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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased tumor necrosis factor secretion
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Accession:MP:0008561 term browser browse the term
Definition:reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms:exact_synonym: decreased TNF secretion;   decreased TNFA secretion;   decreased cachectin secretion;   decreased tumor necrosis factor alpha secretion;   decreased tumour necrosis factor alpha secretion;   decreased tumour necrosis factor secretion;   reduced TNF secretion;   reduced TNFA secretion;   reduced cachectin secretion;   reduced tumor necrosis factor alpha secretion;   reduced tumour necrosis factor alpha secretion


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decreased tumor necrosis factor secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr4 toll-like receptor 4 IMP RGD PMID:24199847 RGD:12910488 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr4em1Geh toll-like receptor 4; mutation 1, Gregg E. Homanics IMP RGD PMID:24199847 RGD:12910488
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  mammalian phenotype 5403
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine secretion 24
            abnormal tumor necrosis factor secretion 5
              decreased tumor necrosis factor secretion 4
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