The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner
Comment:
Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
Synonyms:
exact_synonym:
abnormal CD8-positive, alpha-beta cytotoxic T lymphocyte morphology
broad_synonym:
abnormal CTL morphology; abnormal cytotoxic T cell morphology; abnormal cytotoxic T lymphocyte morphology; cytotoxic T cell abnormalities