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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal CD8-positive, alpha beta T cell morphology
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Accession:MP:0005010 term browser browse the term
Definition:any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: CD8+ T cell abnormalities;   abnormal CD8+ T cell morphology;   abnormal CD8-positive T cell morphology
 broad_synonym: abnormal single positive T cell morphology


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decreased CD8-positive, alpha-beta T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403
Term paths to the root
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  mammalian phenotype 5419
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal effector T cell morphology 23
                    abnormal CD8-positive, alpha beta T cell morphology 11
                      abnormal CD8 positive, alpha-beta intraepithelial T cell morphology 0
                      abnormal CD8-positive, alpha-beta T cell differentiation 0
                      abnormal CD8-positive, alpha-beta T cell number + 9
                      abnormal CD8-positive, alpha-beta cytotoxic T cell morphology 0
                      abnormal CD8-positive, alpha-beta memory T cell morphology + 0
                      abnormal CD8-positive, alpha-beta regulatory T cell morphology 0
                      abnormal Tc17 cell morphology + 0
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