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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:hemophagocytosis
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Accession:MP:0031070 term browser browse the term
Definition:a pathologic process of engulfment of erythrocytes, leukocytes, platelets, and their precursors by histiocytes, either in the bone marrow or in other parts of the reticuloendothelial system; it is a nonspecific phenotypic feature observed in several conditions including hemolytic anemia, malignant disease, infections, and hemophagocytic syndrome (also known as hemophagocytic lymphohistiocytosis, a rare hyperinflammatory syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune process)
Synonyms:exact_synonym: haemophagocytosis
 xref: HP:0012156


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Term Annotations click to browse term
  mammalian phenotype 5421
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal innate immunity 24
          abnormal macrophage physiology 5
            hemophagocytosis 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5421
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal cell-mediated immunity 56
          abnormal leukocyte physiology 56
            abnormal macrophage physiology 5
              hemophagocytosis 0
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