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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
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Accession:MP:0002436 term browser browse the term
Definition:any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner
Comment:Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
Synonyms:exact_synonym: abnormal CD8-positive, alpha-beta cytotoxic T lymphocyte morphology
 broad_synonym: abnormal CTL morphology;   abnormal cytotoxic T cell morphology;   abnormal cytotoxic T lymphocyte morphology;   cytotoxic T cell abnormalities
 xref: CL:0000794



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  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal T cell morphology 67
                  abnormal effector T cell morphology 21
                    abnormal CD8-positive, alpha beta T cell morphology 11
                      abnormal CD8-positive, alpha-beta cytotoxic T cell morphology 0
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