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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

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Accession:HP:0100758 term browser browse the term
Definition:A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
Comment:This may occur after an injury or infection, or in people suffering from any chronic health problem affecting blood circulation. The prime cause of gangrene is reduced blood supply to the affected tissues, which results in cell death. Diabetes and long-term smoking increase the risk of suffering from gangrene. There are different types of gangrene with different symptoms, such as dry gangrene, wet gangrene, gas gangrene, internal gangrene and necrotising fasciitis. Treatment options include debridement (or, in severe cases, amputation) of the affected body parts, antibiotics, vascular surgery, maggot therapy or hyperbaric oxygen therapy.
Synonyms:exact_synonym: Death of body tissue due to lack of blood flow or infection
 xref: MESH:D005734;   SNOMEDCT_US:36024000;   SNOMEDCT_US:372070002;   UMLS:C0017086

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  Human phenotype 0
    Phenotypic abnormality 0
      Constitutional symptom 0
        Gangrene 0
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