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ONTOLOGY REPORT - ANNOTATIONS

Term:pH-gated monoatomic ion channel activity
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Accession:GO:0160128 term browser browse the term
Definition:Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).
Comment:While the term suggest this activity may be proton-gated, the mechanism of pH-gating for transporters is by protonation of specific residues in the protein, and not by H+ binding.
Synonyms:related_synonym: acid-sensing ion channel activity;   proton-gated ion channel activity
 xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol"


show annotations for term's descendants           Sort by:
pH-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC1 acid sensing ion channel subunit 1 enables
NOT|enables		 IEA
ISO		 (PMID:21036899) Ensembl
UniProt
TreeGrafter		 PMID:21036899 GO_REF:0000107 GO_REF:0000118 NCBI chr12:38,672,253...38,698,247 JBrowse link
G ASIC3 acid sensing ion channel subunit 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:142,633,357...142,639,571
Ensembl chr 7:154,786,835...154,792,289 		JBrowse link
G PKD1L3 polycystin 1 like 3, transient receptor potential channel interacting enables IEA Ensembl GO_REF:0000107 NCBI chr16:53,002,427...53,081,964
Ensembl chr16:71,764,791...71,845,674 		JBrowse link
G PKD2L1 polycystin 2 like 1, transient receptor potential cation channel enables IEA Ensembl GO_REF:0000107 NCBI chr10:96,889,228...96,932,177
Ensembl chr10:100,370,083...100,412,366 		JBrowse link
G ZACN zinc activated ion channel enables IEA Ensembl GO_REF:0000107 NCBI chr17:70,028,902...70,033,013
Ensembl chr17:75,582,443...75,586,058 		JBrowse link
pH-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC3 acid sensing ion channel subunit 3 enables ISO PMID:11120882 UniProt PMID:11120882 RGD:596936209 NCBI chr 7:142,633,357...142,639,571
Ensembl chr 7:154,786,835...154,792,289 		JBrowse link
pH-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP6 aquaporin 6 enables ISO PMID:10647010 UniProt PMID:10647010 RGD:408345219 NCBI chr12:38,739,047...38,782,659
Ensembl chr12:39,672,067...39,676,636 		JBrowse link
G PACC1 proton activated chloride channel 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:187,928,923...187,980,274
Ensembl chr 1:192,790,932...192,843,577 		JBrowse link
pH-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC2 acid sensing ion channel subunit 2 enables ISO PMID:10842183
(PMID:9368048)
(PMID:10842183)		 UniProt PMID:9368048 PMID:10842183 RGD:596936210 NCBI chr17:22,628,322...23,774,249 JBrowse link
G ASIC3 acid sensing ion channel subunit 3 enables ISO PMID:10842183
PMID:11120882
(PMID:10842183), (PMID:9744806), (PMID:9886053)		 UniProt PMID:9744806 PMID:9886053 PMID:10842183 PMID:11120882 RGD:596936209 RGD:596936210 NCBI chr 7:142,633,357...142,639,571
Ensembl chr 7:154,786,835...154,792,289 		JBrowse link
G ASIC4 acid sensing ion channel subunit family member 4 NOT|enables ISO PMID:10852210
PMID:10923674		 UniProt PMID:10852210 PMID:10923674 RGD:596936205 RGD:632227 NCBI chr2B:106,770,714...106,796,044
Ensembl chr2B:225,361,477...225,386,081 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19294
    transporter activity 1163
      transmembrane transporter activity 1062
        monoatomic ion transmembrane transporter activity 718
          monoatomic ion channel activity 440
            ligand-gated monoatomic ion channel activity 186
              pH-gated monoatomic ion channel activity 9
                pH-gated calcium channel activity 1
                pH-gated chloride channel activity 2
                pH-gated sodium channel activity 3
Path 2
Term Annotations click to browse term
  molecular_function 19294
    transporter activity 1163
      transmembrane transporter activity 1062
        passive transmembrane transporter activity 495
          channel activity 495
            gated channel activity 324
              ligand-gated channel activity 191
                ligand-gated monoatomic ion channel activity 186
                  pH-gated monoatomic ion channel activity 9
                    pH-gated calcium channel activity 1
                    pH-gated chloride channel activity 2
                    pH-gated sodium channel activity 3
paths to the root