specificity factor complex  
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
mRNA cleavage stimulating factor complex  

Synonyms
Narrow Synonyms: CPF complex ;   CPSF complex
Related Synonyms: CFII complex ;   cleavage and polyadenylylation specificity factor activity
Definition Sources: PMID:14749727

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