Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Constitutional symptom
go back to main search page
Accession:HP:0025142 term browser browse the term
Definition:A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.
Comment:Note that we use the preferred term label constitutional symptom because this reflects common usage, but we do not restrict the term or its descendents to the narrow meaning of symptom, i.e., a complaint related by a patient to a physician. There is no generally accepted classification of what defines a constitutional symptom, but examples include weight loss, fatigue, general weakness, night sweats, shaking, chills, fever, and vomiting.

show annotations for term's descendants           Sort by:

Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Constitutional symptom 0
        Asthenia 0
        Body ache 0
        Body odor + 0
        Chest tightness 0
        Chills + 0
        Coldness 0
        Diminished health-related quality of life + 0
        Exercise intolerance + 0
        Fatigue + 0
        Frailty 0
        Gangrene 0
        Halitosis + 0
        Hot flashes 0
        Impairment of activities of daily living + 0
        Malaise 0
        Night sweats 0
        Occupational disability 0
        Pain + 0
        Recurrent singultus 0
        Shivering + 0
        Sneeze + 0
        Sudden death + 0
paths to the root