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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal macrophage physiology
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Accession:MP:0002451 term browser browse the term
Definition:any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
Synonyms:exact_synonym: macrophage dysfunction



show annotations for term's descendants           Sort by:
abnormal microglial cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
increased microglial cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5408
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal innate immunity 24
          abnormal macrophage physiology 5
            abnormal macrophage activation involved in immune response 0
            abnormal macrophage antigen presentation + 0
            abnormal macrophage apoptosis + 0
            abnormal macrophage chemotaxis + 0
            abnormal macrophage cytokine production + 2
            abnormal macrophage nitric oxide production + 0
            abnormal macrophage proliferation + 0
            abnormal microglial cell physiology + 3
            abnormal osteoclast physiology 0
            hemophagocytosis 0
            impaired macrophage phagocytosis 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5408
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal cell-mediated immunity 56
          abnormal leukocyte physiology 56
            abnormal macrophage physiology 5
              abnormal macrophage activation involved in immune response 0
              abnormal macrophage antigen presentation + 0
              abnormal macrophage apoptosis + 0
              abnormal macrophage chemotaxis + 0
              abnormal macrophage cytokine production + 2
              abnormal macrophage nitric oxide production + 0
              abnormal macrophage proliferation + 0
              abnormal microglial cell physiology + 3
              abnormal osteoclast physiology 0
              hemophagocytosis 0
              impaired macrophage phagocytosis 0
paths to the root