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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA cleavage and polyadenylation specificity factor complex
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Accession:GO:0005847 term browser browse the term
Definition:A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
Synonyms:narrow_synonym: CPF complex;   CPSF complex
 related_synonym: CFII complex;   cleavage and polyadenylylation specificity factor activity


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mRNA cleavage and polyadenylation specificity factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpsf1 cleavage and polyadenylation specific factor 1 part_of ISO
IBA		 (PMID:21102410), (PMID:7590244)
GO_REF:0000033		 RGD
GO_Central		 PMID:7590244 PMID:21102410 GO_REF:0000033 NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934 		JBrowse link
G Cpsf2 cleavage and polyadenylation specific factor 2 part_of ISO
IBA		 (PMID:18305108), (PMID:21102410)
GO_REF:0000033
(PMID:16115198)		 RGD
GO_Central		 PMID:16115198 PMID:18305108 PMID:21102410 GO_REF:0000033 NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921 		JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 part_of ISO
IBA		 (PMID:18305108), (PMID:21102410), (PMID:8929409)
GO_REF:0000033
(PMID:16115198)		 RGD
GO_Central		 PMID:8929409 PMID:16115198 PMID:18305108 PMID:21102410 GO_REF:0000033 NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128 		JBrowse link
G Cpsf4 cleavage and polyadenylation specific factor 4 part_of ISO
ISS
IEA
IBA		 (PMID:21102410)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:21102410 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr12:9,429,765...9,445,586
Ensembl chr12:9,429,523...9,445,586 		JBrowse link
G Cpsf4-ps1 cleavage and polyadenylation specific factor 4, pseudogene 1 part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr  X:15,862,098...15,862,850
Ensembl chr  X:15,861,367...15,863,381 		JBrowse link
G Cpsf4l cleavage and polyadenylation specific factor 4-like part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:98,741,816...98,756,069
Ensembl chr10:98,743,649...98,751,590 		JBrowse link
G Cpsf4l2 cleavage and polyadenylation specific factor 4 like 2 part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr12:10,211,744...10,213,512
Ensembl chr12:10,211,798...10,212,670 		JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 part_of ISO
IBA		 (PMID:23187700)
GO_REF:0000033		 RGD
GO_Central		 PMID:23187700 GO_REF:0000033 NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122 		JBrowse link
G Cpsf7 cleavage and polyadenylation specific factor 7 part_of ISO
IEA
IBA		 (PMID:23187700)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:23187700 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:207,167,690...207,191,938
Ensembl chr 1:207,167,859...207,191,905 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 part_of
located_in		 IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:18305108)		 Ensembl
UniProt
RGD		 PMID:18305108 GO_REF:0000024 GO_REF:0000107 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 part_of ISO
IBA		 (PMID:18305108), (PMID:21102410)
GO_REF:0000033		 RGD
GO_Central		 PMID:18305108 PMID:21102410 GO_REF:0000033 NCBI chr  X:97,253,559...97,279,476
Ensembl chr  X:97,253,586...97,279,476 		JBrowse link
G Cstf2t cleavage stimulation factor subunit 2, tau variant part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:228,952,617...228,956,183
Ensembl chr 1:228,952,504...228,955,873 		JBrowse link
G Fip1l1 factor interacting with PAPOLA and CPSF1 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000118
GO_REF:0000033
(PMID:19224921)		 Ensembl
TreeGrafter
GO_Central
RGD		 PMID:19224921 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:33,615,210...33,675,742
Ensembl chr14:33,617,720...33,675,708 		JBrowse link
G Nudt21 nudix hydrolase 21 part_of ISO (PMID:23187700) RGD PMID:23187700 NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha part_of
located_in		 IEA
ISO		 GO_REF:0000107
(PMID:18305108)		 Ensembl
RGD		 PMID:18305108 GO_REF:0000107 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598 		JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429 		JBrowse link
G Sympk symplekin scaffold protein part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684 		JBrowse link
G Tut1 terminal uridylyl transferase 1, U6 snRNA-specific part_of
located_in		 ISS
ISO		 GO_REF:0000024
(PMID:21102410)
(PMID:18305108)		 UniProt
RGD		 PMID:18305108 PMID:21102410 GO_REF:0000024 NCBI chr 1:205,848,691...205,859,767
Ensembl chr 1:205,848,772...205,859,764 		JBrowse link
G Wdr33 WD repeat domain 33 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597 		JBrowse link
G Zc3h3 zinc finger CCCH type containing 3 part_of ISO (PMID:16115198) RGD PMID:16115198 NCBI chr 7:107,440,694...107,525,451
Ensembl chr 7:107,440,694...107,525,451 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      nuclear protein-containing complex 1383
        mRNA cleavage factor complex 25
          mRNA cleavage and polyadenylation specificity factor complex 20
Path 2
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      organelle 14344
        membrane-bounded organelle 12919
          intracellular membrane-bounded organelle 12331
            nucleus 7726
              nuclear protein-containing complex 1383
                mRNA cleavage factor complex 25
                  mRNA cleavage and polyadenylation specificity factor complex 20
paths to the root